Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mollie A. Woodworth"'
Autor:
Luciano C. Greig, Mollie B. Woodworth, Alexandros Poulopoulos, Stephanie Lim, Jeffrey D. Macklis
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114650- (2024)
Summary: We describe a binary expression aleatory mosaic (BEAM) system, which relies on DNA delivery by transfection or viral transduction along with nested recombinase activity to generate two genetically distinct, non-overlapping populations of cel
Externí odkaz:
https://doaj.org/article/08a56f9f04354677a248b58729b70d83
Autor:
Alissa M. D’Gama, Mollie B. Woodworth, Amer A. Hossain, Sara Bizzotto, Nicole E. Hatem, Christopher M. LaCoursiere, Imad Najm, Zhong Ying, Edward Yang, A. James Barkovich, David J. Kwiatkowski, Harry V. Vinters, Joseph R. Madsen, Gary W. Mathern, Ingmar Blümcke, Annapurna Poduri, Christopher A. Walsh
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3754-3766 (2017)
Focal cortical dysplasia (FCD) and hemimegalencephaly (HME) are epileptogenic neurodevelopmental malformations caused by mutations in mTOR pathway genes. Deep sequencing of these genes in FCD/HME brain tissue identified an etiology in 27 of 66 cases
Externí odkaz:
https://doaj.org/article/6b8cdd42f6cb4f5e9535741ef54a0e4e
Autor:
Mollie B. Woodworth, Luciano C. Greig, Kevin X. Liu, Gregory C. Ippolito, Haley O. Tucker, Jeffrey D. Macklis
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 999-1012 (2016)
The molecular linkage between neocortical projection neuron subtype and area development, which enables the establishment of functional areas by projection neuron populations appropriate for specific sensory and motor functions, is poorly understood.
Externí odkaz:
https://doaj.org/article/84f04d3eee2147b1a3d811419af0ec39
Autor:
Luciano C. Greig, Mollie B. Woodworth, Alexandros Poulopoulos, Stephanie Lim, Jeffrey D. Macklis
Publikováno v:
bioRxiv
Genetic mosaic analysis, in which mutant cells reside intermingled with wild-type cells, is a powerful experimental approach, but has not been widely used in mice because existing genome-based strategies require complicated and protracted breeding sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75789b1ffd8337d7059eaf3aea743ef1
https://doi.org/10.1101/2023.02.16.528875
https://doi.org/10.1101/2023.02.16.528875
Autor:
Vibhu Sahni, Lincoln Pasquina, Nicole Gonzalez-Nava, Peter Sarnow, Verl B Siththanandan, Victoria Lu, Suzanne Tharin, Theo D. Palmer, Ramesh V. Nair, Jessica L. MacDonald, Abdulkadir Ozkan, Mollie B. Woodworth, Zihuai He, Jessica L Diaz, Jeffrey D. Macklis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The mammalian central nervous system contains unique projections from the cerebral cortex thought to underpin complex motor and cognitive skills, including the corticospinal tract and corpus callosum. The neurons giving rise to these pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d40116cf650b012fae991d550b8bd0
https://doi.org/10.1073/pnas.2006700117
https://doi.org/10.1073/pnas.2006700117
Autor:
Abdulkadir Ozkan, Jeffrey D. Macklis, Peter Sarnow, Lincoln Pasquina, Theo D. Palmer, Zihuai He, Verl B Siththanandan, Jessica L Diaz, Victoria Lu, Vibhu Sahni, Mollie B. Woodworth, Suzanne Tharin, Jessica L. MacDonald, Ramesh V. Nair, Nicole Gonzalez-Nava
The corticospinal tract is unique to mammals and the corpus callosum is unique to placental mammals (eutherians). The emergence of these structures is thought to underpin the evolutionary acquisition of complex motor and cognitive skills. Corticospin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dada319e32bbfc703377a519bc820d74
https://doi.org/10.1101/2020.09.08.286955
https://doi.org/10.1101/2020.09.08.286955
Autor:
Daniel E. Bauer, Donyell M. Croney, Yuko Fujiwara, Luciano C. Greig, Jeffrey D. Macklis, Matthew Nguyen, Mollie B. Woodworth, Elenoe C. Smith, Sidinh Luc, Falak Sher, Stuart H. Orkin
Publikováno v:
Blood. 128:2338-2342
BCL11A, a repressor of human fetal (γ-)globin expression, is required for immune and hematopoietic stem cell functions and brain development. Regulatory sequences within the gene, which are subject to genetic variation affecting fetal globin express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3dc629cd1765a3f625cf2551f05a3d9
https://doi.org/10.1182/blood-2016-08-736249
https://doi.org/10.1182/blood-2016-08-736249
Autor:
Lovelace J. Luquette, Bhaven K. Mehta, Xuyu Cai, Eunjung Lee, Peter J. Park, Thomas Chittenden, Alissa M. D'Gama, Soohyun Lee, Gilad D. Evrony, Mollie B. Woodworth, Amir Karger, Michael A. Lodato, Christopher A. Walsh, Semin Lee
Publikováno v:
Science. 350:94-98
Individualized neuronal mutations in the human brain The neurons of the human brain can last for decades, carrying out computational and signaling functions. Lodato et al. analyzed the DNA of individual neurons sampled from postmortem human brains an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef95fb504eb6c8db511b86d78e31991
https://doi.org/10.1126/science.aab1785
https://doi.org/10.1126/science.aab1785
Autor:
Imad Najm, A. James Barkovich, Nicole E. Hatem, Annapurna Poduri, Mollie B. Woodworth, Zhong Ying, Christopher M. LaCoursiere, Amer A. Hossain, Alissa M. D'Gama, Ingmar Blümcke, Gary W. Mathern, David J. Kwiatkowski, Christopher A. Walsh, Sara Bizzotto, Joseph R. Madsen, Harry V. Vinters, Edward Yang
Publikováno v:
Epilepsy Currents
Cell Reports, Vol 21, Iss 13, Pp 3754-3766 (2017)
Cell reports, vol 21, iss 13
Cell Reports, Vol 21, Iss 13, Pp 3754-3766 (2017)
Cell reports, vol 21, iss 13
Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias D'Gama AM, Woodworth MB, Hossain AA, Bizzotto S, Hatem NE, LaCoursiere CM, Najm I, Ying Z, Yang E, Barkovich AJ, Kwiatkowski DJ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a40c6d1331472742d2cb14c4ea2413
https://europepmc.org/articles/PMC5752134/
https://europepmc.org/articles/PMC5752134/
Autor:
Pengwei Yang, Rachel E. Rodin, Chandri N. Yandava, Michael E. Coulter, Alison R. Barton, Michael A. Lodato, Mollie B. Woodworth, Christopher A. Walsh, Steven C. Ryu, Carl Vitzthum, Craig L. Bohrson, Maxwell A. Sherman, Min-Seok Kwon, Thomas Chittenden, Lovelace J. Luquette, Nicole E. Hatem, Peter J. Park
Brain mutations, young and old Most neurons that make up the human brain are postmitotic, living and functioning for a very long time without renewal (see the Perspective by Lee). Bae et al. examined the genomes of single neurons from the prenatal de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88f1351bab5908694454cc88f48013d