Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Molecular initiating event"'
Autor:
Domenico Gadaleta, Marina Garcia de Lomana, Eva Serrano-Candelas, Rita Ortega-Vallbona, Rafael Gozalbes, Alessandra Roncaglioni, Emilio Benfenati
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract The adverse outcome pathway (AOP) concept has gained attention as a way to explore the mechanism of chemical toxicity. In this study, quantitative structure–activity relationship (QSAR) models were developed to predict compound activity to
Externí odkaz:
https://doaj.org/article/f64a73920b77456f89cbc33ac1b0126b
Autor:
Moena Kagaya, Yoshihiro Uesawa
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1086 (2024)
Oral mucositis (OM) is one of the common adverse events associated with cancer treatment that decreases the quality of life and affects treatment outcomes. However, the medications used to manage OM are generally only palliative, and our knowledge of
Externí odkaz:
https://doaj.org/article/b3a9042253004eff9ded3109875ded5f
Autor:
Miao Guan, Xiaoyang Wang, Xinyuan Xu, Tianqi Ling, Jing Wu, Jinjun Qian, Fei Ma, Xiaowei Zhang
Publikováno v:
Environment International, Vol 186, Iss , Pp 108596- (2024)
Organophosphate flame retardants (OPFRs) have been widely detected in multiple environment media and have many adverse effects with complex toxicity mechanisms. However, the early molecular responses to OPFRs have not been fully elucidated, thereby m
Externí odkaz:
https://doaj.org/article/920cc26e71da4291b6e8ae21e479d2c7
Publikováno v:
Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-23 (2023)
Abstract Background Adverse outcome pathways (AOPs) are conceptual frameworks that organize knowledge about biological interactions and toxicity mechanisms. They present a sequence of events commencing with initial interaction(s) of a stressor, which
Externí odkaz:
https://doaj.org/article/c21b87464b374714b5b70feefe897566
Akademický článek
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Publikováno v:
Journal of Xenobiotics, Vol 12, Iss 3, Pp 145-157 (2022)
Since 1974, more than 800 disinfection byproducts (DBPs) have been identified from disinfected drinking water, swimming pool water, wastewaters, etc. Some DBPs are recognized as contaminants of high environmental concern because they may induce many
Externí odkaz:
https://doaj.org/article/717f710e995d407aa9fc86daad63573a
Publikováno v:
Environment International, Vol 170, Iss , Pp 107584- (2022)
As the primary molecular target, there is still a gap between the peroxisome proliferator-activated receptors (PPARs) regulation and the adverse health effects caused by per- and polyfluoroalkyl substances (PFASs). The effects of PFASs on cellular di
Externí odkaz:
https://doaj.org/article/f688674fc5474884ae22b2dfabb58efb
Akademický článek
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Publikováno v:
Toxics, Vol 11, Iss 2, p 189 (2023)
The impact of exposure to multiple chemicals raises concerns for human and environmental health. The adverse outcome pathway method offers a framework to support mechanism-based assessment in environmental health starting by describing which mechanis
Externí odkaz:
https://doaj.org/article/fec9cbb613874171b28f1bb86fd897b1
Akademický článek
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