Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Molly K. Altman"'
Autor:
Nicholas C. Vierra, Matthew T. Dickerson, Kelli L. Jordan, Prasanna K. Dadi, Ketaki A. Kadare, Molly K. Altman, Sarah C. Milian, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 84-97 (2018)
Objective: Single-cell RNA sequencing studies have revealed that the type-2 diabetes associated two-pore domain K+ (K2P) channel TALK-1 is abundantly expressed in somatostatin-secreting δ-cells. However, a physiological role for TALK-1 in δ-cells r
Externí odkaz:
https://doaj.org/article/1d9f371e00d5410b87f2af7f170d89cf
Autor:
Molly K. Altman, Duy T. Nguyen, Santosh B. Patel, Jada M. Fambrough, Aaron M. Beedle, William J. Hardman, Mandi M. Murph
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
The regulator of G-protein signaling 5 (RGS5) belongs to a family of GTPase activators that terminate signaling cascades initiated by extracellular mediators and G-protein-coupled receptors. RGS5 has an interesting dual biological role. One functiona
Externí odkaz:
https://doaj.org/article/d24ae6c5e231406faad28ac26d41a8d8
Autor:
Zixiu, Xiang, Xiaohui, Lv, Xin, Lin, Daniel E, O'Brien, Molly K, Altman, Craig W, Lindsley, Jonathan A, Javitch, Colleen M, Niswender, P Jeffrey, Conn
Publikováno v:
Sci Signal
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that regulate various aspects of central nervous system processing in normal physiology and in disease. They are thought to function as disulfide-linked homodimers, but studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ac13b2be884796b1312bc0e9c0555dda
https://pubmed.ncbi.nlm.nih.gov/33824180
https://pubmed.ncbi.nlm.nih.gov/33824180
Autor:
Colleen M. Niswender, Daniel E. O’Brien, Xiaohui Lv, Molly K. Altman, Zixiu Xiang, Craig W. Lindsley, Xin Lin, Jonathan A. Javitch, P. Jeffrey Conn
Publikováno v:
Science Signaling. 14
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that regulate various aspects of central nervous system processing in normal physiology and in disease. They are thought to function as disulfide-linked homodimers, but studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0654c27203e610965cf23a871d5699d9
https://doi.org/10.1126/scisignal.abd2319
https://doi.org/10.1126/scisignal.abd2319
Autor:
Thomas J. Galletta, Prasanna K. Dadi, Ariel S. Thorson, Guoqiang Gu, Gautami Amarnath, David A. Jacobson, Charles M. Schaub, Matthew T. Dickerson, Molly K. Altman, Sarah M. Graff
The melastatin subfamily of the transient receptor potential channels (TRPM) are regulators of pancreatic β-cell function. TRPM7 is the most abundant islet TRPM channel; however, the role of TRPM7 in β-cell function has not been determined. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ca3ee2eaac69c7dd64ee81e19168040
https://doi.org/10.1101/2020.07.15.204974
https://doi.org/10.1101/2020.07.15.204974
Autor:
Matthew T. Dickerson, Ariel S. Thorson, Molly K. Altman, Gautami Amarnath, Nicholas C. Vierra, David A. Jacobson, Kelli L. Jordan, Kenneth R. Verlage, Prasanna K. Dadi
Pancreatic α-cells exhibit oscillations in cytosolic Ca2+(Ca2+c), which control pulsatile glucagon (GCG) secretion. However, the mechanisms that modulate α-cell Ca2+coscillations have not been elucidated. As β-cell Ca2+coscillations are regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d53efd085db7cb0d80cb200c5f0727
https://europepmc.org/articles/PMC6482666/
https://europepmc.org/articles/PMC6482666/
Autor:
Aaron M. Beedle, Ha T. Nguyen, Mihir B. Patel, Sterling K. Tran, Mandi M. Murph, Jada M. Fambrough, Pooya Hoseinzadeh, Molly K. Altman, Ali A. Alshamrani, Wei Jia
Publikováno v:
Cancer Letters. 369:175-183
The regulator of G protein signaling 10 (RGS10) protein is a GTPase activating protein that accelerates the hydrolysis of GTP and therefore canonically inactivates G proteins, ultimately terminating signaling. Rheb is a small GTPase protein that shut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d6319b0b468afd9d1c16ae56fdb957
https://doi.org/10.1016/j.canlet.2015.08.012
https://doi.org/10.1016/j.canlet.2015.08.012
Autor:
Matthew T. Dickerson, Molly K. Altman, Prasanna K. Dadi, Nicholas C. Vierra, David A. Jacobson
Publikováno v:
Diabetes. 67
Calcium influx into pancreatic α-cells through voltage-dependent calcium channels (VDCCs) is required for glucagon (GCG) secretion and the mechanisms that mediate this process become defective during the pathogenesis of diabetes. Potassium channels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcc4a6b2fc217fc10dbfa84b7958d64a
https://doi.org/10.2337/db18-2172-p
https://doi.org/10.2337/db18-2172-p
Autor:
Kelli L. Jordan, Sarah C. Milian, David A. Jacobson, Molly K. Altman, Avery M. Bogart, Prasanna K. Dadi, Matthew T. Dickerson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Cytokines present during low-grade inflammation contribute to β-cell dysfunction and diabetes. Cytokine signaling disrupts β-cell glucose-stimulated Ca2+ influx (GSCI) and endoplasmic reticulum (ER) Ca2+ ([Ca2+]ER) handling, leading to diminished g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0855bcc1398021a73ab630a1c3ba55
https://doi.org/10.1038/s41598-018-19600-x
https://doi.org/10.1038/s41598-018-19600-x