Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Molly A McShea"'
Autor:
Emma Lees, William R. Sellers, Seth A. Ettenberg, Jeffrey A. Engelman, Francesco Hofmann, Juliet Williams, Hui Gao, Xiuxia Sun, Molly A. McShea, Kalli C. Catcott, Nicholas C. Yoder, Vivien W. Chan, Mary J. Janatpour, Jason E. Faris, Matthew J. Meyer, Aaron Bourret, Duc Nguyen, Markus Kurz, William R. Tschantz, Anne Serdakowski London, Tina Rubic-Schneider, Emily K. Meseck, Keith G. Mansfield, Meghan M. Flaherty, Jessica C. Piel, Artur Veloso, GiNell Elliott, Joel P. Wagner, Wei Jiang, Vladimir Capka, Ivana Liric Rajlic, Sanela Bilic, Tiancen Hu, Lance Ostrom, David Lee, Rebecca Mosher, Yeonju Shim, Pierric Prieur, Bruno Lafont, Clemens Dürr, Xiamei Zhang, Parmita Saxena, Xiao Li, Scott D. Collins, Carl U. Bialucha
This file describes supplementary material and methods used.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d44657d8d2fbce35e6a00e8c0ee3cc8
https://doi.org/10.1158/2159-8290.22531925
https://doi.org/10.1158/2159-8290.22531925
Autor:
Emma Lees, William R. Sellers, Seth A. Ettenberg, Jeffrey A. Engelman, Francesco Hofmann, Juliet Williams, Hui Gao, Xiuxia Sun, Molly A. McShea, Kalli C. Catcott, Nicholas C. Yoder, Vivien W. Chan, Mary J. Janatpour, Jason E. Faris, Matthew J. Meyer, Aaron Bourret, Duc Nguyen, Markus Kurz, William R. Tschantz, Anne Serdakowski London, Tina Rubic-Schneider, Emily K. Meseck, Keith G. Mansfield, Meghan M. Flaherty, Jessica C. Piel, Artur Veloso, GiNell Elliott, Joel P. Wagner, Wei Jiang, Vladimir Capka, Ivana Liric Rajlic, Sanela Bilic, Tiancen Hu, Lance Ostrom, David Lee, Rebecca Mosher, Yeonju Shim, Pierric Prieur, Bruno Lafont, Clemens Dürr, Xiamei Zhang, Parmita Saxena, Xiao Li, Scott D. Collins, Carl U. Bialucha
This file contains supplementary tables describing parameters for antitumor activity (T/C analyses), PK and protein crystallography.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c846a62ad61c836d71d14a89443dcfc
https://doi.org/10.1158/2159-8290.22531922.v1
https://doi.org/10.1158/2159-8290.22531922.v1
Autor:
Emma Lees, William R. Sellers, Seth A. Ettenberg, Jeffrey A. Engelman, Francesco Hofmann, Juliet Williams, Hui Gao, Xiuxia Sun, Molly A. McShea, Kalli C. Catcott, Nicholas C. Yoder, Vivien W. Chan, Mary J. Janatpour, Jason E. Faris, Matthew J. Meyer, Aaron Bourret, Duc Nguyen, Markus Kurz, William R. Tschantz, Anne Serdakowski London, Tina Rubic-Schneider, Emily K. Meseck, Keith G. Mansfield, Meghan M. Flaherty, Jessica C. Piel, Artur Veloso, GiNell Elliott, Joel P. Wagner, Wei Jiang, Vladimir Capka, Ivana Liric Rajlic, Sanela Bilic, Tiancen Hu, Lance Ostrom, David Lee, Rebecca Mosher, Yeonju Shim, Pierric Prieur, Bruno Lafont, Clemens Dürr, Xiamei Zhang, Parmita Saxena, Xiao Li, Scott D. Collins, Carl U. Bialucha
This file contains the figure legends for supplementary figures S1-S7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c4eef9f089f00def2dc18a4bc3cd01
https://doi.org/10.1158/2159-8290.22531931.v1
https://doi.org/10.1158/2159-8290.22531931.v1
Autor:
Keith Mansfield, Carl Uli Bialucha, Jeffrey A. Engelman, Kalli C. Catcott, William R. Sellers, Vivien W. Chan, Rebecca Mosher, Duc Nguyen, Pierric Prieur, Hui Gao, Seth Ettenberg, Tiancen Hu, Joel Wagner, Clemens Dürr, Jessica C. Piel, Anne Serdakowski London, Mary J. Janatpour, Sanela Bilic, William R. Tschantz, Bruno Lafont, Wei Jiang, Juliet Williams, GiNell Elliott, Yeonju Shim, Vladimir Capka, Meghan Flaherty, Matthew J. Meyer, Francesco Hofmann, Lance Ostrom, Artur Veloso, David M. Lee, Markus Kurz, Jason E. Faris, Emily K. Meseck, Ivana Liric Rajlic, Aaron Bourret, Xiao Li, Scott D. Collins, Xiuxia Sun, Molly A. McShea, Xiamei Zhang, Tina Rubic-Schneider, Nicholas C. Yoder, Parmita Saxena, Emma Lees
Publikováno v:
Cancer Discovery. 7:1030-1045
Despite an improving therapeutic landscape, significant challenges remain in treating the majority of patients with advanced ovarian or renal cancer. We identified the cell–cell adhesion molecule cadherin-6 (CDH6) as a lineage gene having significa
Autor:
Daniel Tavares, Nicholas C. Yoder, Shan Jin, Wayne C. Widdison, Lintao Wang, Hans K. Erickson, Kathleen R. Whiteman, Molly A. McShea, Chen Bai, Erin K. Maloney, Olga Ab, Thomas A. Keating, John M. Lambert, Sharon D. Wilhelm, Alan Wilhelm
Publikováno v:
Molecular pharmaceutics. 16(9)
Antibody-drug conjugates are an emerging class of cancer therapeutics constructed from monoclonal antibodies conjugated with small molecule effectors. First-generation molecules of this class often employed heterogeneous conjugation chemistry, but ma
Autor:
Molly A. McShea, Ravi V. J. Chari, Nicholas C. Yoder, Erin K. Maloney, Emily E. Reid, Leanne Lanieri, Jose F. Ponte, Katie E. Archer, Olga Ab, Alan Wilhelm, Manami Shizuka, Michael L. Miller
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(17)
Antibody-drug conjugates (ADCs) incorporating potent indolinobenzodiazepine (IGN) DNA alkylators as the cytotoxic payload are currently undergoing clinical evaluation. The optimized design of these payloads consists of an unsymmetrical dimer possessi
Autor:
Mikias Woldegiorgis, Fleming Michael, Chen Bai, Molly A. McShea, Seth Ettenberg, Carl Uli Bialucha, Nicholas C. Yoder, Hans K. Erickson, Kalli C. Catcott, Parmita Saxena, Stuart W. Hicks, Thomas G. Gesner, Kathy Miller, Megan E Lewis
Publikováno v:
mAbs. 8:513-523
Antibody-drug conjugates (ADCs) are of great interest as targeted cancer therapeutics. Preparation of ADCs for early stage screening is constrained by purification and biochemical analysis techniques that necessitate burdensome quantities of antibody
Autor:
Brad R. Pearse, Michael P. Cooke, Rahul Palchaudhuri, Sharon L. Hyzy, Kevin A. Goncalves, Jennifer L. Proctor, Hillary L. Adams, Megan D. Hoban, Anthony E. Boitano, Rajiv Panwar, Sean McDonough, Adam J. Hartigan, Molly A McShea
Publikováno v:
Biology of Blood and Marrow Transplantation. 24:S47-S48
Autor:
Rahul Palchaudhuri, Ganapathy N. Sarma, Bradley R. Pearse, Jennifer L. Proctor, Qing Li, Lena Kien, Junia Dushime, Nathan M Kallen, Pranoti Sawant, Michael P. Cooke, Anthony E. Boitano, Sharon L. Hyzy, Rajiv Panwar, Sean McDonough, Melissa L. Brooks, Molly A McShea, Charlotte Mcdonagh, Hillary L. Adams
Publikováno v:
Blood. 132:3314-3314
Background: Genotoxic conditioning prior to allogeneic and autologous bone marrow transplantation (BMT) limits the use of these potentially curative treatments due to risks of regimen-related morbidities and mortality, including risks of organ toxici
Autor:
Rajiv Panwar, Sean McDonough, Geoff O Gillard, Qing Li, Anthony E. Boitano, Charlotte Mcdonagh, Sharon Aslanian, Hillary L. Adams, Sharon L. Hyzy, Andrew D Gabros, Anjali Bhat, Molly A McShea, Pranoti Sawant, Rahul Palchaudhuri, Danielle Ladwig, Patrick C. Falahee, Ganapathy N. Sarma, Lena Kien, Michael P. Cooke, Bradley R. Pearse, Tahirih L. Lamothe, Jennifer L. Proctor, Junia Dushime, Nathan M Kallen, Melissa L. Brooks
Publikováno v:
Blood. 132:4526-4526
Introduction Bone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders and has demonstrated impressive outcomes in autoimmune diseases. Prior to BMT, patients are prepared with high-dose chemothe