Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death

Autor: Thornberry, N. A., Molineaux, S. M.

Interleukin-1 beta converting enzyme is the first member of a new class of cysteine proteases. The most distinguishing feature of this family is a nearly absolute specificity for cleavage at aspartic acid. This enzyme has been the subject of intense

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https://europepmc.org/articles/PMC2142972/

Recombination within the myelin basic protein gene created the dysmyelinating shiverer mouse mutation.

Autor: Molineaux, S M, Engh, H, de Ferra, F, Hudson, L, Lazzarini, R A

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; October 1986, Vol. 83 Issue: 19 p7542-7546, 5p

Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme.

Autor: Molineaux, S M, Casano, F J, Rolando, A M, Peterson, E P, Limjuco, G, Chin, J, Griffin, P R, Calaycay, J R, Ding, G J, Yamin, T T

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; March 1993, Vol. 90 Issue: 5 p1809-1813, 5p

Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.

Autor: Munday, N A, Vaillancourt, J P, Ali, A, Casano, F J, Miller, D K, Molineaux, S M, Yamin, T T, Yu, V L, Nicholson, D W

Publikováno v: Journal of Biological Chemistry; June 1995, Vol. 270 Issue: 26 p15870-6, 7p

Molecular and structural insights into the 5-HT 2C receptor as a therapeutic target for substance use disorders.

Autor: Ubhayarathna M; Drug Discovery Biology and Neuroscience & Mental Health Therapeutic Program Area, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Langmead CJ; Drug Discovery Biology and Neuroscience & Mental Health Therapeutic Program Area, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.; Neuromedicines Discovery Centre, Monash University, Parkville, Australia., Diepenhorst NA; Drug Discovery Biology and Neuroscience & Mental Health Therapeutic Program Area, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Stewart GD; Drug Discovery Biology and Neuroscience & Mental Health Therapeutic Program Area, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.; Neuromedicines Discovery Centre, Monash University, Parkville, Australia.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Nov; Vol. 181 (22), pp. 4414-4429. Date of Electronic Publication: 2023 Oct 02.