Combination Therapy for HIV-Associated Cryptococcal Meningitis-A Success Story

Autor: Hurt, WJ, Harrison, TS, Molloy, SF, Bicanic, TA

Cryptococcal meningitis is the leading cause of adult meningitis in patients with HIV, and accounts for 15% of all HIV-related deaths in sub-Saharan Africa. The mainstay of management is effective antifungal therapy, despite a limited arsenal of anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::10ab371cf2cbd08697dbddf136cfae53

Healthcare Costs and Life-years Gained From Treatments Within the Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) Trial on Cryptococcal Meningitis: A Comparison of Antifungal Induction Strategies in Sub-Saharan Africa

Autor: Chen, T, Mwenge, L, Lakhi, S, Chanda, D, Mwaba, P, Molloy, SF, Gheorghe, A, Griffiths, UK, Heyderman, RS, Kanyama, C, Kouanfack, C, Mfinanga, S, Chan, AK, Temfack, E, Kivuyo, S, Hosseinipour, MC, Lortholary, O, Loyse, A, Jaffar, S, Harrison, TS, Niessen, LW, ACTA Trial Team

Background\ud Mortality from cryptoccocal meningitis remains high. The ACTA trial demonstrated that, compared with 2 weeks of amphotericin B (AmB) plus flucystosine (5FC), 1 week of AmB and 5FC was associated with lower mortality and 2 weeks of oral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ac8abe6ccc1d99ff9013e3820aedad89
https://openaccess.sgul.ac.uk/id/eprint/110685/6/ciy971.pdf

Long term mortality and disability in Cryptococcal Meningitis: a systematic literature review

Autor: Pasquier, E, Kunda, J, De Beaudrap, P, Loyse, A, Temfack, E, Molloy, SF, Harrison, TS, Lortholary, O

Cryptococcal meningitis (CM) is the primary cause of meningitis in HIV-infected adults and an emerging disease in HIV-seronegative individuals. No literature review has studied the long-term outcome of CM. We performed a systematic review on the long

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7ecdfce54d9a866fdf8a96d86bc0efcd

COVID-19-associated pulmonary aspergillosis in mechanically ventilated patients: a prospective, multicentre UK study.

Autor: Hurt W; Institute of Infection and Immunity, St George's University of London, London, UK whurt@sgul.ac.uk.; Clinical Infection Unit, St George's University Hospitals NHS Foundation Trust, London, UK.; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Youngs J; Institute of Infection and Immunity, St George's University of London, London, UK.; Clinical Infection Unit, St George's University Hospitals NHS Foundation Trust, London, UK., Ball J; Adult Critical Care, St George's University Hospitals NHS Foundation Trust, London, UK., Edgeworth J; Clinical Infection and Microbiology, Guy's and St Thomas' NHS Foundation Trust, London, UK., Hopkins P; Adult Critical Care, King's College Hospital NHS Foundation Trust, London, UK., Jenkins DR; Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, UK., Leaver S; Adult Critical Care, St George's University Hospitals NHS Foundation Trust, London, UK., Mazzella A; Institute of Infection and Immunity, St George's University of London, London, UK., Molloy SF; Institute of Infection and Immunity, St George's University of London, London, UK., Schelenz S; Medical Microbiology, King's College Hospital NHS Foundation Trust, London, UK., Wise MP; Adult Critical Care, University of Wales Hospital, Cardiff, UK., White PL; Microbiology, Public Health Wales, Cardiff, UK., Yusuff H; Adult Critical Care, University Hospitals of Leicester NHS Trust, Leicester, UK., Wyncoll D; Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, London, UK., Bicanic T; Institute of Infection and Immunity, St George's University of London, London, UK.; Clinical Infection Unit, St George's University Hospitals NHS Foundation Trust, London, UK.; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK.

Publikováno v: Thorax [Thorax] 2023 Dec 15; Vol. 79 (1), pp. 75-82. Date of Electronic Publication: 2023 Dec 15.

Reduction in mortality from HIV-related CNS infections in routine care in Africa (DREAMM): a before-and-after, implementation study.

Autor: Mfinanga S; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania; Department of International Public Health, Liverpool School of Tropical Medicine, Liverpool, UK., Kanyama C; University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe, Malawi., Kouanfack C; University of Dschang, Dschang, Cameroon., Nyirenda S; Zomba Central Hospital, Zomba, Malawi., Kivuyo SL; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania., Boyer-Chammard T; Unité de Mycologie Moléculaire, Institut Pasteur, Université de Paris, Centre National de la Recherche Scientifique, Paris, France., Phiri S; Lighthouse Trust, Lilongwe, Malawi., Ngoma J; Kamuzu Central Hospital, Lilongwe, Malawi., Shimwela M; Amana Hospital, Dar es Salaam, Tanzania., Nkungu D; Mwananyamala Hospital, Dar es Salaam, Tanzania., Fomete LN; Yaoundé Central Hospital, Yaoundé, Cameroon., Simbauranga R; National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania., Chawinga C; University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe, Malawi., Ngakam N; Yaoundé Central Hospital, Yaoundé, Cameroon., Heller T; Lighthouse Trust, Lilongwe, Malawi., Lontsi SS; Yaoundé Central Hospital, Yaoundé, Cameroon., Aghakishiyeva E; Institute for Infection and Immunity, St George's University of London, London, UK., Jalava K; Wood Street Veterinary Hospital, Barnet, UK., Fuller S; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Reid AM; Leeds Institute of Medical Education, University of Leeds, Leeds, UK., Rajasingham R; University of Minnesota, Minneapolis, MN, USA., Lawrence DS; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana., Hosseinipour MC; University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe, Malawi., Beaumont E; Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine, London, UK., Bradley J; Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine, London, UK., Jaffar S; UCL Institute for Global Health, University College London, London, UK., Lortholary O; Unité de Mycologie Moléculaire, Institut Pasteur, Université de Paris, Centre National de la Recherche Scientifique, Paris, France; Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris, Institut Hospitalier Universitaire Imagine, Paris, France., Harrison T; Institute for Infection and Immunity, St George's University of London, London, UK., Molloy SF; Institute for Infection and Immunity, St George's University of London, London, UK., Sturny-Leclère A; Institut Pasteur, Université Paris Cité, National Reference Center for Invasive Mycoses and Antifungals, Translational Mycology Research Group, Mycology Department, Paris, France., Loyse A; Unité de Mycologie Moléculaire, Institut Pasteur, Université de Paris, Centre National de la Recherche Scientifique, Paris, France; Institute for Infection and Immunity, St George's University of London, London, UK. Electronic address: aloyse@sgul.ac.uk.

Publikováno v: The lancet. HIV [Lancet HIV] 2023 Oct; Vol. 10 (10), pp. e663-e673.