Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Molly E. Woodson"'
Autor:
Dimitrios Moianos, Maria Makri, Georgia-Myrto Prifti, Aristeidis Chiotellis, Alexandros Pappas, Molly E. Woodson, Razia Tajwar, John E. Tavis, Grigoris Zoidis
Publikováno v:
Molecules, Vol 29, Iss 12, p 2942 (2024)
Hepatitis B virus (HBV) remains a global health threat. Ribonuclease H (RNase H), part of the virus polymerase protein, cleaves the pgRNA template during viral genome replication. Inhibition of RNase H activity prevents (+) DNA strand synthesis and r
Externí odkaz:
https://doaj.org/article/92d2fc12da214c62bb8eb197a88cae60
Autor:
Daniel V. Schiavone, Diana M. Kapkayeva, Qilan Li, Molly E. Woodson, Andreu Gazquez Casals, Lynda A. Morrison, John E. Tavis, Ryan P. Murelli
Publikováno v:
Chemistry
Polyoxygenated tropolones possess a broad range of biological activity, and as a result are promising lead structures or fragments for drug development. However, structure-function studies and subsequent optimization have been challenging, in part du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5e8d6296875d885c8561e019f36687
https://europepmc.org/articles/PMC8858858/
https://europepmc.org/articles/PMC8858858/
Autor:
Austin T O'Dea, Nathan L. Ponzar, John E. Tavis, Molly E Woodson, Bruce L Rogers, Daniel P Bradley, Ryan P. Murelli, Alaina Knier, Qilan Li
Publikováno v:
Antimicrob Agents Chemother
The α-hydroxytropolones (αHTs) are troponoid inhibitors of hepatitis B virus (HBV) replication that can target HBV RNase H with submicromolar efficacies. αHTs and related troponoids (tropones and tropolones) can be cytotoxic in cell lines as measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6696a7e64c277ee7f73da06f83f52f
https://europepmc.org/articles/PMC8765277/
https://europepmc.org/articles/PMC8765277/
Autor:
Shuo, Wang, Yujie, Ren, Qilan, Li, Ya, Wang, Xiangyi, Jiang, Shujing, Xu, Xujie, Zhang, Shujie, Zhao, Daniel P, Bradley, Molly E, Woodson, Fabao, Zhao, Shuo, Wu, Yuhuan, Li, Ye, Tian, Xinyong, Liu, John E, Tavis, Peng, Zhan
Publikováno v:
Bioorganic Chemistry. 129:106192
Capsid assembly modulators (CAMs) represent a novel class of antiviral agents targeting hepatitis B virus (HBV) capsid to disrupt the assembly process. NVR 3-778 is the first CAM to demonstrate antiviral activity in patients infected with HBV. Howeve
Publikováno v:
Antimicrob Agents Chemother
The hepatitis B virus (HBV) ribonuclease H (RNase H) is an attractive but unexploited drug target. Here, we addressed three limitations to the current state of RNase H inhibitor development: (a) Efficacy has been assessed only in transfected cell lin
Autor:
Srinivasulu Cherukupalli, Yujie Ren, Molly E Woodson, Peng Zhan, Qilan Li, Xinyong Liu, John E. Tavis, Yue Ma, Shujie Zhao, Daniel P Bradley
Publikováno v:
European journal of medicinal chemistry. 225
GLS4, a potent antiviral drug candidate, has been widely studied and entered into phase II clinical trials. Nevertheless, the therapeutic application of GLS4 is limited due to poor water solubility, short half-life, and low bioavailability. In order
Autor:
Moianos, Dimitrios1 (AUTHOR) moianosjim@pharm.uoa.gr, Makri, Maria1 (AUTHOR) mmakri@pharm.uoa.gr, Prifti, Georgia-Myrto1 (AUTHOR) geprifti@pharm.uoa.gr, Chiotellis, Aristeidis2 (AUTHOR) achiotel@rrp.demokritos.gr, Pappas, Alexandros2 (AUTHOR) alpappas@pharm.uoa.gr, Woodson, Molly E.3 (AUTHOR) molly.woodson@slu.edu, Tajwar, Razia3 (AUTHOR) razia.tajwar@health.slu.edu, Tavis, John E.3 (AUTHOR) john.tavis@health.slu.edu, Zoidis, Grigoris1 (AUTHOR) zoidis@pharm.uoa.gr
Publikováno v:
Molecules. Jun2024, Vol. 29 Issue 12, p2942. 32p.
Autor:
Schiavone, Daniel V.1,2 (AUTHOR), Kapkayeva, Diana M.1 (AUTHOR), Li, Qilan3 (AUTHOR), Woodson, Molly E.3 (AUTHOR), Gazquez Casals, Andreu3 (AUTHOR), Morrison, Lynda A.3 (AUTHOR), Tavis, John E.3 (AUTHOR), Murelli, Ryan P.1,2 (AUTHOR) rpmurelli@brooklyn.cuny.edu
Publikováno v:
Chemistry - A European Journal. 2/21/2022, Vol. 28 Issue 11, p1-6. 6p.
Publikováno v:
Hepatitis Weekly; 7/8/2024, p574-574, 1p