Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH

Autor: Tim Schulte, Marc D. Panas, Xiao Han, Lucy Williams, Nancy Kedersha, Jonas Simon Fleck, Timothy J. C. Tan, Xaquin Castro Dopico, Anders Olsson, Ainhoa Moliner Morro, Leo Hanke, Johan Nilvebrant, Kim Anh Giang, Per-Åke Nygren, Paul Anderson, Adnane Achour, Gerald M. McInerney

Publikováno v: Open Biology, Vol 13, Iss 5 (2023)

G3BP is the central node within stress-induced protein–RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formati

Externí odkaz: https://doaj.org/article/719e066a65f94ead97a58a120d59ffcd

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

Autor: Thomas Kruse, Caroline Benz, Dimitriya H. Garvanska, Richard Lindqvist, Filip Mihalic, Fabian Coscia, Raviteja Inturi, Ahmed Sayadi, Leandro Simonetti, Emma Nilsson, Muhammad Ali, Johanna Kliche, Ainhoa Moliner Morro, Andreas Mund, Eva Andersson, Gerald McInerney, Matthias Mann, Per Jemth, Norman E. Davey, Anna K. Överby, Jakob Nilsson, Ylva Ivarsson

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Many interactions between viral and host proteins are mediated by short peptide motifs. Here, using a phage-based viral peptide library, the authors identify 269 peptide-based interactions for 18 coronaviruses, including an interaction between SARS-C

Externí odkaz: https://doaj.org/article/1f444706eff944aca145f8ed28412f90

Author response for 'Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH'

Autor: null Tim Schulte, null Marc D. Panas, null Xiao Han, null Lucy Williams, null Nancy Kedersha, null Jonas Simon Fleck, null Timothy J. C. Tan, null Xaquin Castro Dopico, null Anders Olsson, null Ainhoa Moliner Morro, null Leo Hanke, null Johan Nilvebrant, null Kim Anh Giang, null Per-Åke Nygren, null Paul Anderson, null Adnane Achour, null Gerald M. McInerney

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f406bebec2fbab5f7e9a3dbba5cb3d3
https://doi.org/10.1098/rsob.220369/v2/response1

Protection against SARS-CoV-2 transmission by a parenteral prime—Intranasal boost vaccine strategy

Autor: Dennis Christensen, Charlotta Polacek, Daniel J. Sheward, Leo Hanke, Ainhoa Moliner-Morro, Gerald McInerney, Ben Murrell, Katrine Top Hartmann, Henrik Elvang Jensen, Gregers Jungersen, Kristin Illigen, Louise Krag Isling, Rune Fledelius Jensen, Julia Sid Hansen, Ida Rosenkrands, Carlota Fernandez-Antunez, Santseharay Ramirez, Frank Follmann, Jens Bukh, Gabriel Kristian Pedersen

Publikováno v: Christensen, D, Polacek, C, Sheward, D J, Hanke, L, Moliner-morro, A, Mcinerney, G, Murrell, B, Hartmann, K T, Jensen, H E, Jungersen, G, Illigen, K, Isling, L K, Jensen, R F, Hansen, J S, Rosenkrands, I, Fernandez-antunez, C, Ramirez, S, Follmann, F, Bukh, J & Pedersen, G K 2022, ' Protection against SARS-CoV-2 transmission by a parenteral prime—Intranasal boost vaccine strategy ', EBioMedicine, vol. 84, 104248 . https://doi.org/10.1016/j.ebiom.2022.104248

BackgroundLicensed vaccines against SARS-CoV-2 effectively protect against severe disease, but display incomplete protection against virus transmission. Mucosal vaccines providing immune responses in the upper airways are one strategy to protect agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2478ec4aa0e62dda8ed072c9896cfd5e
https://curis.ku.dk/portal/da/publications/protection-against-sarscov2-transmission-by-a-parenteral-primeintranasal-boost-vaccine-strategy(a89bca21-8a1d-4c31-b509-47e01826cdbd).html

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus

Autor: Margit Mutso, Ainhoa Moliner Morro, Cecilia Smedberg, Sergo Kasvandik, Muriel Aquilimeba, Mona Teppor, Liisi Tarve, Aleksei Lulla, Valeria Lulla, Sirle Saul, Bastian Thaa, Gerald M McInerney, Andres Merits, Margus Varjak

Publikováno v: Viruses, Vol 10, Iss 5, p 226 (2018)

Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus

Externí odkaz: https://doaj.org/article/436e6e42498f4d28a75d5d8db1b0d5fb