Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Molee Chakraborty"'
Autor:
Sandip Mukherjee, Molee Chakraborty, Eliwaza N. Msengi, Jake Haubner, Jinsong Zhang, Matthew J. Jellinek, Haley L. Carlson, Kelly Pyles, Barbara Ulmasov, Andrew J. Lutkewitte, Danielle Carpenter, Kyle S. McCommis, David A. Ford, Brian N. Finck, Brent A. Neuschwander-Tetri, Anutosh Chakraborty
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101767- (2023)
Objective: Defining the regulators of cell metabolism and signaling is essential to design new therapeutic strategies in obesity and NAFLD/NASH. E3 ubiquitin ligases control diverse cellular functions by ubiquitination-mediated regulation of protein
Externí odkaz:
https://doaj.org/article/b2642d46704a4c24822cb884661aab61
Autor:
Sandip Mukherjee, Molee Chakraborty, Jake Haubner, Glen Ernst, Michael DePasquale, Danielle Carpenter, James C. Barrow, Anutosh Chakraborty
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 868 (2023)
Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus, drugs for the long-term treatment of these diseases are urgently needed. We previously discovered that the inositol pyrophosphate biosynthetic enzyme IP6K1 is
Externí odkaz:
https://doaj.org/article/2695fa91a3a24772ab51b42c8d89cc7f
Autor:
Sandip Mukherjee, Molee Chakraborty, Barbara Ulmasov, Kyle McCommis, Jinsong Zhang, Danielle Carpenter, Eliwaza Naomi Msengi, Jake Haubner, Chun Guo, Daniel P. Pike, Sarbani Ghoshal, David A. Ford, Brent A. Neuschwander-Tetri, Anutosh Chakraborty
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101364- (2021)
Objective: Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). We have previously discovered that whole-body and adipocyte-specific Ip6k1deletion protects mice from high-fat-d
Externí odkaz:
https://doaj.org/article/fd13f5e8e9714681819f553c2658c06f
Publikováno v:
eLife, Vol 6 (2017)
Current thought envisions dopamine neurons conveying the reinforcing effect of the unconditioned stimulus during associative learning to the axons of Drosophila mushroom body Kenyon cells for normal olfactory learning. Here, we show using functional
Externí odkaz:
https://doaj.org/article/cf9bf2f06e81434ea413b11156bf5180
Autor:
Yubai Zhou, Sandip Mukherjee, Daowei Huang, Molee Chakraborty, Chunfang Gu, Guangning Zong, Michael A. Stashko, Kenneth H. Pearce, Stephen B. Shears, Anutosh Chakraborty, Huanchen Wang, Xiaodong Wang
Publikováno v:
J Med Chem
Obesity and obesity-induced metabolic dysfunctions are significant risk factors for nonalcoholic fatty liver disease and cardiovascular diseases. Thus, obesity is an economic and social burden in developed countries. Blocking the synthesis of inosito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd18436005877b78c4cc91e737f70a50
https://doi.org/10.1021/acs.jmedchem.2c00220
https://doi.org/10.1021/acs.jmedchem.2c00220
Autor:
Sarbani, Ghoshal, Sandip, Mukherjee, Molee, Chakraborty, Eliwaza Naomi, Msengi, Jake, Haubner, Anutosh, Chakraborty
Publikováno v:
International journal of molecular sciences. 23(4)
(1) Background: We previously demonstrated that disruption of IP6K1 improves metabolism, protecting mice from high-fat diet-induced obesity, insulin resistance, and non-alcoholic fatty liver disease and steatohepatitis. Age-induced metabolic dysfunct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4783be4a16590a6fc353b4fa4668435
https://pubmed.ncbi.nlm.nih.gov/35216174
https://pubmed.ncbi.nlm.nih.gov/35216174
Autor:
Sarbani Ghoshal, Sandip Mukherjee, Molee Chakraborty, Eliwaza Naomi Msengi, Jake Haubner, Anutosh Chakraborty
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 4; Pages: 2059
(1) Background: We previously demonstrated that disruption of IP6K1 improves metabolism, protecting mice from high-fat diet-induced obesity, insulin resistance, and non-alcoholic fatty liver disease and steatohepatitis. Age-induced metabolic dysfunct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53447a75db5e185a4ca4dc20d318ae0
https://doi.org/10.3390/ijms23042059
https://doi.org/10.3390/ijms23042059
Autor:
Brent A. Neuschwander-Tetri, Chun Guo, Sandip Mukherjee, Sarbani Ghoshal, Molee Chakraborty, Kyle S. McCommis, Danielle Carpenter, Eliwaza Naomi Msengi, Jinsong Zhang, Barbara Ulmasov, Anutosh Chakraborty, Jake Haubner, Daniel P. Pike, David A. Ford
Publikováno v:
Molecular Metabolism, Vol 54, Iss, Pp 101364-(2021)
Molecular Metabolism
Molecular Metabolism
Objective Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). We have previously discovered that whole-body and adipocyte-specific Ip6k1deletion protects mice from high-fat-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5459d7b9c8fa37cbcb1dc512eeed212
https://doi.org/10.1016/j.molmet.2021.101364
https://doi.org/10.1016/j.molmet.2021.101364
Autor:
Chunfang Gu, Michael A. Stashko, Ana C. Puhl-Rubio, Molee Chakraborty, Anutosh Chakraborty, Stephen V. Frye, Kenneth H. Pearce, Xiaodong Wang, Stephen B. Shears, Huanchen Wang
Dietary flavonoids inhibit certain protein kinases and phospholipid kinases by competing for their ATP-binding sites. These nucleotide pockets have structural elements that are well-conserved in two human small-molecule kinases, inositol hexakisphosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e206762ca992dbbb8e19c4cf8a526e68
https://europepmc.org/articles/PMC6467728/
https://europepmc.org/articles/PMC6467728/
Publikováno v:
Neuron. 90:1230-1242
Summary Forgetting, one part of the brain's memory management system, provides balance to the encoding and consolidation of new information by removing unused or unwanted memories or by suppressing their expression. Recent studies identified the smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484aef0a31ec6fa8b8874f4133781e74
https://doi.org/10.1016/j.neuron.2016.05.010
https://doi.org/10.1016/j.neuron.2016.05.010