Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Molly M, He"'
Autor:
Graham K. Farrington, Jessica E. Friedman, Joshua C. Yoburn, Alexey Lugovskoy, William Michael Flanagan, Stephan K. Miller, Brian C. Cunningham, Amy D. Fung, Adrian Whitty, Molly M. He, Jun Wang, Annemarie Stroustrup Smith, Mark T. Cancilla, John Eldredge, Leslie A. Cruz, Johan D. Oslob, Teresa G. Cachero, Andrew C. Braisted, Eric S. Day, Ingrid C. Choong
Publikováno v:
Science. 310:1022-1025
We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-α activity in biochemical and cell-based assays with median inhib
Autor:
Meggin Taylor, Robert Lowell Simmons, Amy D. Fung, Daniel A. Erlanson, Mark T. Cancilla, Nina Viswanathan, Molly M. He, Kathy Cao
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(14)
We demonstrate a fragment-based lead discovery method that combines site-directed ligand discovery with dynamic combinatorial chemistry. Our technique targets dynamic combinatorial screening to a specified region of a protein by using reversible disu
Autor:
Molly M, He, Annemarie Stroustrup, Smith, Johan D, Oslob, William M, Flanagan, Andrew C, Braisted, Adrian, Whitty, Mark T, Cancilla, Jun, Wang, Alexey A, Lugovskoy, Josh C, Yoburn, Amy D, Fung, Graham, Farrington, John K, Eldredge, Eric S, Day, Leslie A, Cruz, Teresa G, Cachero, Stephan K, Miller, Jessica E, Friedman, Ingrid C, Choong, Brian C, Cunningham
Publikováno v:
Science (New York, N.Y.). 310(5750)
We have identified a small-molecule inhibitor of tumor necrosis factor alpha (TNF-alpha) that promotes subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-alpha activity in biochemical and cell-based assays with med
Autor:
Molly M. He, Jenny Kung, Stig Hansen, Daniel A. Erlanson, Robert S. McDowell, Andrew B. Waight, Mike Randal, Robert Lowell Simmons
Publikováno v:
Journal of the American Chemical Society. 125:5602-5603
Protein tyrosine phosphatases play important roles in many signaling cascades involved in human disease. The identification of druglike inhibitors for these targets is a major challenge, and the discovery of suitable phosphotyrosine (pY) mimetics rem
Autor:
Arslan S; Element Biosciences, San Diego, CA, USA., Garcia FJ; Element Biosciences, San Diego, CA, USA., Guo M; Element Biosciences, San Diego, CA, USA., Kellinger MW; Element Biosciences, San Diego, CA, USA., Kruglyak S; Element Biosciences, San Diego, CA, USA., LeVieux JA; Element Biosciences, San Diego, CA, USA., Mah AH; Element Biosciences, San Diego, CA, USA., Wang H; Element Biosciences, San Diego, CA, USA., Zhao J; Element Biosciences, San Diego, CA, USA., Zhou C; Element Biosciences, San Diego, CA, USA., Altomare A; Element Biosciences, San Diego, CA, USA., Bailey J; Element Biosciences, San Diego, CA, USA., Byrne MB; Element Biosciences, San Diego, CA, USA., Chang C; Element Biosciences, San Diego, CA, USA., Chen SX; Element Biosciences, San Diego, CA, USA., Cho B; Element Biosciences, San Diego, CA, USA., Dennler CN; Element Biosciences, San Diego, CA, USA., Dien VT; Element Biosciences, San Diego, CA, USA., Fuller D; Element Biosciences, San Diego, CA, USA., Kelley R; Element Biosciences, San Diego, CA, USA., Khandan O; Element Biosciences, San Diego, CA, USA., Klein MG; Element Biosciences, San Diego, CA, USA., Kim M; Element Biosciences, San Diego, CA, USA., Lajoie BR; Element Biosciences, San Diego, CA, USA., Lin B; Element Biosciences, San Diego, CA, USA., Liu Y; Element Biosciences, San Diego, CA, USA., Lopez T; Element Biosciences, San Diego, CA, USA., Mains PT; Element Biosciences, San Diego, CA, USA., Price AD; Element Biosciences, San Diego, CA, USA., Robertson SR; Element Biosciences, San Diego, CA, USA., Taylor-Weiner H; Element Biosciences, San Diego, CA, USA., Tippana R; Element Biosciences, San Diego, CA, USA., Tomaney AB; Element Biosciences, San Diego, CA, USA., Zhang S; Element Biosciences, San Diego, CA, USA., Abtahi M; Element Biosciences, San Diego, CA, USA., Ambroso MR; Element Biosciences, San Diego, CA, USA., Bajari R; Element Biosciences, San Diego, CA, USA., Bellizzi AM; Element Biosciences, San Diego, CA, USA., Benitez CB; Element Biosciences, San Diego, CA, USA., Berard DR; Element Biosciences, San Diego, CA, USA., Berti L; Element Biosciences, San Diego, CA, USA., Blease KN; Element Biosciences, San Diego, CA, USA., Blum AP; Element Biosciences, San Diego, CA, USA., Boddicker AM; Element Biosciences, San Diego, CA, USA., Bondar L; Element Biosciences, San Diego, CA, USA., Brown C; Element Biosciences, San Diego, CA, USA., Bui CA; Element Biosciences, San Diego, CA, USA., Calleja-Aguirre J; Element Biosciences, San Diego, CA, USA., Cappa K; Element Biosciences, San Diego, CA, USA., Chan J; Element Biosciences, San Diego, CA, USA., Chang VW; Element Biosciences, San Diego, CA, USA., Charov K; Element Biosciences, San Diego, CA, USA., Chen X; Element Biosciences, San Diego, CA, USA., Constandse RM; Element Biosciences, San Diego, CA, USA., Damron W; Element Biosciences, San Diego, CA, USA., Dawood M; Element Biosciences, San Diego, CA, USA., DeBuono N; Element Biosciences, San Diego, CA, USA., Dimalanta JD; Element Biosciences, San Diego, CA, USA., Edoli L; Element Biosciences, San Diego, CA, USA., Elango K; Element Biosciences, San Diego, CA, USA., Faustino N; Element Biosciences, San Diego, CA, USA., Feng C; Element Biosciences, San Diego, CA, USA., Ferrari M; Element Biosciences, San Diego, CA, USA., Frankie K; Element Biosciences, San Diego, CA, USA., Fries A; Element Biosciences, San Diego, CA, USA., Galloway A; Element Biosciences, San Diego, CA, USA., Gavrila V; Element Biosciences, San Diego, CA, USA., Gemmen GJ; Element Biosciences, San Diego, CA, USA., Ghadiali J; Element Biosciences, San Diego, CA, USA., Ghorbani A; Element Biosciences, San Diego, CA, USA., Goddard LA; Element Biosciences, San Diego, CA, USA., Guetter AR; Element Biosciences, San Diego, CA, USA., Hendricks GL; Element Biosciences, San Diego, CA, USA., Hentschel J; Element Biosciences, San Diego, CA, USA., Honigfort DJ; Element Biosciences, San Diego, CA, USA., Hsieh YT; Element Biosciences, San Diego, CA, USA., Hwang Fu YH; Element Biosciences, San Diego, CA, USA., Im SK; Element Biosciences, San Diego, CA, USA., Jin C; Element Biosciences, San Diego, CA, USA., Kabu S; Element Biosciences, San Diego, CA, USA., Kincade DE; Element Biosciences, San Diego, CA, USA., Levy S; Element Biosciences, San Diego, CA, USA., Li Y; Element Biosciences, San Diego, CA, USA., Liang VK; Element Biosciences, San Diego, CA, USA., Light WH; Element Biosciences, San Diego, CA, USA., Lipsher JB; Element Biosciences, San Diego, CA, USA., Liu TL; Element Biosciences, San Diego, CA, USA., Long G; Element Biosciences, San Diego, CA, USA., Ma R; Element Biosciences, San Diego, CA, USA., Mailloux JM; Element Biosciences, San Diego, CA, USA., Mandla KA; Element Biosciences, San Diego, CA, USA., Martinez AR; Element Biosciences, San Diego, CA, USA., Mass M; Element Biosciences, San Diego, CA, USA., McKean DT; Element Biosciences, San Diego, CA, USA., Meron M; Element Biosciences, San Diego, CA, USA., Miller EA; Element Biosciences, San Diego, CA, USA., Moh CS; Element Biosciences, San Diego, CA, USA., Moore RK; Element Biosciences, San Diego, CA, USA., Moreno J; Element Biosciences, San Diego, CA, USA., Neysmith JM; Element Biosciences, San Diego, CA, USA., Niman CS; Element Biosciences, San Diego, CA, USA., Nunez JM; Element Biosciences, San Diego, CA, USA., Ojeda MT; Element Biosciences, San Diego, CA, USA., Ortiz SE; Element Biosciences, San Diego, CA, USA., Owens J; Element Biosciences, San Diego, CA, USA., Piland G; Element Biosciences, San Diego, CA, USA., Proctor DJ; Element Biosciences, San Diego, CA, USA., Purba JB; Element Biosciences, San Diego, CA, USA., Ray M; Element Biosciences, San Diego, CA, USA., Rong D; Element Biosciences, San Diego, CA, USA., Saade VM; Element Biosciences, San Diego, CA, USA., Saha S; Element Biosciences, San Diego, CA, USA., Tomas GS; Element Biosciences, San Diego, CA, USA., Scheidler N; Element Biosciences, San Diego, CA, USA., Sirajudeen LH; Element Biosciences, San Diego, CA, USA., Snow S; Element Biosciences, San Diego, CA, USA., Stengel G; Element Biosciences, San Diego, CA, USA., Stinson R; Element Biosciences, San Diego, CA, USA., Stone MJ; Element Biosciences, San Diego, CA, USA., Sundseth KJ; Element Biosciences, San Diego, CA, USA., Thai E; Element Biosciences, San Diego, CA, USA., Thompson CJ; Element Biosciences, San Diego, CA, USA., Tjioe M; Element Biosciences, San Diego, CA, USA., Trejo CL; Element Biosciences, San Diego, CA, USA., Trieger G; Element Biosciences, San Diego, CA, USA., Truong DN; Element Biosciences, San Diego, CA, USA., Tse B; Element Biosciences, San Diego, CA, USA., Voiles B; Element Biosciences, San Diego, CA, USA., Vuong H; Element Biosciences, San Diego, CA, USA., Wong JC; Element Biosciences, San Diego, CA, USA., Wu CT; Element Biosciences, San Diego, CA, USA., Yu H; Element Biosciences, San Diego, CA, USA., Yu Y; Element Biosciences, San Diego, CA, USA., Yu M; Element Biosciences, San Diego, CA, USA., Zhang X; Element Biosciences, San Diego, CA, USA., Zhao D; Element Biosciences, San Diego, CA, USA., Zheng G; Element Biosciences, San Diego, CA, USA., He M; Element Biosciences, San Diego, CA, USA., Previte M; Element Biosciences, San Diego, CA, USA. mprevite@elembio.com.
Publikováno v:
Nature biotechnology [Nat Biotechnol] 2024 Jan; Vol. 42 (1), pp. 132-138. Date of Electronic Publication: 2023 May 25.
Autor:
Chen H; Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Shao J; Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Zhang H; Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Jiang M; Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Huang L; Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Zhang Z; Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Yang D; Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., He M; Illumina, Inc., San Diego, CA, United States., Ronaghi M; Illumina, Inc., San Diego, CA, United States., Luo X; Illumina, Inc., San Diego, CA, United States., Sun B; Illumina, Inc., San Diego, CA, United States., Wu W; Guangxi Botanical Garden of Medicinal Plants, Nanning, China., Liu C; Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Publikováno v:
Frontiers in plant science [Front Plant Sci] 2018 Mar 14; Vol. 9, pp. 324. Date of Electronic Publication: 2018 Mar 14 (Print Publication: 2018).
Autor:
Renhowe PA; Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, California 94608-2419, USA. paul.renhowe@novartis.com, Pecchi S, Shafer CM, Machajewski TD, Jazan EM, Taylor C, Antonios-McCrea W, McBride CM, Frazier K, Wiesmann M, Lapointe GR, Feucht PH, Warne RL, Heise CC, Menezes D, Aardalen K, Ye H, He M, Le V, Vora J, Jansen JM, Wernette-Hammond ME, Harris AL
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2009 Jan 22; Vol. 52 (2), pp. 278-92.