Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Molly A. McNamara"'
Publikováno v:
Urology Case Reports, Vol 45, Iss , Pp 102209- (2022)
Splenosis refers to the benign heterotopic auto transplantation of splenic tissue that most commonly arises following traumatic rupture of the spleen. It is most often associated with traumatic rupture of the spleen. While often asymptomatic, splenos
Externí odkaz:
https://doaj.org/article/3e462f4d5ddb4f149dd08fc7103e02a9
Autor:
Molly C. McNamara, Aaron M. Hosios, Margaret E. Torrence, Ting Zhao, Cameron Fraser, Meghan Wilkinson, David J. Kwiatkowski, Elizabeth P. Henske, Chin-Lee Wu, Kristopher A. Sarosiek, Alexander J. Valvezan, Brendan D. Manning
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105458- (2022)
Summary: mTORC1 is aberrantly activated in cancer and in the genetic tumor syndrome tuberous sclerosis complex (TSC), which is caused by loss-of-function mutations in the TSC complex, a negative regulator of mTORC1. Clinically approved mTORC1 inhibit
Externí odkaz:
https://doaj.org/article/1546eb080b7a4a7f9f6f0f9c3783ba12
Autor:
Aaron M. Hosios, Meghan E. Wilkinson, Molly C. McNamara, Krystle C. Kalafut, Margaret E. Torrence, John M. Asara, Brendan D. Manning
Publikováno v:
Nat Metab
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) senses and relays environmental signals from growth factors and nutrients to metabolic networks and adaptive cellular systems to control the synthesis and breakdown of macromolecules. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b2163e0d8b1bfa8bc47f3e1b50d527
https://doi.org/10.1038/s42255-022-00706-6
https://doi.org/10.1038/s42255-022-00706-6
Publikováno v:
Journal of Surgical Case Reports. 2022
Colonic intussusception is a rare occurrence in adults, with few reported cases in the literature. Patients often present with nonspecific and vague symptoms leading to diagnostic challenges and delayed treatment. Given the high incidence of underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45b2e938664aa1199b99a1669cec4ce4
https://doi.org/10.1093/jscr/rjac104
https://doi.org/10.1093/jscr/rjac104
Autor:
Alexander J. Valvezan, Brendan D. Manning, Spencer K. Miller, John M. Asara, Molly C. McNamara, Margaret E. Torrence, Elizabeth P. Henske
Publikováno v:
JCI Insight
Recent studies in distinct preclinical tumor models have established the nucleotide synthesis enzyme inosine-5'-monophosphate dehydrogenase (IMPDH) as a viable target for antitumor therapy. IMPDH inhibitors have been used clinically for decades as sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7ed6c508929c57cc37aac6fd047867
https://pubmed.ncbi.nlm.nih.gov/32271165
https://pubmed.ncbi.nlm.nih.gov/32271165
Autor:
John M. Asara, Elizabeth P. Henske, Spencer K. Miller, Margaret E. Torrence, Molly C. McNamara, Alexander J. Valvezan, Brendan D. Manning
Structured AbstractPurposemTORC1 is a master regulator of anabolic cell growth and proliferation that is activated in the majority of human tumors. We recently demonstrated that elevated mTORC1 activity in cells and tumors can confer dependence on IM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfe24b3e7599e9ec2658d2dedfbd778
Autor:
Gary L. Pierce, Matthew J. Rossman, Molly N. McNamara, Jessica R. Santos-Parker, Sierra D. Hill, Anthony J. Donato, Rachelle E. Kaplon, Douglas R. Seals
Cellular senescence is emerging as a key mechanism of age-related vascular endothelial dysfunction, but evidence in healthy humans is lacking. Moreover, the influence of lifestyle factors such as habitual exercise on endothelial cell (EC) senescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f33365c1418f24bb9f2f6359a2045cd
https://europepmc.org/articles/PMC5792201/
https://europepmc.org/articles/PMC5792201/