Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mollie R. Mitchem"'
Autor:
Victoria F. Beja-Glasser, John G. Doench, Amanda Vernon, Myriam Heiman, Alex Powers, Medina Colic, Mudra Hegde, Ruth Kulicke, Mollie R. Mitchem, Lea J. Hachigian, Gurrein K. Madan, Manolis Kellis, Martine Therrien, Fan Gao, Vanessa Lau, Hyeseung Lee, Traver Hart, S. Sebastian Pineda, Mary H. Wertz
Publikováno v:
PMC
Neuron
Neuron
© 2020 Elsevier Inc. Unbiased in vivo genome-wide genetic screening is a powerful approach to elucidate new molecular mechanisms, but such screening has not been possible to perform in the mammalian central nervous system (CNS). Here, we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b1117a2f4ec7899084a89a7693ad87
https://hdl.handle.net/1721.1/136278
https://hdl.handle.net/1721.1/136278
Autor:
Mollie R. Mitchem (7954652)
Caspases are a major contributor to the apoptotic pathway. We intended to investigate the role of caspases, namely caspase-6, which has not been fully characterized in Amyotrophic Lateral Sclerosis (ALS). We utilized quantitative PCR (qPCR) to determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9c1fd6bc5da7b25a121664d21f91fc
Publikováno v:
Neurobiology of Aging. 36:1140-1150
Adenosine 5'-monophosphate-activated protein kinase (AMPK) is a master regulator of energy balance. As energy imbalance is documented as a key pathologic feature of amyotrophic lateral sclerosis (ALS), we investigated AMPK as a pharmacologic target i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf94344e64bf16c84b3aa72a83f875d
https://doi.org/10.1016/j.neurobiolaging.2014.09.022
https://doi.org/10.1016/j.neurobiolaging.2014.09.022
Autor:
Katie Nolan, Caoimhín G. Concannon, Mollie R. Mitchem, Jochen H. M. Prehn, Eva M. Jimenez-Mateos, David C. Henshall
Publikováno v:
Journal of Molecular Neuroscience. 53:231-241
Endoplasmic reticulum (ER) stress has been implicated in a number of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). MicroRNAs are small ribonucleic acids which can modulate protein expression by binding to the 3'UTR of target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a789148616f1436c375ef5512c2d4a6f
https://doi.org/10.1007/s12031-014-0290-y
https://doi.org/10.1007/s12031-014-0290-y
Publikováno v:
Biochimica et biophysica acta. 1862(6)
In amyotrophic lateral sclerosis (ALS), it has been suggested that the process of neurodegeneration starts at the neuromuscular junction and is propagated back along axons towards motor neurons. Caspase-dependent pathways are well established as a ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af35caf78bc0f6dfbb42482d10341533
https://pubmed.ncbi.nlm.nih.gov/26976329
https://pubmed.ncbi.nlm.nih.gov/26976329
Autor:
Karen S. Coughlan, Marion C. Hogg, Ina Woods, Bridget Breen, Mollie R. Mitchem, Á T Behan, Jochen H. M. Prehn
Publikováno v:
Cell death and differentiation. 20(4)
Amyotrophic lateral sclerosis (ALS) is a fatal neurological condition with no cure. Mitochondrial dysfunction, Ca(2+) overloading and local hypoxic/ischemic environments have been implicated in the pathophysiology of ALS and are conditions that may i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eed6f847aaaed043a68ec1885ea9db9
https://pubmed.ncbi.nlm.nih.gov/24185620
https://pubmed.ncbi.nlm.nih.gov/24185620