Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat

Autor: Jessica R. Ivy, Linda J. Mullins, Jon Manning, Natalia Rakova, Kento Kitada, Olav Tenstad, Helge Wiig, Dominik N. Müller, Mairi Ward, John J. Mullins

Publikováno v: Pflügers Archiv: European Journal of Physiology.
Pflugers Archiv
Mullins, L, Ivy, J, Ward, M, Tenstad, O, Wiig, H, Kitada, K, Manning, J, Rakova, N, Muller, D & Mullins, J 2021, ' Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat ', Pflügers Archiv European Journal of Physiology, pp. 897 . https://doi.org/10.1007/s00424-021-02582-7

We discovered high Na+ and water content in the skin of newborn Sprague–Dawley rats, which reduced ~ 2.5-fold by 7 days of age, indicating rapid changes in extracellular volume (ECV). Equivalent changes in ECV post birth were also observed in C57Bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50418c88ceb539942a456c47d4d1b1f8
https://hdl.handle.net/11250/2838410

Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice

Autor: Anneke Koeman, Coert J. Zuurbier, Arnold de Haan, Gert Schaart, Rick Bezemer, Can Ince, Kirsten M. Smeele, Markku Laakso, Maarten R. Drost, Markus W. Hollmann, Otto Eerbeek, Sami Heikkinen

Publikováno v: Pflugers Archiv, 459(5), 705-712. Springer Verlag
Pflügers Archiv European Journal of Physiology, 459(5), 705-712. Springer Verlag
Plügers Archiv, 459(5), 705-712. Springer Verlag
Smeele, K M, Eerbeek, O, Koeman, A, Bezemer, R, Ince, C, Heikkinen, S, Laakso, M, de Haan, A, Schaart, G, Drost, M R, Hollmann, M W & Zuurbier, C J 2010, ' Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice ', Pflügers Archiv European Journal of Physiology, vol. 459, no. 5, pp. 705-712 . https://doi.org/10.1007/s00424-010-0787-3
Pflugers Archiv-European Journal of Physiology, 459(5), 705-712. Springer Verlag
Pflugers Archiv

Cellular studies have demonstrated a protective role of mitochondrial hexokinase against oxidative insults. It is unknown whether HK protective effects translate to the in vivo condition. In the present study, we hypothesize that HK affects acute isc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0040863d1c594fe52eb66b567ceef413
https://hdl.handle.net/11245/1.341342

Consequences of perinatal treatment with l-arginine and antioxidants for the renal transcriptome in spontaneously hypertensive rats

Autor: Sebastiaan Wesseling, Jaap A. Joles, Maarten P. Koeners, Branko Braam, Farid Kantouh

Publikováno v: Pflugers Archiv

Treating spontaneously hypertensive rats (SHR) with L-arginine, taurine, and vitamins C and E (ATCE) during nephrogenesis (2 weeks before to 4 weeks after birth) persistently lowers blood pressure. Hypothetically, differential gene expression in kidn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d374dc48a20a323e1806bf07cc203b74
https://doi.org/10.1007/s00424-009-0639-1

Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain

Autor: Yusef, YR, Zuniga, L, Catalan, M, Niemeyer, MI, Cid, LP, Sepulveda, FV

Publikováno v: JOURNAL OF PHYSIOLOGY (LONDON PRINT)
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Functional and structural studies demonstrate that Cl(-) channels of the ClC family have a dimeric double-barrelled structure, with each monomer contributing an identical pore. Studies with ClC-0, the prototype ClC channel, show the presence of indep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f85e509a3c34d48161f8189eb8d16dbf
https://europepmc.org/articles/PMC1779660/

Modes and models of GABA(A) receptor gating

Autor: Gareth M C, Lema, Anthony, Auerbach

Publikováno v: The Journal of physiology. 572(Pt 1)

Upon activation by agonist, the type A gamma-aminobutyric acid receptor (GABAR) 'gates', allowing chloride ions to permeate membranes and produce fast inhibition of neurons. There is no consensus kinetic model for the GABAR gating mechanism. We expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e0a4c8ac8a35cb44af39ae741860169
https://pubmed.ncbi.nlm.nih.gov/16455693