Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Molecular lesion"'
Autor:
Ioannis A Voutsadakis
Publikováno v:
Current Oncology, Vol 28, Iss 251, Pp 2868-2880 (2021)
Current Oncology
Volume 28
Issue 4
Pages 251-2880
Current Oncology
Volume 28
Issue 4
Pages 251-2880
Background: Squamous carcinomas of the uterine cervix often carry mutations of the gene encoding for the catalytic sub-unit of kinase PI3K, PIK3CA. The locus of this gene at chromosome 3q26 and neighboring loci are also commonly amplified. The landsc
Autor:
Georgina L Ryland, Jasmine Singh, Piers Blombery, Gareth P. Gregory, Adam Facey, Fran O’Malley
Publikováno v:
Leukemialymphoma. 62(12)
Acute promyelocytic leukemia (APL) is a hematological emergency requiring rapid initiation of therapy due to potentially fatal complications including disseminated intravascular coagulopathy. Clini...
Publikováno v:
Cureus
Sickle cell anemia (SCA) is a hereditary hemoglobin (Hb) disorder associated with a very specific molecular lesion, which is the exchange of glutamic acid for valine in the sixth residue of the Hb beta chain, originating the S Hb. It is characterized
Autor:
Hiroki Kubota, Daiki Kondo, Ikuko Takahashi, Yoko Sato, Miyuki Toyono, Atsuko Noguchi, Yukio Sawaishi, Tamami Yano, Tsutomu Takahashi
Publikováno v:
Brain and Development. 40:760-767
Objective To reveal a molecular lesion in the ZC4H2 gene in a Japanese family with arthrogryposis multiplex congenita (AMC) and intellectual disability (ID), and to characterize clinical features of patients with ZC4H2 gene mutations through a litera
Autor:
K. H. Chadwick
Publikováno v:
Understanding Radiation Biology ISBN: 9780429288197
Understanding Radiation Biology
Understanding Radiation Biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d864313034f984444339c6b3e39108a
https://doi.org/10.1201/9780429288197-3
https://doi.org/10.1201/9780429288197-3
Autor:
Federico Garrido
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030178635
The impact of HLA class I loss in cancer immunotherapy is carefully analyzed. Why some metastatic lesions regress and other progress after immunotherapy? Are T lymphocytes responsible for tumour rejection and how these responses can be boosted? These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35bdc9ea076567088be32a1ba7ff503a
https://doi.org/10.1007/978-3-030-17864-2_3
https://doi.org/10.1007/978-3-030-17864-2_3
Mitochondrial permeability transition, as the consequence of opening of a mitochondrial permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse and cell death, it has been implicated in the pathophysiology of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f5b4191563f8364fdcaaa44f07a1de
http://hdl.handle.net/11577/3350037
http://hdl.handle.net/11577/3350037
Publikováno v:
Experimental Oncology. 38:112-116
Aim: To evaluate real-time polymerase chain reaction (PCR) assay system for detection of NOTCH1 c.7541_754delCT mutation in chronic lymphocytic leukemia (CLL) patients. Material and Methods: A total of 325 CLL patients were included in the study. Scr
Autor:
Deepika S. Darbari, Samir K. Ballas
Publikováno v:
Complementary Therapies in Medicine. 49:102327
Sickle cell disease (SCD) is a highly complex inherited disorder of hemoglobin structure. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing multiple phenotypic expressions that constitute the v
Publikováno v:
British Journal of Haematology. 169:401-414
B-precursor acute lymphoblastic leukaemia (BPL) is the most common form of cancer in children and adolescents. Our recent studies have demonstrated that CD22ΔE12 is a characteristic genetic defect of therapy-refractory clones in paediatric BPL and i