Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirs

Autor: Erica C. Pehrsson, Kevin J. Forsberg, Molly K. Gibson, Sara eAhmadi, Gautam eDantas

Publikováno v: Frontiers in Microbiology, Vol 4 (2013)

Rates of infection with antibiotic-resistant bacteria have increased precipitously over the past several decades, with far-reaching healthcare and societal costs. Recent evidence has established a link between antibiotic resistance genes in human pat

Externí odkaz: https://doaj.org/article/1090531baaee430693943b1b01702801

Publisher Correction: Shared strategies for β-lactam catabolism in the soil microbiome

Autor: C. Nicole Rosenzweig, Gautam Dantas, Molly K. Gibson, Morten Otto Alexander Sommer, Kevin J. Forsberg, Lauren A. Johnsky, Bin Wang, Tara A. Gianoulis, Evan W. Skowronski, Aaron Spivak, Terence S. Crofts, Henry S. Gibbons, S. M. Broomall

Publikováno v: Nature chemical biology

The soil microbiome can produce, resist, or degrade antibiotics and even catabolize them. While resistance genes are widely distributed in the soil, there is a dearth of knowledge concerning antibiotic catabolism. Here we describe a pathway for penic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8122581ada13b53bcee08e24448b21d
https://pubmed.ncbi.nlm.nih.gov/29713061

Characterization of Wild and Captive Baboon Gut Microbiota and Their Antibiotic Resistomes

Autor: Jeffrey Rogers, Manish Boolchandani, Erica C. Pehrsson, Jane E. Phillips-Conroy, Gautam Dantas, Pablo Tsukayama, Kenneth L Chiou, Sanket Patel, Molly K. Gibson, Clifford J. Jolly

Publikováno v: mSystems
mSystems, Vol 3, Iss 3 (2018)
mSystems, Vol 3, Iss 3, p e00016-18 (2018)

Antibiotic exposure results in acute and persistent shifts in the composition and function of microbial communities associated with vertebrate hosts. However, little is known about the state of these communities in the era before the widespread intro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d4ca76c05ee5fe7f88e59e26b6c218
http://europepmc.org/articles/PMC6020475

Draft Genome Sequences of Three β-Lactam-Catabolizing Soil Proteobacteria

Autor: Gautam Dantas, Kevin J. Forsberg, Henry S. Gibbons, Molly K. Gibson, S. M. Broomall, Terence S. Crofts, Evan W. Skowronski, Bin Wang, C. Nicole Rosenzweig, Aaron Spivak, Lauren A. Johnsky, Tara A. Gianoulis, Morten Otto Alexander Sommer

Publikováno v: Crofts, T S, Wang, B, Spivak, A, Gianoulis, T A, Forsberg, K J, Gibson, M K, Johnsky, L A, Broomall, S M, Rosenzweig, C N, Skowronski, E W, Gibbons, H S, Sommer, M O A & Dantas, G 2017, ' Draft Genome Sequences of Three β-Lactam-Catabolizing Soil Proteobacteria ', Genome Announcements, vol. 5, no. 32, e00653-17 . https://doi.org/10.1128/genomeA.00653-17
Genome Announcements

Most antibiotics are derived from the soil, but their catabolism there, which is necessary to close the antibiotic carbon cycle, remains uncharacterized. We report the first draft genome sequences of soil Proteobacteria identified for subsisting sole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f540a52b50d462cb19e7608f4fd2f4f
https://doi.org/10.1128/genomea.00653-17

The Yin and Yang of Bacterial Resilience in the Human Gut Microbiota

Autor: Molly K. Gibson, Gautam Dantas, Mitchell W. Pesesky

Publikováno v: Journal of Molecular Biology. 426:3866-3876

The human gut is home to trillions of microbes that form a symbiotic relationship with the human host. During health, the intestinal microbiota provides many benefits to the host and is generally resistant to colonization by new species; however, dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d1b21ad6edeac48f6bdb5506e7f5f2
https://doi.org/10.1016/j.jmb.2014.05.029