Zobrazeno 1 - 10
of 470
pro vyhledávání: '"Molecular pathological epidemiology"'
Autor:
Shibabrata Pattanayak
Publikováno v:
Exploratory Animal and Medical Research, Vol 14, Iss 1, Pp 1-5 (2024)
The biological age of an individual depends mainly on the genetic status and different epigenetic influences experienced by the individual and it has a direct relationship with aging and suffering from different diseases. It can be understood from th
Externí odkaz:
https://doaj.org/article/b5be75aab368423c9dcf3704936faac9
Autor:
Tomotaka Ugai, Takashi Shimizu, Hidetaka Kawamura, Satoko Ugai, Yasutoshi Takashima, Genki Usui, Juha P Väyrynen, Kazuo Okadome, Koichiro Haruki, Naohiko Akimoto, Yohei Masugi, Annacarolina daSilva, Kosuke Mima, Xuehong Zhang, Andrew T Chan, Molin Wang, Wendy S Garrett, Gordon J Freeman, Jeffrey A Meyerhardt, Jonathan A Nowak, Mingyang Song, Marios Giannakis, Shuji Ogino
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 8, Pp n/a-n/a (2023)
Abstract Objectives The CD274 (programmed cell death 1 ligand 1, PD‐L1)/PDCD1 (programmed cell death 1, PD‐1) immune checkpoint axis is known to regulate the antitumor immune response. Evidence also supports an immunosuppressive effect of Fusobac
Externí odkaz:
https://doaj.org/article/6d5f4ff4a6054b57bc63ecd44396a8c0
Autor:
Fenglei Wang, Tomotaka Ugai, Koichiro Haruki, Yi Wan, Naohiko Akimoto, Kota Arima, Rong Zhong, Tyler S. Twombly, Kana Wu, Kanhua Yin, Andrew T. Chan, Marios Giannakis, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Liming Liang, Mingyang Song, Stephanie A. Smith‐Warner, Xuehong Zhang, Edward L. Giovannucci, Walter C. Willett, Shuji Ogino
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 8, Pp n/a-n/a (2022)
Abstract Background Plant‐based foods have been recommended for health. However, not all plant foods are healthy, and little is known about the association between plant‐based diets and specific molecular subtypes of colorectal cancer (CRC). We e
Externí odkaz:
https://doaj.org/article/1e68e56b17664a5ebe70e99610296bb5
Autor:
Naohiko Akimoto, Juha P. Väyrynen, Melissa Zhao, Tomotaka Ugai, Kenji Fujiyoshi, Jennifer Borowsky, Rong Zhong, Koichiro Haruki, Kota Arima, Mai Chan Lau, Junko Kishikawa, Tyler S. Twombly, Yasutoshi Takashima, Mingyang Song, Xuehong Zhang, Kana Wu, Andrew T. Chan, Jeffrey A. Meyerhardt, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThe relationships between tumor stromal features (such as desmoplastic reaction, myxoid stroma, and keloid-like collagen bundles) and immune cells in the colorectal carcinoma microenvironment have not yet been fully characterized.MethodsIn
Externí odkaz:
https://doaj.org/article/d20c46f0ff264504a3db9b0c636524b9
Akademický článek
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Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Aim: To evaluate the effect of Selenium-enriched Lactobacillus acidophilus (Se-enriched L. acidophilus) on dextran sulfate sodium (DSS)-induced colitis in mice.Methods: Mice were randomly divided into four groups: a control group, a control + Se-enri
Externí odkaz:
https://doaj.org/article/c7c74ceb1df245d8a12414b2d1281a4c
Autor:
Tomotaka Ugai, Melissa Zhao, Takashi Shimizu, Naohiko Akimoto, Shanshan Shi, Yasutoshi Takashima, Rong Zhong, Mai Chan Lau, Koichiro Haruki, Kota Arima, Kenji Fujiyoshi, Benjamin Langworthy, Yohei Masugi, Annacarolina da Silva, Katsuhiko Nosho, Yoshifumi Baba, Mingyang Song, Andrew T. Chan, Molin Wang, Jeffrey A. Meyerhardt, Marios Giannakis, Juha P. Väyrynen, Jonathan A. Nowak, Shuji Ogino
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Immunotherapy targeting the CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint axis has emerged as a promising treatment strategy for various cancers. Experimental evidence suggests that phosphatidylinositol-4,5-bisphosphonate 3-kinase (PI3K) signaling may
Externí odkaz:
https://doaj.org/article/8315443e3399426abca4162e65e060a8
Akademický článek
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Autor:
Kenji Fujiyoshi, Juha P. Väyrynen, Jennifer Borowsky, David J. Papke, Jr., Kota Arima, Koichiro Haruki, Junko Kishikawa, Naohiko Akimoto, Tomotaka Ugai, Mai Chan Lau, Simeng Gu, Shanshan Shi, Melissa Zhao, Annacarolina Fabiana Lucia Da Silva, Tyler S. Twombly, Hongmei Nan, Jeffrey A. Meyerhardt, Mingyang Song, Xuehong Zhang, Kana Wu, Andrew T. Chan, Charles S. Fuchs, Jochen K. Lennerz, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Publikováno v:
EBioMedicine, Vol 57, Iss , Pp 102860- (2020)
Background: Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and PDC in colo
Externí odkaz:
https://doaj.org/article/36f00dc68e4c4aca9c93d5fc3721bf2b
Autor:
Tsuyoshi Hamada, Thing Rinda Soong, Yohei Masugi, Keisuke Kosumi, Jonathan A. Nowak, Annacarolina da Silva, Xinmeng Jasmine Mu, Tyler S. Twombly, Hideo Koh, Juhong Yang, Mingyang Song, Li Liu, Mancang Gu, Yan Shi, Katsuhiko Nosho, Teppei Morikawa, Kentaro Inamura, Sachet A. Shukla, Catherine J. Wu, Levi A. Garraway, Xuehong Zhang, Kana Wu, Jeffrey A. Meyerhardt, Andrew T. Chan, Jonathan N. Glickman, Scott J. Rodig, Gordon J. Freeman, Charles S. Fuchs, Reiko Nishihara, Marios Giannakis, Shuji Ogino
Publikováno v:
OncoImmunology, Vol 7, Iss 7 (2018)
Inhibitors targeting the PDCD1 (programmed cell death 1, PD-1) immune checkpoint pathway have revolutionized cancer treatment strategies. The TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PDCD1 ligand 1, PD-L1) ex
Externí odkaz:
https://doaj.org/article/63ee06ae114e4a4fba2cde1620b7523b