Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Molly E. Woodson"'
Autor:
Dimitrios Moianos, Maria Makri, Georgia-Myrto Prifti, Aristeidis Chiotellis, Alexandros Pappas, Molly E. Woodson, Razia Tajwar, John E. Tavis, Grigoris Zoidis
Publikováno v:
Molecules, Vol 29, Iss 12, p 2942 (2024)
Hepatitis B virus (HBV) remains a global health threat. Ribonuclease H (RNase H), part of the virus polymerase protein, cleaves the pgRNA template during viral genome replication. Inhibition of RNase H activity prevents (+) DNA strand synthesis and r
Externí odkaz:
https://doaj.org/article/92d2fc12da214c62bb8eb197a88cae60
Autor:
Daniel V. Schiavone, Diana M. Kapkayeva, Qilan Li, Molly E. Woodson, Andreu Gazquez Casals, Lynda A. Morrison, John E. Tavis, Ryan P. Murelli
Publikováno v:
Chemistry
Polyoxygenated tropolones possess a broad range of biological activity, and as a result are promising lead structures or fragments for drug development. However, structure-function studies and subsequent optimization have been challenging, in part du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5e8d6296875d885c8561e019f36687
https://europepmc.org/articles/PMC8858858/
https://europepmc.org/articles/PMC8858858/
Autor:
Austin T O'Dea, Nathan L. Ponzar, John E. Tavis, Molly E Woodson, Bruce L Rogers, Daniel P Bradley, Ryan P. Murelli, Alaina Knier, Qilan Li
Publikováno v:
Antimicrob Agents Chemother
The α-hydroxytropolones (αHTs) are troponoid inhibitors of hepatitis B virus (HBV) replication that can target HBV RNase H with submicromolar efficacies. αHTs and related troponoids (tropones and tropolones) can be cytotoxic in cell lines as measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6696a7e64c277ee7f73da06f83f52f
https://europepmc.org/articles/PMC8765277/
https://europepmc.org/articles/PMC8765277/
Autor:
Shuo, Wang, Yujie, Ren, Qilan, Li, Ya, Wang, Xiangyi, Jiang, Shujing, Xu, Xujie, Zhang, Shujie, Zhao, Daniel P, Bradley, Molly E, Woodson, Fabao, Zhao, Shuo, Wu, Yuhuan, Li, Ye, Tian, Xinyong, Liu, John E, Tavis, Peng, Zhan
Publikováno v:
Bioorganic Chemistry. 129:106192
Capsid assembly modulators (CAMs) represent a novel class of antiviral agents targeting hepatitis B virus (HBV) capsid to disrupt the assembly process. NVR 3-778 is the first CAM to demonstrate antiviral activity in patients infected with HBV. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a16fdb9e703f8f489f7287cf6f5901
https://doi.org/10.1016/j.bioorg.2022.106192
https://doi.org/10.1016/j.bioorg.2022.106192
Publikováno v:
Antimicrob Agents Chemother
The hepatitis B virus (HBV) ribonuclease H (RNase H) is an attractive but unexploited drug target. Here, we addressed three limitations to the current state of RNase H inhibitor development: (a) Efficacy has been assessed only in transfected cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c6ed9e1ab4a4c6e65da497e5b8d9b3
https://pubmed.ncbi.nlm.nih.gov/34516242
https://pubmed.ncbi.nlm.nih.gov/34516242
Autor:
Srinivasulu Cherukupalli, Yujie Ren, Molly E Woodson, Peng Zhan, Qilan Li, Xinyong Liu, John E. Tavis, Yue Ma, Shujie Zhao, Daniel P Bradley
Publikováno v:
European journal of medicinal chemistry. 225
GLS4, a potent antiviral drug candidate, has been widely studied and entered into phase II clinical trials. Nevertheless, the therapeutic application of GLS4 is limited due to poor water solubility, short half-life, and low bioavailability. In order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e785e0d903959803cb6138bfd7b77b1
https://pubmed.ncbi.nlm.nih.gov/34438123
https://pubmed.ncbi.nlm.nih.gov/34438123