Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Molly C. Sutherland"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Heme trafficking is essential for cellular function, yet mechanisms of transport and/or heme interaction are not well defined. The System I and System II bacterial cytochrome c biogenesis pathways are developing into model systems for heme t
Externí odkaz:
https://doaj.org/article/def7cd7a4f7d41d4905ef0a02e7b9a10
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTHeme trafficking is a fundamental biological process, yet its direct study has been hampered due to heme’s tight intracellular regulation, heme cytotoxicity, and the transient nature of trafficking. The bacterial System I and System II cyto
Externí odkaz:
https://doaj.org/article/5f2393c5971e4c4eb9d52935a85a0629
Autor:
Jessica L. Keffer, Sean M. McAllister, Arkadiy I. Garber, Beverly J. Hallahan, Molly C. Sutherland, Sharon Rozovsky, Clara S. Chan
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Iron (Fe) oxidation is one of Earth’s major biogeochemical processes, key to weathering, soil formation, water quality, and corrosion. However, our understanding of microbial contribution is limited by incomplete knowledge of microbial iro
Externí odkaz:
https://doaj.org/article/5e4619a44bb34d8592b27f6eca18c546
In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases
Autor:
Molly C Sutherland, Deanna L Mendez, Shalon E Babbitt, Dustin E Tillman, Olga Melnikov, Nathan L Tran, Noah T Prizant, Andrea L Collier, Robert G Kranz
Publikováno v:
eLife, Vol 10 (2021)
Cytochromes c are ubiquitous heme proteins in mitochondria and bacteria, all possessing a CXXCH (CysXxxXxxCysHis) motif with covalently attached heme. We describe the first in vitro reconstitution of cytochrome c biogenesis using purified mitochondri
Externí odkaz:
https://doaj.org/article/38a15e89d2074dfa85e4e1de505ca636
Autor:
Dinesh Gupta, Molly C. Sutherland, Karthikeyan Rengasamy, J. Mark Meacham, Robert G. Kranz, Arpita Bose
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Photoferrotrophy is a form of anoxygenic photosynthesis whereby bacteria utilize soluble or insoluble forms of ferrous iron as an electron donor to fix carbon dioxide using light energy. They can also use poised electrodes as their electron
Externí odkaz:
https://doaj.org/article/0fc9d910441646119715d3f781b3a168
Autor:
Molly C. Sutherland, Nathan L. Tran, Dustin E. Tillman, Joshua M. Jarodsky, Jason Yuan, Robert G. Kranz
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Although intracellular heme trafficking must occur for heme protein assembly, only a few heme transporters have been unequivocally discovered and nothing is known about their structure or mechanisms. Cytochrome c biogenesis in prokaryotes re
Externí odkaz:
https://doaj.org/article/667789d6d01e4816a989bb122bd77ac4
Autor:
Deanna L. Mendez, Ethan P. Lowder, Dustin E. Tillman, Molly C. Sutherland, Andrea L. Collier, Michael J. Rau, James A. J. Fitzpatrick, Robert G. Kranz
Publikováno v:
Nature chemical biology. 18(1)
Although the individual structures and respiratory functions of cytochromes are well studied, the structural basis for their assembly, including transport of heme for attachment, are unknown. We describe cryo-electron microscopy (cryo-EM) structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d590d2cf4026ac0ebb248d0f5d246c76
https://pubmed.ncbi.nlm.nih.gov/34931065
https://pubmed.ncbi.nlm.nih.gov/34931065
In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases
Autor:
Dustin E Tillman, Noah T Prizant, Olga Melnikov, Robert G. Kranz, Molly C. Sutherland, Deanna L. Mendez, Shalon E. Babbitt, Nathan L. Tran, Andrea L Collier
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Cytochromes c are ubiquitous heme proteins in mitochondria and bacteria, all possessing a CXXCH (CysXxxXxxCysHis) motif with covalently attached heme. We describe the first in vitro reconstitution of cytochrome c biogenesis using purified mitochondri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b938b93993465243a7e1bd87685190
https://doi.org/10.7554/elife.64891
https://doi.org/10.7554/elife.64891
Autor:
Deanna L. Mendez, Olga Melnikov, Nathan L. Tran, Robert G. Kranz, Shalon E. Babbitt, Andrea L Collier, Molly C. Sutherland, Dustin E Tillman, Noah T Prizant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e71716c6c108812f66f26138c935e07c
https://doi.org/10.7554/elife.64891.sa2
https://doi.org/10.7554/elife.64891.sa2
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65529 (2013)
Legionella pneumophila, the causative agent of a severe pneumonia termed Legionnaires' Disease, survives and replicates within both protozoan hosts and human alveolar macrophages. Intracellular survival is dependent upon secretion of a plethora of pr
Externí odkaz:
https://doaj.org/article/0b025a2248704dc59958317282baf19e