Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Molly D. Congdon"'
Autor:
Li, Xia, Tiffany R, Bellomo, Ruslan, Gibadullin, Molly D, Congdon, Elijah F, Edmondson, Mi, Li, Alexander, Wlodawer, Crystal, Li, J Sebastian, Temme, Pavan, Patel, Donna, Butcher, Jeffrey C, Gildersleeve
Publikováno v:
Journal of the American Chemical Society. 144(36)
Glycosylation is a vital post-translational modification involved in a range of biological processes including protein folding, signaling, and cell-cell interactions. In 2011, a new type of
Autor:
Sabrina A. Carter, Adam C Huckaby, Webster L. Santos, Molly D. Congdon, Jennifer M. McDaniels, Sabrina Lingeman, Pradipsinh K. Rathod, Audrey Francis, Jennifer L. Guler
Publikováno v:
Mol Microbiol
Molecular Microbiology
Molecular Microbiology
Extrachromosomal (ec) DNAs are genetic elements that exist separately from the genome. Since ecDNA can carry beneficial genes, they are a powerful adaptive mechanism in cancers and many pathogens. For the first time, we report ecDNA contributing to a
Publikováno v:
Bioconjug Chem
Biological conjugation is an important tool employed for many basic research and clinical applications. While useful, common methods of biological conjugation suffer from a variety of limitations, such as (a) requiring the presence of specific surfac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bced07807f6a8a1976b2db26e6c9c6ac
https://europepmc.org/articles/PMC9175515/
https://europepmc.org/articles/PMC9175515/
Autor:
Molly D. Congdon, Vlad Serbulea, Webster L. Santos, David R. Bevan, Yugesh Kharel, Anne M. Brown, Russell G. Fritzemeier, Kevin R. Lynch
Publikováno v:
Eur J Med Chem
Elevated levels of sphingosine 1-phosphate (S1P) and increased expression of sphingosine kinase isoforms (SphK1 and SphK2) have been implicated in a variety of disease states including cancer, inflammation, autoimmunity, among others. Consequently, t
Autor:
Kevin R. Lynch, Webster L. Santos, Molly D. Congdon, James Gumkowski, Emily A. Morris, Elizabeth S. Childress, Neeraj N. Patwardhan, Yugesh Kharel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4956-4960
Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P
Autor:
Kevin R. Lynch, Jose L. Tomsig, Molly D. Congdon, Steven B. Thorpe, Yugesh Kharel, Emily A. Morris, Webster L. Santos
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 355:23-31
Sphingosine 1-phosphate (S1P) levels are significantly higher in blood and lymph than in tissues. This S1P concentration difference is necessary for proper lymphocyte egress from secondary lymphoid tissue and to maintain endothelial barrier integrity
Autor:
Stephanie N. Lewis, Webster L. Santos, Anne M. Brown, Yugesh Kharel, David R. Bevan, Kevin R. Lynch, Molly D. Congdon
Publikováno v:
ACS medicinal chemistry letters. 7(3)
The two isoforms of sphingosine kinase (SphK1 and SphK2) are the only enzymes that phosphorylate sphingosine to sphingosine-1-phosphate (S1P), which is a pleiotropic lipid mediator involved in a broad range of cellular processes including migration,