Výsledky vyhledávání - "Molecular bacterial load assay"

Akademický článek

Tuberculosis patients with diabetes co-morbidity experience reduced Mycobacterium tuberculosis complex clearance

Autor: Emelia Konadu Danso, Prince Asare, Stephen Osei-Wusu, Phillip Tetteh, Amanda Yaa Tetteh, Augustine Asare Boadu, Ivy Naa Koshie Lamptey, Augustina Angelina Sylverken, Kwasi Obiri-Danso, Jane Afriyie Mensah, Abraham Adjei, Dorothy Yeboah-Manu

Publikováno v: Heliyon, Vol 10, Iss 15, Pp e35670- (2024)

Objective: This study aimed to investigate the impact of diabetes mellitus (DM) on tuberculosis (TB) treatment response using bacterial clearance as a surrogate marker. Method: We compared smear microscopy, culture, and tuberculosis molecular bacteri

Externí odkaz: https://doaj.org/article/85f9dc27cba448fdac6bb58af09f8773

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Akademický článek

Reduction of blood C-reactive protein concentration complements the resolution of sputum bacillary load in patients on anti-tuberculosis therapy

Autor: Khalide Azam, Celso Khosa, Sofia Viegas, Isabel Massango, Nilesh Bhatt, Ilesh Jani, Norbert Heinrich, Michael Hoelscher, Stephen H. Gillespie, Andrea Rachow, Wilber Sabiiti

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundTuberculosis (TB) is a difficult-to-treat disease requiring the combination of four antibiotics for a minimum of 6 months. Rapid and quantitative biomarkers to monitor treatment response are urgently needed for individual patient management

Externí odkaz: https://doaj.org/article/147a9f2704fc47c989b9c6a134894438

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Akademický článek

High Mycobacterium tuberculosis Bacillary Loads Detected by Tuberculosis Molecular Bacterial Load Assay in Patient Stool: a Potential Alternative for Nonsputum Diagnosis and Treatment Response Monitoring of Tuberculosis

Autor: Emmanuel Musisi, Abdul Sessolo, Sylvia Kaswabuli, Josephine Zawedde, Patrick Byanyima, Shariifah Kasinga, Ingvar Sanyu, Esther Uwimaana, Stanley Walimbwa, Joseph Olore, Willy Ssengooba, Christine Sekaggya, Moses L. Joloba, William Worodria, Laurence Huang, Stephen H. Gillespie, Derek J. Sloan, Wilber Sabiiti

Publikováno v: Microbiology Spectrum, Vol 10, Iss 1 (2022)

ABSTRACT Not all patients produce sputum, yet most available TB tests use sputum. We investigated the utility of a novel RNA-based quantitative test, the tuberculosis molecular bacterial load assay (TB-MBLA), for the detection and quantification of M

Externí odkaz: https://doaj.org/article/1b34d326aad843688cace72aeab22c51

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Performance of Tuberculosis Molecular Bacterial Load Assay Compared to Alere TB-LAM in Urine of Pulmonary Tuberculosis Patients with HIV Co-Infections

Autor: Daniel Adon Mapamba, Elingarami Sauli, Julieth Lalashowi, Joram Buza, Joseph John, Zawadi Mwaisango, Peter Tarmo, Issa Sabi, Andrea Rachow, Nyanda Elias Ntinginya, Bariki Mtafya

Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3715

Alternative tools are needed to improve the detection of M. tuberculosis (M. tb) in HIV co-infections. We evaluated the utility of Tuberculosis Molecular Bacterial Load Assay (TB-MBLA) compared to lipoarabinomannan (LAM) to detect M. tb in urine. Spu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd44e104c90ae97de53ea3ca3d58c4c

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Mycobactericidal Effects of Different Regimens Measured by Molecular Bacterial Load Assay among People Treated for Multidrug-Resistant Tuberculosis in Tanzania

Autor: Sayoki Mfinanga, Elingarami Sauli, Stephen H. Gillespie, Wilber Sabiiti, Katharina S. Kreppel, Nyanda E. Ntinginya, Scott K. Heysell, Emmanuel A. Mpolya, Kennedy Kwasi Addo, Peter M. Mbelele, Bariki Mtafya, Stellah G. Mpagama, Patrick P. J. Phillips

Publikováno v: Journal of Clinical Microbiology
Journal of clinical microbiology, vol 59, iss 4

Rifampin or multidrug-resistant tuberculosis (RR/MDR-TB) treatment has largely transitioned to regimens free of the injectable aminoglycoside component, despite the drug class’ purported bactericidal activity early in treatment. We tested whether M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1364dff60125d673d17b2aa750ada276
https://doi.org/10.1128/jcm.02927-20

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United Kingdom–East and Southern Africa partnership at the forefront of developing first ever test that measures patient tuberculosis burden in hours

Autor: Sabiiti, Wilber, MBLA development stakeholders

EDCTP for funding the development and trialling of the Molecular bacterial load assay test. GCRF, SCF, PanACEA and University of St Andrews School of Medicine for funding the MBLA stakeholders conference. We acknowledge funding from European and Deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______901::088d3d3f653b654fa7da20d075a9b88e
https://www.editorialmanager.com/easci/Default.aspx?pg=login.asp&username=&a=r

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Pharmacometric Models to Improve the Treatment and Development of Drugs against Tuberculosis

Autor: Svensson, Robin J.

With 10 million new infections yearly, tuberculosis has a major impact on the human well-being of the world. Most patients have infections susceptible to a first-line treatment with a treatment success rate of 80%, a number that can potentially be im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::efbeca77cfefcacf09ffdfba5617b98c
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-379359

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