Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Molly Kulesz-Martin"'
Autor:
Myles Vigoda, Chase Mathieson, Nathaniel Evans, Carolyn Hale, Jennifer Jennings, Olivia Lucero, Sophia Jeng, Daniel Bottomly, Daniel Clayburgh, Peter Andersen, Ryan Li, Daniel Petrisor, Jeffrey W. Tyner, Shannon McWeeney, Molly Kulesz-Martin
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 309-317 (2022)
In this study, we report a differential response of mitogen-activated protein kinase–kinase (MEK) inhibitor trametinib in 20 head and neck squamous cell carcinoma (HNSCC) patients’ tumor-derived cell cultures. Relatively sensitive and resistant c
Externí odkaz:
https://doaj.org/article/b341787595d24a049de4dd01f9d67b72
Autor:
Steven R. Chamberlin, Aurora Blucher, Guanming Wu, Lynne Shinto, Gabrielle Choonoo, Molly Kulesz-Martin, Shannon McWeeney
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
A body of research demonstrates examples of in vitro and in vivo synergy between natural products and anti-neoplastic drugs for some cancers. However, the underlying biological mechanisms are still elusive. To better understand biological entities ta
Externí odkaz:
https://doaj.org/article/8b2df493469142229243797fc206298f
Autor:
Gabrielle Choonoo, Aurora S Blucher, Samuel Higgins, Mitzi Boardman, Sophia Jeng, Christina Zheng, James Jacobs, Ashley Anderson, Steven Chamberlin, Nathaniel Evans, Myles Vigoda, Benjamin Cordier, Jeffrey W Tyner, Molly Kulesz-Martin, Shannon K McWeeney, Ted Laderas
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223639 (2019)
Head and neck squamous cell carcinoma (HNSCC) remains a morbid disease with poor prognosis and treatment that typically leaves patients with permanent damage to critical functions such as eating and talking. Currently only three targeted therapies ar
Externí odkaz:
https://doaj.org/article/0f321b85b06c45daaa3441e50f7ae2ed
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37636 (2012)
Negative regulation of the NF-κB transcription factor is essential for tissue homeostasis in response to stress and inflammation. NF-κB activity is regulated by a variety of biochemical mechanisms including phosphorylation, acetylation, and ubiquit
Externí odkaz:
https://doaj.org/article/f10aa78cac7245edbe3bd3fe0d1c91f1
Autor:
Eric L. Simpson, Zhiping Wang, Robert O. Messing, Yeon Jung Yoo, Rachel De La Torre, Christina Topham, Molly Kulesz-Martin, Yuangang Liu, Jon M. Hanifin
Publikováno v:
Journal of Investigative Dermatology. 141:1297-1307.e3
Atopic dermatitis (AD) is a T helper (Th)2-biased disease with elevated expression of Th2 cytokines that responds to Th2 signaling blockade. TRIM32 is an E3 ubiquitin ligase with innate antiviral activity. In our previous studies, we showed that Trim
Autor:
Fulvio Reggiori, Monica Dentice, Marcella Neri, Manuela Antonioli, M. Di Rienzo, Idil Orhon, Fabiola Ciccosanti, Alessandra Ferlini, Giuseppe Merla, F. Germani, Mauro Piacentini, Barbara Mandriani, H. Ding, Giulia Refolo, Muriel Mari, Maria Teresa Pellico, Marco Corazzari, Molly Kulesz-Martin, Carmela Fusco, Gian Maria Fimia, Yuangang Liu, Alessandra Romagnoli, R. De La Torre
Publikováno v:
Science Advances, 5(5):8857. AMER ASSOC ADVANCEMENT SCIENCE
Di Rienzo, M, Antonioli, M, Fusco, C, Liu, Y, Mari, M, Orhon, I, Refolo, G, Germani, F, Corazzari, M, Romagnoli, A, Ciccosanti, F, Mandriani, B, Pellico, M T, De La Torre, R, Ding, H, Dentice, M, Neri, M, Ferlini, A, Reggiori, F, Kulesz-Martin, M, Piacentini, M, Merla, G & Fimia, G M 2019, ' Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains ', Science Advances, vol. 5, no. 5, pp. eaau8857 . https://doi.org/10.1126/sciadv.aau8857
Science Advances
Di Rienzo, M, Antonioli, M, Fusco, C, Liu, Y, Mari, M, Orhon, I, Refolo, G, Germani, F, Corazzari, M, Romagnoli, A, Ciccosanti, F, Mandriani, B, Pellico, M T, De La Torre, R, Ding, H, Dentice, M, Neri, M, Ferlini, A, Reggiori, F, Kulesz-Martin, M, Piacentini, M, Merla, G & Fimia, G M 2019, ' Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains ', Science Advances, vol. 5, no. 5, pp. eaau8857 . https://doi.org/10.1126/sciadv.aau8857
Science Advances
Muscular dystrophy-associated mutations of TRIM32 impair ULK1-dependent autophagy response during muscle atrophy.
Optimal autophagic activity is crucial to maintain muscle integrity, with either reduced or excessive levels leading to specific my
Optimal autophagic activity is crucial to maintain muscle integrity, with either reduced or excessive levels leading to specific my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc5e5ef1f7060187c8321286a480b01
https://research.rug.nl/en/publications/4b803b6d-cd0a-4b3a-afe8-faf8661628fd
https://research.rug.nl/en/publications/4b803b6d-cd0a-4b3a-afe8-faf8661628fd
Autor:
Prashiela Manga, Amanda W. Lund, Sheri L. Holmen, Kenneth H. Kraemer, Thomas J. Hornyak, I. Caroline Le Poole, Boris C. Bastian, Cynthia D. Cooper, Clara E. Stemwedel, James E. Cleaver, John A. D'Orazio, Vijayasaradhi Setaluri, Sancy A. Leachman, Arup K. Indra, Greg Barsh, William J. Pavan, Molly Kulesz-Martin, Mayumi Fujita, Douglas E. Brash, Roger S. Lo
Publikováno v:
J Invest Dermatol
Autor:
Olivia M. Lucero, Christina Zheng, Ashley N. Anderson, Carolyn A. Hale, Xiaoming Ouyang, Shannon K. McWeeney, Justin J. Leitenberger, Anna Bar, Jeffrey W. Tyner, Myles Vigoda, Yeon Jung Yoo, James Jacobs, Molly Kulesz-Martin, Peter E. Andersen, Aurora Blucher, Danielle McClanahan, Daniel Clayburgh, Sophia Jeng
Publikováno v:
Cold Spring Harbor Molecular Case Studies
Although cutaneous squamous cell carcinoma (cSCC) is treatable in the majority of cases, deadly invasive and metastatic cases do occur. To date there are neither reliable predictive biomarkers of disease progression nor FDA-approved targeted therapie
Autor:
Molly Kulesz-Martin, Zhiping Wang, Jon M. Hanifin, Robert O. Messing, Christina Topham, R. De La Torre, Eric L. Simpson, A. Yoo, Yuangang Liu
Publikováno v:
Journal of Investigative Dermatology. 140:S4
Autor:
A. Barling, Sophia Jeng, Christina Zheng, Xiaoming Ouyang, Aletha Lesch, Shannon K. McWeeney, Toni M. West, Sara A. Courtneidge, Molly Kulesz-Martin, Gabrielle Choonoo, Jeffrey W. Tyner, Daniel R. Clayburgh
Publikováno v:
Cancer Biology & Therapy
Head and neck squamous cell carcinoma (HNSCC) currently only has one FDA-approved cancer intrinsic targeted therapy, the epidermal growth factor receptor (EGFR) inhibitor cetuximab, to which only approximately 10% of tumors are sensitive. In order to