Enhanced Vasoconstriction in Sickle Cell Disease is Dependent on ETA Receptor Activation.

Autor: Allan JM; The University of Alabama at Birmingham, Birmingham, Alabama, United States., Fox BM; The University of Alabama at Birmingham, Birmingham, Alabama, United States., Kasztan M; The University of Alabama at Birmingham., Kelly GC; The University of Alabama at Birmingham, Birmingham, Alabama, United States., Molina PA; The University of Alabama at Birmingham, Birmingham, Alabama, United States., King MA; The University of Alabama at Birmingham, Birmingham, Alabama, United States., Colson J; The University of Alabama at Birmingham, Birmingham, Alabama, United States., Wells L; Augusta University Medical College of Georgia, Augusta, Georgia, United States., Bowman L; Augusta University Medical College of Georgia, Augusta, Georgia, United States., Blackburn M; Augusta University Medical College of Georgia, Augusta, Georgia, United States., Kutlar A; Augusta University Medical College of Georgia, Augusta, Georgia, United States., Harris RA; Augusta University, Augusta, Georgia, United States., Pollock DM; University of Alabama at Birmingham, Birmingham, Alabama, United States., Pollock J; The University of Alabama at Birmingham, Birmingham, Alabama, United States.

Publikováno v: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2024 Nov 11. Date of Electronic Publication: 2024 Nov 11.

Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high-salt diet.

Autor: Dunaway LS; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Cook AK; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Kellum CE; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Edell C; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Botta D; Department of Microbiology, Heersink School of Medicine, Immunology Institute, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Molina PA; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Sedaka RS; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., d'Uscio LV; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA., Katusic ZS; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA., Pollock DM; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Inscho EW; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Pollock JS; Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

Publikováno v: Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2024 Sep; Vol. 240 (9), pp. e14201. Date of Electronic Publication: 2024 Jul 15.

Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide.

Autor: Li X; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China. xiaolong@crystal.harvard.edu.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA. xiaolong@crystal.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA. xiaolong@crystal.harvard.edu., Singh NK; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, 02142, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA., Collins DR; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA., Ng R; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA., Zhang A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA., Lamothe-Molina PA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA., Shahinian P; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA., Xu S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA., Tan K; Structural Biology Center, X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Lemont, IL, 60439, USA., Piechocka-Trocha A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA., Urbach JM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA., Weber JK; IBM Thomas J. Watson Research Center, Computational Biology Center, Yorktown Heights, NY, 10598, USA., Gaiha GD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, 02114, USA., Takou Mbah OC; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA., Huynh T; IBM Thomas J. Watson Research Center, Computational Biology Center, Yorktown Heights, NY, 10598, USA., Cheever S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA., Chen J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA., Birnbaum M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, 02142, USA., Zhou R; IBM Thomas J. Watson Research Center, Computational Biology Center, Yorktown Heights, NY, 10598, USA.; Department of Chemistry, Columbia University, New York, NY, 10025, USA.; Institute of Quantitative Biology, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China., Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA. bwalker@mgh.harvard.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA. bwalker@mgh.harvard.edu.; Institute for Medical Engineering and Science and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. bwalker@mgh.harvard.edu., Wang JH; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA. jwang@crystal.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02215, USA. jwang@crystal.harvard.edu.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02215, USA. jwang@crystal.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2023 May 22; Vol. 14 (1), pp. 2929. Date of Electronic Publication: 2023 May 22.

Hedgehog blockade remodels the gut microbiota and the intestinal effector CD8 ⁺ T cells in a mouse model of mammary carcinoma.

Autor: Hinshaw DC; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Swain CA; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Chen D; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.; Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Center for Clinical and Translational Sciences, University of Alabama at Birmingham, Birmingham, AL, USA., Hanna A; Vanderbilt Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, TN, USA., Molina PA; Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA., Maynard CL; Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA., Lee G; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., McFarland BC; Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA., Samant RS; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.; Birmingham VA Medical Center, Birmingham, AL, USA., Shevde LA; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. lsamant@uab.edu.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA. lsamant@uab.edu.

Publikováno v: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2022 Nov; Vol. 102 (11), pp. 1236-1244. Date of Electronic Publication: 2022 Jul 30.

Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice.

Autor: Taylor CM; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Kasztan M; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Sedaka R; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Molina PA; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Dunaway LS; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Pollock JS; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Pollock DM; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2021 May 01; Vol. 320 (5), pp. R630-R640. Date of Electronic Publication: 2021 Feb 24.