The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34

Autor: Berta Vidal, Burcu Gulez, Wen Xi Cao, Eduardo Leyva-Díaz, Molly B Reilly, Tessa Tekieli, Oliver Hobert

Publikováno v: eLife. 11

Overarching themes in the terminal differentiation of the enteric nervous system, an autonomously acting unit of animal nervous systems, have so far eluded discovery. We describe here the overall regulatory logic of enteric nervous system differentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b602ea64ecb1ea693d10c2fd34bbaa87
https://doi.org/10.7554/elife.76003

Unique homeobox codes delineate all the neuron classes of C. elegans

Autor: Oliver Hobert, Eviatar Yemini, Cyril Cros, Erdem Varol, Molly B. Reilly

Publikováno v: Nature

It is not known at present whether neuronal cell-type diversity—defined by cell-type-specific anatomical, biophysical, functional and molecular signatures—can be reduced to relatively simple molecular descriptors of neuronal identity1. Here we sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99f58f0f3964f69dad428677b22f6a1
https://doi.org/10.1038/s41586-020-2618-9

In silico analysis of the transcriptional regulatory logic of neuronal identity specification throughout the C. elegans nervous system

Autor: Marc Hammarlund, Laura Pereira, Molly B. Reilly, Nenad Sestan, Eviatar Yemini, Seth R. Taylor, Manasa Basavaraju, Lori Glenwinkel, Roger Pocock, Oliver Hobert, Ibnul Rafi, Kasper Langebeck-Jensen, David M. Miller

Publikováno v: eLife
Glenwinkel, L, Taylor, S R, Langebeck-Jensen, K, Pereira, L, Reilly, M B, Basavaraju, M, Rafi, I, Yemini, E, Pocock, R, Sestan, N, Hammarlund, M, Miller, D M & Hobert, O 2021, ' In silico analysis of the transcriptional regulatory logic of neuronal identity specification throughout the c. Elegans nervous system ', eLife, vol. 10, e64906, pp. 1-29 . https://doi.org/10.7554/eLife.64906
eLife, Vol 10 (2021)

The generation of the enormous diversity of neuronal cell types in a differentiating nervous system entails the activation of neuron type-specific gene batteries. To examine the regulatory logic that controls the expression of neuron type-specific ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ada1d3f86da46d0b2b940e043a9073
http://europepmc.org/articles/PMC8225391

Molecular topography of an entire nervous system

Autor: Molly B. Reilly, Cyril Cros, Marc Hammarlund, Seth R. Taylor, Alec Barrett, Gabriel Santpere, Saeed Tavazoie, Alexander J. Abrams, Abigail Poff, Lori Glenwinkel, Manasa Basavaraju, Oliver Hobert, Chuan Xu, Erdem Varol, David M. Miller, Eviatar Yemini, Rebecca McWhirter, Panos Oikonomou, Nenad Sestan, Berta Vidal, Ibnul Rafi, Steven J. Cook, Alexis Weinreb

SummaryNervous systems are constructed from a deep repertoire of neuron types but the underlying gene expression programs that specify individual neuron identities are poorly understood. To address this deficit, we have produced an expression profile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::178dcc6aa3d8f653a5c599e913d3eb51
https://doi.org/10.1101/2020.12.15.422897

Expression profiling of the mature C. elegans nervous system by single-cell RNA-Sequencing

Autor: Steven J. Cook, Chuan Xu, David M. Miller, Manasa Basavaraju, Nenad Sestan, Seth R. Taylor, Oliver Hobert, Gabriel Santpere, Molly B. Reilly, Lori Glenwinkel, Alec Barrett, Alexander J. Abrams, Rebecca McWhirter, Marc Hammarlund, Berta Vidal, Cyril Cros, Ibnul Rafi, Alexis Weinreb, Abigail Poff

A single neuron and its synapses define the fundamental structural motif of the brain but the underlying gene expression programs that specify individual neuron types are poorly understood. To address this question in a model organism, we have produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646fb7edfb9daeb903b0441cefcb63c2
https://doi.org/10.1101/737577