CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.

Autor: Skoulidis F; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. fskoulidis@mdanderson.org., Araujo HA; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Do MT; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Qian Y; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sun X; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cobo AG; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Le JT; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Montesion M; Foundation Medicine, Cambridge, MA, USA., Palmer R; Pionyr Immunotherapeutics, South San Francisco, CA, USA., Jahchan N; Pionyr Immunotherapeutics, South San Francisco, CA, USA., Juan JM; D2G Oncology, Mountain View, CA, USA., Min C; Tango Therapeutics, Boston, MA, USA., Yu Y; Tango Therapeutics, Boston, MA, USA., Pan X; Tango Therapeutics, Boston, MA, USA., Arbour KC; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Vokes N; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Schmidt ST; Department of Genomic Medicine and the Institute for Data Science in Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Molkentine D; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Owen DH; Division of Medical Oncology, Ohio State University-James Comprehensive Cancer Center, Columbus, OH, USA., Memmott R; Division of Medical Oncology, Ohio State University-James Comprehensive Cancer Center, Columbus, OH, USA., Patil PD; Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA., Marmarelis ME; Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Awad MM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Murray JC; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hellyer JA; Department of Genetics, Stanford University, Stanford, CA, USA., Gainor JF; Massachussetts General Hospital, Boston, MA, USA., Dimou A; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Bestvina CM; Department of Medicine, University of Chicago, Chicago, IL, USA., Shu CA; Columbia University, New York, NY, USA., Riess JW; University of California Davis Comprehensive Cancer Center, Sacramento, CA, USA., Blakely CM; University of California San Francisco, San Francisco, CA, USA., Pecot CV; UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA., Mezquita L; Department of Medical Oncology, Hospital Clinic de Barcelona, Barcelona, Spain., Tabbó F; Ospedale Michele e Pietro Ferrero, Cuneo, Italy., Scheffler M; Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany., Digumarthy S; Department of Radiology, Massachussetts General Hospital, Boston, MA, USA., Mooradian MJ; Massachussetts General Hospital, Boston, MA, USA., Sacher AG; Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Lau SCM; Department of Medical Oncology, NYU Langone Perlmutter Cancer Center, New York, NY, USA., Saltos AN; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA., Rotow J; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Johnson RP; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Liu C; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Stewart T; Division of Hematology-Oncology, University of California San Diego, La Jolla, CA, USA., Goldberg SB; Yale School of Medicine, New Haven, CT, USA., Killam J; North Shore University Hospital, Manhasset, NY, USA., Walther Z; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Schalper K; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Davies KD; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Woodcock MG; UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA., Anagnostou V; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Marrone KA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Forde PM; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Venkatraman D; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Van Allen EM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Cummings AL; David Geffen School of Medicine at the University of California, Los Angeles, CA, USA., Goldman JW; David Geffen School of Medicine at the University of California, Los Angeles, CA, USA., Shaish H; Columbia University, New York, NY, USA., Kier M; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Katz S; Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Aggarwal C; Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Ni Y; Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA., Azok JT; Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA., Segal J; Department of Pathology, University of Chicago, Chicago, USA., Ritterhouse L; Foundation Medicine, Cambridge, MA, USA., Neal JW; Department of Genetics, Stanford University, Stanford, CA, USA., Lacroix L; Institut Gustave Roussy, Villejuif, France., Elamin YY; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Negrao MV; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Le X; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lam VK; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lewis WE; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kemp HN; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Carter B; Department of Thoracic Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Roth JA; Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Swisher S; Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lee R; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhou T; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Poteete A; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kong Y; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Takehara T; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Paula AG; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Parra Cuentas ER; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Behrens C; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wistuba II; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhang J; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Blumenschein GR; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gay C; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Byers LA; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gibbons DL; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tsao A; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lee JJ; Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bivona TG; University of California San Francisco, San Francisco, CA, USA., Camidge DR; University of Colorado Cancer Center, Denver, CO, USA., Gray JE; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA., Lieghl N; Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Levy B; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Brahmer JR; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Garassino MC; Department of Medicine, University of Chicago, Chicago, IL, USA., Gandara DR; University of California Davis Comprehensive Cancer Center, Sacramento, CA, USA., Garon EB; David Geffen School of Medicine at the University of California, Los Angeles, CA, USA., Rizvi NA; Synthekine, Menlo Park, CA, USA., Scagliotti GV; University of Turin, Orbassano, Italy., Wolf J; Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany., Planchard D; Institut Gustave Roussy, Villejuif, France., Besse B; Institut Gustave Roussy, Villejuif, France., Herbst RS; Yale School of Medicine, New Haven, CT, USA., Wakelee HA; Department of Genetics, Stanford University, Stanford, CA, USA., Pennell NA; Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA., Shaw AT; Novartis Institute for Biomedical Research, Cambridge, MA, USA., Jänne PA; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Carbone DP; Division of Medical Oncology, Ohio State University-James Comprehensive Cancer Center, Columbus, OH, USA., Hellmann MD; AstraZeneca, Gaithersburg, MD, USA., Rudin CM; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Albacker L; Foundation Medicine, Cambridge, MA, USA., Mann H; AstraZeneca, Cambridge, UK., Zhu Z; AstraZeneca, Cambridge, UK., Lai Z; AstraZeneca, Cambridge, UK., Stewart R; AstraZeneca, Cambridge, UK., Peters S; Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland., Johnson ML; Sarah Cannon Research Institute, Tennessee Oncology, Nashville, TN, USA., Wong KK; Division of Hematology & Medical Oncology, NYU Langone Perlmutter Cancer Center, New York, NY, USA., Huang A; Tango Therapeutics, Boston, MA, USA., Winslow MM; D2G Oncology, Mountain View, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA., Rosen MJ; D2G Oncology, Mountain View, CA, USA., Winters IP; D2G Oncology, Mountain View, CA, USA., Papadimitrakopoulou VA; Pfizer, New York, NY, USA., Cascone T; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jewsbury P; AstraZeneca, Cambridge, UK., Heymach JV; Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. jheymach@mdanderson.org.

Publikováno v: Nature [Nature] 2024 Nov; Vol. 635 (8038), pp. 462-471. Date of Electronic Publication: 2024 Oct 09.

FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner.

Autor: Pifer PM; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Yang L; Department of Experimental Radiation Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas., Kumar M; Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bilaspur, Himachal Pradesh, India., Xie T; Department of Head and Neck Surgery, University of Texas, MD Anderson Cancer Center, Houston, Texas., Frederick M; Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas., Hefner A; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Beadle B; Department of Radiation Oncology, Stanford University, Stanford, California., Molkentine D; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Molkentine J; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Dhawan A; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Abdelhakiem M; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Osman AA; Department of Head and Neck Surgery, University of Texas, MD Anderson Cancer Center, Houston, Texas., Leibowitz BJ; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Myers JN; Department of Head and Neck Surgery, University of Texas, MD Anderson Cancer Center, Houston, Texas., Pickering CR; Department of Head and Neck Surgery, University of Texas, MD Anderson Cancer Center, Houston, Texas., Sandulache VC; Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas., Heymach J; Department of Thoracic and Head and Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas., Skinner HD; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Jan 05; Vol. 30 (1), pp. 187-197.

MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma.

Autor: Qian Y; Department of Thoracic/Head and Neck Medical Oncology, Houston, TX, USA., Galan-Cobo A; Department of Thoracic/Head and Neck Medical Oncology, Houston, TX, USA., Guijarro I; Department of Thoracic/Head and Neck Medical Oncology, Houston, TX, USA., Dang M; Department of Genomic Medicine, Houston, TX, USA., Molkentine D; Department of Thoracic/Head and Neck Medical Oncology, Houston, TX, USA., Poteete A; Department of Thoracic/Head and Neck Medical Oncology, Houston, TX, USA., Zhang F; Department of Thoracic/Head and Neck Medical Oncology, Houston, TX, USA., Wang Q; Department of Bioinformatics and Computational Biology, Houston, TX, USA., Wang J; Department of Bioinformatics and Computational Biology, Houston, TX, USA., Parra E; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Panda A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fang J; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Skoulidis F; Department of Thoracic/Head and Neck Medical Oncology, Houston, TX, USA., Wistuba II; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Verma S; Ludwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA., Merghoub T; Ludwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA., Wolchok JD; Ludwig Collaborative and Swim Across America Laboratory, MSK, New York, NY, USA., Wong KK; Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA., DeBerardinis RJ; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Minna JD; Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA., Vokes NI; Department of Thoracic/Head and Neck Medical Oncology, Houston, TX, USA., Meador CB; Department of Medicine, Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA; Center for Thoracic Cancers, Massachusetts General Hospital, Boston, MA, USA., Gainor JF; Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Center for Thoracic Cancers, Massachusetts General Hospital, Boston, MA, USA., Wang L; Department of Genomic Medicine, Houston, TX, USA., Reuben A; Department of Thoracic/Head and Neck Medical Oncology, Houston, TX, USA., Heymach JV; Department of Thoracic/Head and Neck Medical Oncology, Houston, TX, USA. Electronic address: jheymach@mdanderson.org.

Publikováno v: Cancer cell [Cancer Cell] 2023 Jul 10; Vol. 41 (7), pp. 1363-1380.e7. Date of Electronic Publication: 2023 Jun 15.

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.

Autor: Kumar M; Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bilaspur, Himachal Pradesh, India., Molkentine D; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Molkentine J; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Bridges K; Department of Experimental Radiation Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA., Xie T; Department of Head and Neck Surgery, University of Texas, MD Anderson Cancer Center, Houston, TX, USA., Yang L; Department of Experimental Radiation Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA., Hefner A; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Gao M; Department of Head and Neck Surgery, University of Texas, MD Anderson Cancer Center, Houston, TX, USA., Bahri R; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Dhawan A; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Frederick MJ; Department of Otolaryngology-Head & Neck Surgery, Baylor College of Medicine, Houston, TX, USA., Seth S; TRACTION Platform, University of Texas, MD Anderson Cancer Center, Houston, TX, USA., Abdelhakiem M; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Beadle BM; Department of Radiation Oncology, Stanford University, Stanford, CA, USA., Johnson F; Department of Thoracic and Head and Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA., Wang J; The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA.; Department of Biostatistics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA., Shen L; Department of Biostatistics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA., Heffernan T; TRACTION Platform, University of Texas, MD Anderson Cancer Center, Houston, TX, USA., Sheth A; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Ferris RL; Department of Otolaryngology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Myers JN; Department of Head and Neck Surgery, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA., Pickering CR; Department of Head and Neck Surgery, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA., Skinner HD; Department of Radiation Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. skinnerh@upmc.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Nov 03; Vol. 12 (1), pp. 6340. Date of Electronic Publication: 2021 Nov 03.

CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC.

Autor: Zhang, Shuzhen^1,2 (AUTHOR), Wang, Jingjing¹ (AUTHOR), Chen, Yang^1,3 (AUTHOR), Liang, Weilian^1,4 (AUTHOR), Liu, Hanzhe¹ (AUTHOR), Du, Ruixue¹ (AUTHOR), Sun, Yunqing¹ (AUTHOR), Hu, Chuanyu^5,6,7 (AUTHOR) chuanyuhu@hust.edu.cn, Shang, Zhengjun^1,8 (AUTHOR) shangzhengjun@whu.edu.cn

Publikováno v: Cell & Bioscience. 11/27/2024, Vol. 14 Issue 1, p1-14. 14p.