Zobrazeno 1 - 10
of 480
pro vyhledávání: '"Molecular Mechanism of Gene Regulation"'
Autor:
Emir Malovic, Alyssa Ealy, Cameron Miller, Ahyoung Jang, Phillip J. Hsu, Souvarish Sarkar, Dharmin Rokad, Cody Goeser, Aleah Kristen Hartman, Allen Zhu, Bharathi Palanisamy, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Chuan He, Anumantha G. Kanthasamy
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110619- (2024)
Summary: As the most abundant glial cells in the central nervous system (CNS), astrocytes dynamically respond to neurotoxic stress, however, the key molecular regulators controlling the inflammatory status of these sentinels during neurotoxic stress
Externí odkaz:
https://doaj.org/article/644b233085804a1086375f92d94ebdfb
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109900- (2024)
Summary: Type 2 diabetes mellitus (T2DM) represents a common complication during pregnancy that affects fetoplacental development. We demonstrated the existence of impaired trophoblast syncytialization under hyperglycemic conditions. However, the exa
Externí odkaz:
https://doaj.org/article/4dc68c2c35c34a36b2ee004c3630115c
Autor:
Mengjia Li, Haocheng Shou, Guillermo Martínez Corrales, Tatiana Svermova, Alessandra Vieira Franco, Nazif Alic
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109962- (2024)
Summary: Transcription factors can reprogram gene expression to promote longevity. Here, we investigate the role of Drosophila Xbp1. Xbp1 is activated by splicing of its primary transcript, Xbp1u, to generate Xbp1s, a key activator of the endoplasmic
Externí odkaz:
https://doaj.org/article/f18ff14b1908400a871d83a7709ddfbe
Autor:
Siyuan Hao, Ye Jin Lee, Nadav Benhamou Goldfajn, Eduardo Flores, Jindayi Liang, Hannah Fuehrer, Justin Demmerle, Jennifer Lippincott-Schwartz, Zhe Liu, Shahar Sukenik, Danfeng Cai
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109927- (2024)
Summary: YAP/TEAD signaling is essential for organismal development, cell proliferation, and cancer progression. As a transcriptional coactivator, how YAP activates its downstream target genes is incompletely understood. YAP forms biomolecular conden
Externí odkaz:
https://doaj.org/article/93e023ecedcf4265b02598fc8193056d
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109683- (2024)
Summary: Tissue development, homeostasis, and repair all require efficient progenitor expansion. Lysine-specific demethylase 1 (Lsd1) maintains plastic epigenetic states to promote progenitor proliferation while overexpressed Lsd1 protein causes onco
Externí odkaz:
https://doaj.org/article/c83d88ba382d48ed8c688f8e701bb034
Autor:
Xiangduo Kong, Nam Viet Nguyen, Yumeng Li, Jasmine Shaaban Sakr, Kate Williams, Sheila Sharifi, Jonathan Chau, Altay Bayrakci, Seiya Mizuno, Satoru Takahashi, Tohru Kiyono, Rabi Tawil, Ali Mortazavi, Kyoko Yokomori
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109357- (2024)
Summary: Facioscapulohumeral dystrophy (FSHD) is linked to contraction of D4Z4 repeats on chromosome 4q with SMCHD1 mutations acting as a disease modifier. D4Z4 heterochromatin disruption and abnormal upregulation of the transcription factor DUX4, en
Externí odkaz:
https://doaj.org/article/f69dcee0cc5f45588408be663a8a6bce
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109278- (2024)
Summary: Epigenetic modifications have emerged as key regulators of metabolism-related complex diseases including the alcoholic fatty liver disease (AFLD) prevalent chronic liver disorder with significant economic implications. Building upon previous
Externí odkaz:
https://doaj.org/article/b555b35b04f545ea888dd43a57a8ce1d
Autor:
William M. Yashar, Joseph Estabrook, Hannah D. Holly, Julia Somers, Olga Nikolova, Özgün Babur, Theodore P. Braun, Emek Demir
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109124- (2024)
Summary: Dysregulation of normal transcription factor activity is a common driver of disease. Therefore, the detection of aberrant transcription factor activity is important to understand disease pathogenesis. We have developed Priori, a method to pr
Externí odkaz:
https://doaj.org/article/aa9d06afed3e4a7cb380f40c38560ac4
Autor:
HaEun Kim, Benjamin Lebeau, David Papadopoli, Predrag Jovanovic, Mariana Russo, Daina Avizonis, Masahiro Morita, Farzaneh Afzali, Josie Ursini-Siegel, Lynne-Marie Postovit, Michael Witcher, Ivan Topisirovic
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109188- (2024)
Summary: Emerging data suggest a significant cross-talk between metabolic and epigenetic programs. However, the relationship between the mechanistic target of rapamycin (mTOR), which is a pivotal metabolic regulator, and epigenetic modifications rema
Externí odkaz:
https://doaj.org/article/85ce26f1f1e64b648c909029a5dc76ef
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109186- (2024)
Summary: Magnetogenetics represents a method for remote control of cellular function. Previous work suggests that generation of reactive oxygen species (ROS) initiates downstream signaling. Herein, a chemical biology approach was used to elucidate fu
Externí odkaz:
https://doaj.org/article/60e6d65975824a90aa6e7c8cc7e14917