Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Molecular Genetics of Complex Traits"'
Autor:
Lu Lu, Scott A. Heldt, Kristin M. Hamre, Robert W. Williams, Jessica A. Baker, Melloni N. Cook
Publikováno v:
Physiological Genomics. 47:308-317
Alcoholism, stress, and anxiety are strongly interacting heritable, polygenetic traits. In a previous study, we identified a quantitative trait locus (QTL) on murine chromosome (Chr) 1 between 23.0 and 31.5 Mb that modulates genetic differences in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a90d0945d182ff806c6bebf9988108
https://doi.org/10.1152/physiolgenomics.00114.2014
https://doi.org/10.1152/physiolgenomics.00114.2014
Autor:
Enrique Vargas, Lorna G. Moore, Abigail W. Bigham, Vaughn A. Browne, Colleen G. Julian, Mark D. Shriver, Megan J. Wilson
Publikováno v:
Physiological Genomics. 46:687-697
Low birth weight and intrauterine growth restriction (IUGR) increase the risk of mortality and morbidity during the perinatal period as well as in adulthood. Environmental and genetic factors contribute to IUGR, but the influence of maternal genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baa49d08f133b9de26a7ceff7397360
https://doi.org/10.1152/physiolgenomics.00063.2014
https://doi.org/10.1152/physiolgenomics.00063.2014
Autor:
Falak, S., Schafer, S., Baud, A., Hummel, O., Schulz, H., Gauguier, D., Hubner, N., Osborne-Pellegrin, M.
Publikováno v:
Physiological Genomics
The inbred Brown Norway (BN) rat develops spontaneous ruptures of the internal elastic lamina (RIEL) of the abdominal aorta (AA) and iliac arteries. Prior studies with crosses of the BN/Orl RJ (susceptible) and LOU/M (resistant) showed the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::36b2362be3e3536225cd260924ccd0b8
http://europepmc.org/articles/PMC4060037
http://europepmc.org/articles/PMC4060037
Publikováno v:
Physiological Genomics. 45:917-923
Osterix ( Osx) is essential for both intramembranous or endochondral bone formation. Osteoblast-specific ablation of Osx using Col1α1-Cre resulted in osteopenia, because of impaired osteoblast differentiation in adult mice. Since Osx is also known t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5d01c393675cf2fa8a1fef0699007e
https://doi.org/10.1152/physiolgenomics.00111.2013
https://doi.org/10.1152/physiolgenomics.00111.2013
Publikováno v:
Physiological Genomics. 45:606-614
We initiated a large-scale bidirectional selection experiment in a genetically heterogeneous rat population (N/NIH stock, n = 152) to develop lines of low response trainers (LRT) and high response trainers (HRT) as a contrasting animal model system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79eb54648fe0c33355308285d5c2aee
https://doi.org/10.1152/physiolgenomics.00021.2013
https://doi.org/10.1152/physiolgenomics.00021.2013
Publikováno v:
Physiological Genomics. 45:552-564
Cia4 is a locus on rat chromosome 7 that regulates disease severity and joint damage in models of rheumatoid arthritis, including pristane-induced arthritis (PIA). To identify molecular processes regulated by Cia4, synovial tissues from MHC-identical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d338204f01f8db2b10c62678f995b3ef
https://doi.org/10.1152/physiolgenomics.00029.2013
https://doi.org/10.1152/physiolgenomics.00029.2013
Publikováno v:
Physiological genomics, 47(10): 470-478
The genetic relationship between immune responsiveness and performance is not well understood, but a major topic of the evolution of resource allocation and of relevance in human medicine and livestock breeding, for instance. This study aims to show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a327f5599c06b5bab7c67f36a0326730
https://europepmc.org/articles/PMC4593825/
https://europepmc.org/articles/PMC4593825/
Autor:
Jeremy W. Prokop, Fabiano C. Araujo, Jozef Lazar, Robson A.S. Santos, Helen L. Del Puerto, Ingrid Kazue Mizuno Watanabe, Amy Milsted, Fernando M. Reis
The renin-angiotensin system (RAS) is subject to sex-specific modulation by hormones and gene products. However, sex differences in the balance between the vasoconstrictor/proliferative ACE/ANG II/AT1 axis, and the vasodilator/antiproliferative ACE2/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ad25e3df9a7a7bcb47a688010c3c72
https://europepmc.org/articles/PMC4421791/
https://europepmc.org/articles/PMC4421791/
Autor:
Bradford C. Berk, Tamlyn N. Thomas, Chenjing Wang, Elaine M. Smolock, Martha L. Zettel, Xing Qiu, Vyacheslav A. Korshunov, Sri N. Batchu, Keigi Fujiwara, Ryan M. Burke
Publikováno v:
Physiological genomics. 46(17)
Carotid intima formation is a significant risk factor for cardiovascular disease. C3H/FeJ (C3H/F) and SJL/J (SJL) inbred mouse strains differ in susceptibility to immune and vascular traits. Using a congenic approach we demonstrated that the Intima m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e473aa1fe360ebf70f2a112c3233c2f
https://pubmed.ncbi.nlm.nih.gov/24986958
https://pubmed.ncbi.nlm.nih.gov/24986958
Publikováno v:
Physiological genomics. 46(16)
Motivation and ability both underlie voluntary exercise, each with a potentially unique genetic architecture. Muscle structure and function are one of many morphological and physiological systems acting to simultaneously determine exercise ability. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd8b856c2269e9553f9062a5bfb0533
https://pubmed.ncbi.nlm.nih.gov/24939925
https://pubmed.ncbi.nlm.nih.gov/24939925