Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Molly A. McGlynn"'
A practical and stereoselective synthesis of (+/−)-trans-4-benzyloctahydropyrrolo[3,4-b][1,4]oxazine
Publikováno v:
Journal of Heterocyclic Chemistry. 47:1095-1103
Starting from commercially available cis-epoxysuccinic acid (I) a facile stereoselective synthesis of title compound (V) is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67fb1e74cc21e28a3cc1756953433330
https://doi.org/10.1002/jhet.476
https://doi.org/10.1002/jhet.476
Autor:
Daniel P. Walker, Daniel W. Kung, Anil Mistry, Michael P. Zawistoski, Seungil Han, Jian-Cheng Li, Janet A. Houser, Jason Boer, Amy P. Baumann, Leonard Buckbinder, Molly A. McGlynn, Peter C. Bonnette, Angel Guzman-Perez, Li Xing
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3253-3258
The synthesis, in vitro properties, and in vivo pharmacokinetics for a series of sulfoximine-substituted trifluoromethylpyrimidines as inhibitors of proline-rich tyrosine kinase, a target for the possible treatment of osteoporosis, are described. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f40c7f299d748ce7e78354bf6d599f
https://doi.org/10.1016/j.bmcl.2009.04.093
https://doi.org/10.1016/j.bmcl.2009.04.093
Autor:
James H. Roache, Eric B. McElroy, Timothy Joseph Paradis, Aikomari Guzman-Martinez, Sara A. Burrell, Robert S. Foti, Matthew Frank Brown, Greg D. Lundquist, Kevin B. Bahnck, James P. Driscoll, Andrei Shavnya, Laurie Tylaska, Ronald P. Gladue, Michael B. Fisher, Poss Christopher Stanley, Molly A. McGlynn, William H. Brissette, Yi Lu, Brett M. Lillie, Laura Cook Blumberg, Flavia Fedeles, Matthew Merrill Hayward, Richard M. Shepard, Kristen A. Trevena, Paul D. Lira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3109-3112
The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7092f68daaded6a7d772a046b3e18482
https://doi.org/10.1016/j.bmcl.2007.03.037
https://doi.org/10.1016/j.bmcl.2007.03.037
Autor:
Matthew Frank Brown, William H. Brissette, Amy P DiRico, Eric B. McElroy, Ronald P. Gladue, Timothy Joseph Paradis, Laurie Tylaska, Maryrose J. Conklyn, Deye Zheng, Erin N Mairs, John Charles Kath, Poss Christopher Stanley, Molly A. McGlynn, Dorff Peter H, William H. Martin, Brett M. Lillie, Ingrid A. Stock, Paul D. Lira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2169-2173
The present manuscript details structure-activity relationship studies of lead structure 1, which led to the discovery of CCR1 antagonists >100-fold more potent than 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef990508ecff58522de63097d9a8e3d
https://doi.org/10.1016/j.bmcl.2004.02.021
https://doi.org/10.1016/j.bmcl.2004.02.021
Autor:
Molly A. McGlynn, Matthew Frank Brown, Stacie P. O'Sullivan, Anthony Marfat, John B. Cheng, Theodore E. Liston, John W. Watson, J.S. Pillar, David B. Damon, J.T. Shirley, R. J. Chambers, Gerard Antognoli, Brian S. Owens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2451-2456
Exploration of the indole nitrogen region of Zafirlukast (1) has uncovered a potent series of cysteinyl leukotriene D4 (LTD4) antagonists. These studies showed that a variety of functionality could be incorporated in this region of the molecule witho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ca40ed0f31d3457b3dd5a3ad8f6482
https://doi.org/10.1016/s0960-894x(98)00442-9
https://doi.org/10.1016/s0960-894x(98)00442-9
Publikováno v:
ChemInform. 42
Starting from commercially available cis-epoxysuccinic acid (I) a facile stereoselective synthesis of title compound (V) is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1691e2ba0d9094b0eb001e25c965f2
https://doi.org/10.1002/chin.201107194
https://doi.org/10.1002/chin.201107194
Autor:
Matthew F. Dunn, John Charles Kath, Anil Mistry, F. Christopher Bi, Daniel Tyler Richter, Sabrina X. Zhao, Leonard Buckbinder, Jacquelyn Klug-McLeod, Daniel W. Kung, Gary Erik Aspnes, Michael P. Zawistoski, Robert M. Oliver, Seungil Han, Peter C. Bonnette, Ethan Ung, Molly A. McGlynn, Angel Guzman-Perez, Catherine Angela Hulford, Matthew C. Griffor, John R. Soglia, Jonathan N. Bauman, Michael Joseph Luzzio, Daniel P. Walker, Christopher Autry, Amit S. Kalgutkar, W. Gregory Roberts, Jian-Cheng Li, Beth Cooper
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(23)
The synthesis and SAR for a series of diaminopyrimidines as PYK2 inhibitors are described. Using a combination of library and traditional medicinal chemistry techniques, a FAK-selective chemical series was transformed into compounds possessing good P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d4e40768ab5124987956906e550066
https://pubmed.ncbi.nlm.nih.gov/18951788
https://pubmed.ncbi.nlm.nih.gov/18951788
Autor:
Poss Christopher Stanley, Molly A. McGlynn, Truesdell Susan Jane, Maryrose J. Conklyn, Suzanne S Krueger, William H. Brissette, Matthew Frank Brown, Timothy J. Strelevitz, Timothy Joseph Paradis, Kwansik Yoon, John Charles Kath, Eric B. McElroy, Mike Avery, Richard M. Shepard, Michelle Rossulek, Laurie Tylaska, Jeff Sims, Kevin Colizza, Ronald P. Gladue, Deye Zheng, Greg D. Lundquist, Erin N Mairs, Amy P DiRico, Brett M. Lillie, Paul D. Lira, J.H Chang
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(9)
The synthesis, biological activity, and pharmacokinetic profile of novel CCR1 antagonists are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8796dcf1eb5be0c84b0970136c821e02
https://pubmed.ncbi.nlm.nih.gov/15081003
https://pubmed.ncbi.nlm.nih.gov/15081003
Autor:
William H. Brissette, Timothy Joseph Paradis, Poss Christopher Stanley, Matthew Frank Brown, Paul D. Lira, Molly A. McGlynn, Brett M. Lillie, Richard M. Shepard, Ronald P. Gladue, Maryrose J. Conklyn, Kuldeep S. Neote, Eric B. McElroy, John Charles Kath, Henry J. Showell, Ingrid A. Stock, Laurie Tylaska, William H. Martin, Erin N Mairs, Amy P DiRico, Ogborne Kevin Thomas
Publikováno v:
The Journal of biological chemistry. 278(42)
The chemokines CCL3 and CCL5, as well as their shared receptor CCR1, are believed to play a role in the pathogenesis of several inflammatory diseases including rheumatoid arthritis, multiple sclerosis, and transplant rejection. In this study we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ee1922fcb9337aefcd919fb32f9314
https://pubmed.ncbi.nlm.nih.gov/12909630
https://pubmed.ncbi.nlm.nih.gov/12909630