Zobrazeno 1 - 10
of 377
pro vyhledávání: '"Molecule docking"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2669-2679 (2024)
HIV-1 can rapidly infect the brain upon initial infection, establishing latent reservoirs that induce neuronal damage and/or death, resulting in HIV-Associated Neurocognitive Disorder. Though anti-HIV-1 antiretrovirals (ARVs) suppress viral load, the
Externí odkaz:
https://doaj.org/article/16081dd8318742cfaf5225af558840bb
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2606-2614 (2024)
Cathepsin L (CTSL) is a promising therapeutic target for metabolic disorders. Current pharmacological interventions targeting CTSL have demonstrated potential in reducing body weight gain, serum insulin levels, and improving glucose tolerance. Howeve
Externí odkaz:
https://doaj.org/article/da7039a22cfa4c6bbf060a08010e244f
Autor:
Yaochen Xie, Shuchen Gong, Lingkun Wang, Zhaoxu Yang, Chen Yang, Guilin Li, Huiyan Zha, Shuying Lv, Boneng Xiao, Xiaoyu Chen, Zhenning Di, Qiaojun He, Jincheng Wang, Qinjie Weng
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Huanglian Jiedu Decoction (HJD) is a well-known Traditional Chinese Medicine formula that has been used for liver protection in thousands of years. However, the therapeutic effects and mechanisms of HJD in treating drug-induced liver injury
Externí odkaz:
https://doaj.org/article/fa17aa93cd094d6cba38a90d40d52a55
Publikováno v:
Food Chemistry: X, Vol 23, Iss , Pp 101649- (2024)
This study investigated the effect of anaerobic treatment on the non-volatile components and angiotensin-converting enzyme (ACE) inhibitory activity in purple-colored leaf tea. Results showed that after 8 h of anaerobic treatment, the γ-aminobutyric
Externí odkaz:
https://doaj.org/article/b8ace10b85ac47fe929619a0da17c00a
Autor:
Ali Mahmood Taher, Hussein Ali Kadhim Kyhoiesh, Azal Shakir Waheeb, Khalid J. Al-Adilee, Layth S. Jasim
Publikováno v:
Results in Chemistry, Vol 12, Iss , Pp 101911- (2024)
The ligand 2-[2′-(benzimidazole)azo]-4,6-dimethyl benzoic acid (BADMB) was employed to create coordination complexes with Pd(II), Co(III), and Pt(IV) ions. A variety of analytical methods were utilized to verify the structures of the synthesized ch
Externí odkaz:
https://doaj.org/article/27d14b38e1c64283849660c1ce8430f4
Publikováno v:
Chimica Techno Acta, Vol 11, Iss 3 (2024)
Coumarin derivatives were synthesized herein from 3-acetyl coumarin and 4-(pyrimidin-2-yldiazenyl) antipyrine, leading to the azo chalcone intermediate compound. The final spiro-heterocyclic coumarins were produced through the cyclization of the azo-
Externí odkaz:
https://doaj.org/article/2c364ab7e9504fbdbe9f867a71703c66
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
ObjectiveBiological studies have elucidated that phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway in humans that is abnormally expressed in numerous cancers. Inhibition of the PHGDH activity is though
Externí odkaz:
https://doaj.org/article/f0ebabd0fb9c407c804bb64209dc4023
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e31861- (2024)
Exserolides are isocoumarin derivatives containing lactone moiety. Recently, some isocoumarins have been demonstrated to ameliorate hyperlipidemia, a major factor for inducing cardiovascular diseases. However, the effects and mechanisms of action of
Externí odkaz:
https://doaj.org/article/a99373aa476242808a018fe8b5107c79
Publikováno v:
Viruses, Vol 16, Iss 8, p 1229 (2024)
The objective of this study was to elucidate the mechanism of action of the active components of Coptidis rhizoma against porcine epidemic diarrhea and to provide a theoretical foundation for further development of novel anti-PED therapeutic agents b
Externí odkaz:
https://doaj.org/article/fe0998350c9d44628c2f033c0f10567f
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Dihydropteridone derivatives represent a novel class of PLK1 inhibitors, exhibiting promising anticancer activity and potential as chemotherapeutic drugs for glioblastoma.Objective: The aim of this study is to develop 2D and 3D-QSAR model
Externí odkaz:
https://doaj.org/article/b3c0365993ef49e38d49c8fd9feff505