Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Molly Gasperini"'
Autor:
José L. McFaline-Figueroa, Sanjay Srivatsan, Andrew J. Hill, Molly Gasperini, Dana L. Jackson, Lauren Saunders, Silvia Domcke, Samuel G. Regalado, Paul Lazarchuck, Sarai Alvarez, Raymond J. Monnat, Jay Shendure, Cole Trapnell
Publikováno v:
bioRxiv
SummaryChemical genetic screens are a powerful tool for exploring how cancer cells’ response to drugs is shaped by their mutations, yet they lack a molecular view of the contribution of individual genes to the response to exposure. Here, we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81974f1a25cd3d58cf74d5b8e18a83bb
https://europepmc.org/articles/PMC10312454/
https://europepmc.org/articles/PMC10312454/
Autor:
Fauna Yarza, Duke Hong, Yi Zhang, James Boocock, Scott W. Simpkins, Nathan B. Lubock, Leonid Kruglyak, Bianca Judy Choe, Aaron R. Cooper, Molly Gasperini, Manish J. Butte, Isabella Lin, Valerie A. Arboleda, Laila Sathe, Nathan LaPierre, Jonathan Flint, Oliver F. Brandenberg, Evann E. Hilt, Robert Damoiseaux, Jimin Park, Sukantha Chandrasekaran, Lior Pachter, Eric T. Jones, Tre Quan Love, Sriram Kosuri, Mark Lucas, Dawn Marquette, Clifford Kravit, Gabriel Oland, Stephania Kay, Kyle M. Kovary, A. Sina Booeshaghi, Chongyuan Luo, Joshua S. Bloom, Longhua Guo, Erin M. Thompson, Yi Yin, Omai B. Garner, Myles Hochman, Eleazar Eskin, Chetan Munugala
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 2
article-version (status) pre
article-version (number) 2
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is due to the high rates of transmission by individuals who are asymptomatic at the time of transmission1,2. Frequent, widespread testing of the asymptomatic population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbd40c7106e112bb4624cbb4d11fee3
https://resolver.caltech.edu/CaltechAUTHORS:20201119-132151980
https://resolver.caltech.edu/CaltechAUTHORS:20201119-132151980
Autor:
Nathan LaPierre, Chongyuan Luo, Sukantha Chandrasekaran, Sriram Kosuri, Erin M. Thompson, Gabriel Oland, Mark Lucas, Chetan Munugala, Duke Hong, Manish J. Butte, Scott W. Simpkins, Jonathan Flint, Isabella Lin, Lior Pachter, Omai B. Garner, Stephania Kay, James Boocock, Molly Gasperini, Leonid Kruglyak, Bianca Judy Choe, Laila Sathe, Robert Damoiseaux, A. Sina Booeshaghi, Yi Yin, Longhua Guo, Kyle M. Kovary, Myles Hochman, Eleazar Eskin, Valerie A. Arboleda, Joshua S. Bloom, Nathan B. Lubock, Yi Zhang, Dawn Marquette, Fauna Yarza, Eric T. Jones, Clifford Kravit, Aaron R. Cooper, TreQuan Love, Oliver F. Brandenberg, Evann E. Hilt, Jimin Park
Publikováno v:
medRxiv, vol 1, iss 09-09
Author(s): Bloom, Joshua; Sathe, Laila; Munugala, Chetan; Jones, Eric; Gasperini, Molly; Lubock, Nathan; Yarza, Fauna; Thompson, Erin; Kovary, Kyle; Park, Jimin; Marquette, Dawn; Kay, Stephania; Lucas, Mark; Love, TreQuan; Booeshaghi, Sina; Brandenbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568a99d2399dab4da00c6569c91d4d46
Publikováno v:
Nat Rev Genet
The human gene catalogue is essentially complete, but we lack an equivalently vetted inventory of bona fide human enhancers. Hundreds of thousands of candidate enhancers have been nominated via biochemical annotations; however, only a handful of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c49ae216928e4037dfe6b7fdda06af9
https://pubmed.ncbi.nlm.nih.gov/31988385
https://pubmed.ncbi.nlm.nih.gov/31988385
Autor:
Kenneth A. Matreyek, Andrew J. Hill, Cole Trapnell, Jonathan S. Packer, Molly Gasperini, Lea M. Starita, Jay Shendure, José L. McFaline-Figueroa, Dana Jackson
Publikováno v:
Nature methods
Several groups recently coupled CRISPR perturbations and single-cell RNA-seq for pooled genetic screens. We demonstrate that vector designs of these studies are susceptible to ∼50% swapping of guide RNA-barcode associations because of lentiviral te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af21cb20fd0dd370378db3cab1f3487f
https://doi.org/10.1038/nmeth.4604
https://doi.org/10.1038/nmeth.4604
Publikováno v:
ACS Chemical Biology. 13:326-332
Enhancers control the spatiotemporal expression of genes and are essential for encoding differentiation and development. Since their discovery more than three decades ago, researchers have largely studied enhancers removed from their genomic context.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b92d3e31a1aa10344f2810f3354d07f
https://doi.org/10.1021/acschembio.7b00778
https://doi.org/10.1021/acschembio.7b00778
Autor:
José L. McFaline-Figueroa, Jay Shendure, Cole Trapnell, Andrew J. Hill, Benjamin L. Martin, Nadav Ahituv, Molly Gasperini
Expression quantitative trait locus (eQTL) and genome-wide association studies (GWAS) are powerful paradigms for mapping the determinants of gene expression and organismal phenotypes, respectively. However, eQTL mapping and GWAS are limited in scope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895341c2e1400cfad7e238fe1bededbf
Autor:
Riza M. Daza, Molly Gasperini, Jay Shendure, Anh Leith, Xingfan Huang, Joseph D. Janizek, Lea M. Starita, Zhang, Beth Martin, Gregory M. Findlay
Variants of uncertain significance (VUS) fundamentally limit the utility of genetic information in a clinical setting. The challenge of VUS is epitomized by BRCA1, a tumor suppressor gene integral to DNA repair and genomic stability. Germline BRCA1 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f964e7f1c9815ec367e262f7fb6a504d
Autor:
Joseph D. Janizek, Lea M. Starita, Beth Martin, Gregory M. Findlay, Jay Shendure, Xingfan Huang, Riza M. Daza, Melissa D. Zhang, Anh Leith, Molly Gasperini
Publikováno v:
Nature
Variants of uncertain significance fundamentally limit the clinical utility of genetic information. The challenge they pose is epitomized by BRCA1, a tumour suppressor gene in which germline loss-of-function variants predispose women to breast and ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7526134457be98929201c28d40c47256
https://pubmed.ncbi.nlm.nih.gov/33964677
https://pubmed.ncbi.nlm.nih.gov/33964677
Autor:
Darren A. Cusanovich, Choli Lee, Melissa D. Zhang, Molly Gasperini, Jay Shendure, Jennifer H. Milbank, Aaron McKenna, Gregory M. Findlay
Publikováno v:
American journal of human genetics. 101(2)
The extent to which non-coding mutations contribute to Mendelian disease is a major unknown in human genetics. Relatedly, the vast majority of candidate regulatory elements have yet to be functionally validated. Here, we describe a CRISPR-based syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79108502a9d23ebb29c34af2371671a9
https://pubmed.ncbi.nlm.nih.gov/28712454
https://pubmed.ncbi.nlm.nih.gov/28712454