Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Molly C. Kottemann"'
Autor:
Brooke A. Conti, Penelope D. Ruiz, Cayla Broton, Nicolas J. Blobel, Molly C. Kottemann, Sunandini Sridhar, Francis P. Lach, Tom F. Wiley, Nanda K. Sasi, Thomas Carroll, Agata Smogorzewska
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract DNA replication through a challenging genomic landscape is coordinated by the replisome, which must adjust to local conditions to provide appropriate replication speed and respond to lesions that hinder its progression. We have previously sh
Externí odkaz:
https://doaj.org/article/bb0f43ef23d34a678edc5ee4e00c721c
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 207-215 (2013)
Holliday junctions (HJs), the DNA intermediates of homologous recombination, need to be faithfully processed in order to preserve genome integrity. In human cells, the BLM helicase complex promotes nonnucleolytic dissolution of double HJs. In vitro,
Externí odkaz:
https://doaj.org/article/f800f285810941d2bf0ae88229364c3d
Autor:
Brooke A. Conti, Penelope D. Ruiz, Cayla Broton, Nicolas J. Blobel, Molly C. Kottemann, Sunandini Sridhar, Francis P. Lach, Tom Wiley, Nanda K. Sasi, Thomas Carroll, Agata Smogorzewska
Publikováno v:
bioRxiv
Genetic information is duplicated via the highly regulated process of DNA replication. The machinery coordinating this process, the replisome, encounters many challenges, including replication fork-stalling lesions that threaten the accurate and time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da392f37a28108837fa33207a1cb1cd
https://europepmc.org/articles/PMC10054921/
https://europepmc.org/articles/PMC10054921/
Publikováno v:
Development.
During Drosophila oogenesis, specialized actin-based structures called ring canals form and expand to accommodate growth of the oocyte. Previous work demonstrated that Kelch and Cullin 3 function together in a Cullin 3-RING ubiquitin ligase complex (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865582c274405f4f7fdba8dc37a9dfd7
https://doi.org/10.1242/dev.169219
https://doi.org/10.1242/dev.169219
Publikováno v:
Molecular cell. 69(1)
The protection and efficient restart of stalled replication forks is critical for the maintenance of genome integrity. Here, we identify a regulatory pathway that promotes stalled forks recovery from replication stress. We show that the mammalian rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e661e5e18f0f3c792e8381059ef1ce
https://pubmed.ncbi.nlm.nih.gov/29290612
https://pubmed.ncbi.nlm.nih.gov/29290612
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 207-215 (2013)
SummaryHolliday junctions (HJs), the DNA intermediates of homologous recombination, need to be faithfully processed in order to preserve genome integrity. In human cells, the BLM helicase complex promotes nonnucleolytic dissolution of double HJs. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be10b718ec38bf5ec9bdf68da32dd5b
Autor:
Jocelyne DiRuggiero, Nitin S. Baliga, Chika Iloanusi, Min Pan, Sarah J. Bjork, Leroy Hood, Richard Bonneau, Molly C. Kottemann
Publikováno v:
Genome Research. 14:1025-1035
We report a remarkably high UV-radiation resistance in the extremely halophilic archaeonHalobacterium NRC-1withstanding up to 110 J/m2with no loss of viability. Gene knockout analysis in two putative photolyase-like genes (phr1andphr2) implicated onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3bee2e43f5104384ce8b61472a8402
https://doi.org/10.1101/gr.1993504
https://doi.org/10.1101/gr.1993504
Autor:
Molly C. Kottemann
Publikováno v:
Postdoc Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5c1c867026bfa36a89c8c786c0a979e
https://doi.org/10.14304/surya.jpr.v1n10.5
https://doi.org/10.14304/surya.jpr.v1n10.5
Autor:
Molly C. Kottemann, Agata Smogorzewska
Publikováno v:
Nature. 493(7432)
The function of Fanconi anaemia proteins is to maintain genomic stability. Their main role is in the repair of DNA interstrand crosslinks, which, by covalently binding the Watson and the Crick strands of DNA, impede replication and transcription. Ina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f267de70b9694a52cf99f5734aa723
https://pubmed.ncbi.nlm.nih.gov/23325218
https://pubmed.ncbi.nlm.nih.gov/23325218
Autor:
Molly C. Kottemann, Allen E. Bale
MEN1 , the gene responsible for the cancer predisposition syndrome multiple endocrine neoplasia type I, has been implicated in DNA repair, cell cycle control, and transcriptional regulation. It is unclear to what degree these processes are integrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be71776d39420b54c17c35081fa23f29
https://europepmc.org/articles/PMC2745199/
https://europepmc.org/articles/PMC2745199/