Zobrazeno 1 - 10
of 7 809
pro vyhledávání: '"Molecular Targets"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Objective: Type 2 diabetes (T2D) is a chronic metabolic disorder characterized by reduced responsiveness of body cells to insulin, leading to elevated blood sugar levels. CNOT6L is involved in glucose metabolism, insulin secretion regulation
Externí odkaz:
https://doaj.org/article/8edb9befbc9b4f7789cb7e6aa05a8830
Publikováno v:
Beni-Suef University Journal of Basic and Applied Sciences, Vol 13, Iss 1, Pp 1-17 (2024)
Abstract Background Uncontrolled cell proliferation is a major cause of cancer development and progression. Inflammation along with inflammatory mediators and cells play a significant role in cancer. Cancer ranks in second in mortality rates, followi
Externí odkaz:
https://doaj.org/article/dcbb0955cebc4bbd9fa849c3f5e78bc6
Autor:
Basiru Olaitan Ajiboye, Toluwase Hezekiah Fatoki, Olamilekan Ganiu Akinola, Kazeem Olasunkanmi Ajeigbe, Abraham Fisayo Bamisaye, Eva-María Domínguez-Martín, Patricia Rijo, Babatunji Emmanuel Oyinloye
Publikováno v:
BMC Urology, Vol 24, Iss 1, Pp 1-21 (2024)
Abstract Prostate cancer (PCa) is a complex and biologically diverse disease with no curative treatment options at present. This study aims to utilize computational methods to explore potential anti-PCa compounds based on differentially expressed gen
Externí odkaz:
https://doaj.org/article/f213c29bbcba4fd79898f4ca5ad2d97e
Autor:
Liangliang He, Aijing Li, Ping Yu, Shumin Qin, Hor-Yue Tan, Denglang Zou, Haomeng Wu, Shuai Wang
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107461- (2024)
Digestive inflammation is a widespread global issue that significantly impacts quality of life. Recent advances have highlighted the unique potential of therapeutic peptides for treating this condition, owing to their specific bioactivity and high sp
Externí odkaz:
https://doaj.org/article/330cc8e88ddf43789b4866e0eef9414f
Autor:
Dominika Nielipińska, Dominika Rubiak, Agnieszka J. Pietrzyk-Brzezińska, Joanna Małolepsza, Katarzyna M. Błażewska, Edyta Gendaszewska-Darmach
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117496- (2024)
The field of peptide drug research has experienced notable progress, with stapled peptides featuring stabilized α-helical conformation, emerging as a promising field. These peptides offer enhanced stability, cellular permeability, and binding affini
Externí odkaz:
https://doaj.org/article/773afa7c63c34fc7826e04d161c4578c
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37323- (2024)
Cancer is a disease characterized by uncontrolled cell proliferation, leading to excessive growth and invasion that can spread to other parts of the body. Traditional Chinese medicine has made new advancements in the treatment of cancer, providing ne
Externí odkaz:
https://doaj.org/article/e7be0c721277418a967d28ab96c9cd9a
Autor:
Soberanis Pina P, Lheureux S
Publikováno v:
Biologics: Targets & Therapy, Vol Volume 18, Pp 79-93 (2024)
Pamela Soberanis Pina, Stephanie Lheureux Department of Medical Oncology, Princess Margaret Cancer Centre, Toronto, ON, CanadaCorrespondence: Stephanie Lheureux, Princess Margaret Cancer Centre, 700 University Avenue, Toronto, M5G 1Z5, Ontario, Canad
Externí odkaz:
https://doaj.org/article/b417f6526579476aa35fef5d1b51fc20
Publikováno v:
Discover Nano, Vol 19, Iss 1, Pp 1-29 (2024)
Abstract Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, and treatment responses. Categorization of subtypes is based on the presence or absence of
Externí odkaz:
https://doaj.org/article/a749151529db4d4b8c7da7421de11784
Publikováno v:
Environment Conservation Journal, Vol 25, Iss 3 (2024)
The emergence of non-albicans Candida as a potential causative agent of candidiasis following Candida albicans is occurring globally. It is known that phenolic cresols, thymol, and carvacrol have anti-Candida characteristics. However, there are few p
Externí odkaz:
https://doaj.org/article/08bec6631dc043e7a93d6b18e4830827
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117068- (2024)
Precancerous lesions of gastric cancer (PLGC) represent a critical pathological stage in the transformation from normal gastric mucosa to gastric cancer (GC). The global incidence of PLGC has been rising over the past few decades, with a trend toward
Externí odkaz:
https://doaj.org/article/709781444d64446fa525ddabb42863ce