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pro vyhledávání: '"Molecular Developmental Biology"'
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Publikováno v:
Biochemical Society Transactions, 51, 1-12
Biochemical Society Transactions, 51, 1, pp. 1-12
Biochemical Society Transactions, 51, 1, pp. 1-12
Gene regulatory networks (GRNs) serve as useful abstractions to understand transcriptional dynamics in developmental systems. Computational prediction of GRNs has been successfully applied to genome-wide gene expression measurements with the advent o
Autor:
Christian Osterburg, Marco Ferniani, Dario Antonini, Ann-Sophie Frombach, Ludovica D’Auria, Susanne Osterburg, Rebecca Lotz, Frank Löhr, Sebastian Kehrloesser, Huiqing Zhou, Caterina Missero, Volker Dötsch
Publikováno v:
Cell Death and Disease, 14, 4
Cell Death and Disease, 14
Cell Death and Disease, 14
The transcription factor p63 shares a high sequence identity with the tumour suppressor p53 which manifests itself in high structural similarity and preference for DNA sequences. Mutations in the DNA binding domain (DBD) of p53 have been studied in g
Autor:
Raterman, Sophie T., Von Den Hoff, Johannes W., Dijkstra, Sietske, De Vriend, Cheyenne, Te Morsche, Tim, Broekman, Sanne, Zethof, Jan, De Vrieze, Erik, Wagener, Frank A. D. T. G., Metz, Juriaan R.
Publikováno v:
Frontiers in Cell and Developmental Biology, 11
Introduction: Mutations in the FOXE1 gene are implicated in cleft palate and thyroid dysgenesis in humans.Methods: To investigate whether zebrafish could provide meaningful insights into the etiology of developmental defects in humans related to FOXE
Autor:
A.U. Abeysekara, A. Albert, R. Alfaro, C. Alvarez, J.D. Álvarez, M. Araya, J.C. Arteaga-Velázquez, K.P. Arunbabu, D. Avila Rojas, H.A. Ayala Solares, R. Babu, A.S. Barber, A. Becerril, E. Belmont-Moreno, S.Y. BenZvi, O. Blanco, J. Braun, C. Brisbois, K.S. Caballero-Mora, J.I. Cabrera Martínez, T. Capistrán, A. Carramiñana, S. Casanova, M. Castillo, O. Chaparro-Amaro, U. Cotti, J. Cotzomi, S. Coutiño de León, E. de la Fuente, C. de León, T. De Young, R. Diaz Hernandez, B.L. Dingus, M.A. DuVernois, M. Durocher, J.C. Díaz-Vélez, R.W. Ellsworth, K. Engel, C. Espinoza, K.L. Fan, K. Fang, B. Fick, H. Fleischhack, J.L. Flores, N. Fraija, J.A. García-González, G. Garcia-Torales, F. Garfias, G. Giacinti, H. Goksu, M.M. González, A. González-Muñoz, J.A. Goodman, J.P. Harding, E. Hernandez, S. Hernandez, J. Hinton, B. Hona, D. Huang, F. Hueyotl-Zahuantitla, C.M. Hui, T.B. Humensky, P. Hüntemeyer, A. Iriarte, A. Imran, A. Jardin-Blicq, V. Joshi, S. Kaufmann, D. Kieda, G.J. Kunde, A. Lara, R. Lauer, W.H. Lee, D. Lennarz, H. León Vargas, J.T. Linnemann, A.L. Longinotti, G. Luis-Raya, J. Lundeen, K. Malone, V. Marandon, A. Marinelli, O. Martinez, I. Martínez-Castellanos, J. Martínez-Castro, H. Martínez-Huerta, J.A. Matthews, P. Miranda-Romagnoli, T. Montaruli, J.A. Morales-Soto, E. Moreno, M. Mostafá, A. Nayerhoda, L. Nellen, M. Newbold, M.U. Nisa, R. Noriega-Papaqui, T. Oceguera-Becerra, L. Olivera-Nieto, N. Omodei, A. Peisker, Y. Pérez Araujo, E.G. Pérez-Pérez, E. Ponce, J. Pretz, C.D. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, F. Salesa Greus, A. Sandoval, M. Schneider, H. Schoorlemmer, J. Serna-Franco, G. Sinnis, A.J. Smith, Y. Son, K. Sparks Woodle, R.W. Springer, I. Taboada, A. Tepe, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Ureña-Mena, T.N. Ukwatta, E. Varela, M. Vargas-Magaña, L. Villaseñor, X. Wang, I.J. Watson, F. Werner, S. Westerhoff, E. Willox, I. Wisher, J. Wood, G.B. Yodh, D. Zaborov, A. Zepeda, H. Zhou
Publikováno v:
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1052, pp. 1-18
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1052, 1-18
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1052, 1-18
The High-Altitude Water Cherenkov (HAWC) observatory is a second-generation continuously operated, wide field-of-view, TeV gamma-ray observatory. The HAWC observatory and its analysis techniques build on experience of the Milagro experiment in using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3565e62a8a8b85b47f9b6c1643f875
Autor:
Gijs Rikken, Kayla J. Smith, Noa J.M. van den Brink, Jos P.H. Smits, Krishne Gowda, Angela Alnemri, Gulsum E. Kuzu, Iain A. Murray, Jyh-Ming Lin, Jos G.A. Smits, Ivonne M. van Vlijmen-Willems, Shantu G. Amin, Gary H. Perdew, Ellen H. van den Bogaard
Publikováno v:
Biochemical Pharmacology, 208
Therapeutic aryl hydrocarbon receptor (AHR) modulating agents gained attention in dermatology as non-steroidal anti-inflammatory drugs that improve skin barrier properties. By exploiting AHR's known ligand promiscuity, we generated novel AHR modulati
Publikováno v:
Bioinformatics, 39, 3, pp. 1-3
Bioinformatics, 39, 1-3
Bioinformatics, 39, 1-3
MotivationAnalyzing a functional genomics experiment, such as ATAC-, ChIP-, or RNA-sequencing, requires genomic resources such as a reference genome assembly and gene annotation. These data can generally be retrieved from different organizations and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f8444ae0106d583be47c6ee2c36a4b
https://doi.org/10.1093/bioinformatics/btad119
https://doi.org/10.1093/bioinformatics/btad119
Autor:
Jesper V. Olsen, Jos G. A. Smits, Sonia Minuzzo, Giulia Franciosa, Ana Martinez-Val, Stefano Indraccolo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, 12, 1-19
Nature Communications, 12, 1, pp. 1-19
Nature Communications
Franciosa, G, Smits, J G A, Minuzzo, S, Martinez-Val, A, Indraccolo, S & Olsen, J V 2021, ' Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures ', Nature Communications, vol. 12, no. 1, 2507 . https://doi.org/10.1038/s41467-021-22787-9
Nature Communications, 12, 1-19
Nature Communications, 12, 1, pp. 1-19
Nature Communications
Franciosa, G, Smits, J G A, Minuzzo, S, Martinez-Val, A, Indraccolo, S & Olsen, J V 2021, ' Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures ', Nature Communications, vol. 12, no. 1, 2507 . https://doi.org/10.1038/s41467-021-22787-9
Notch1 is a crucial oncogenic driver in T-cell acute lymphoblastic leukemia (T-ALL), making it an attractive therapeutic target. However, the success of targeted therapy using γ-secretase inhibitors (GSIs), small molecules blocking Notch cleavage an
Autor:
B. M. H. Heuts, S. Arza-Apalategi, S. Frölich, S. M. Bergevoet, S. N. van den Oever, S. J. van Heeringen, B. A. van der Reijden, J. H. A. Martens
Publikováno v:
Scientific Reports, 12, 1-12
Scientific Reports, 12, 1, pp. 1-12
Scientific Reports, 12, 1, pp. 1-12
Advanced computational methods exploit gene expression and epigenetic datasets to predict gene regulatory networks controlled by transcription factors (TFs). These methods have identified cell fate determining TFs but require large amounts of referen
Autor:
Ira L. Blitz, Rebekah M. Charney, Margaret B. Fish, Camden Jansen, Kitt D. Paraiso, Jeff Jiajing Zhou, Aaron M. Zorn, Yuuri Yasuoka, Gert Jan C. Veenstra, Ali Mortazavi, M. Wlizla, Jin Sun Cho, Ann Rose Bright, Ken W.Y. Cho, Norihiro Sudou, Masanori Taira
Publikováno v:
Cell reports, vol 38, iss 7
Cell Reports, 38, 7, pp. 1-23
Cell Reports, 38, 1-23
Cell Reports, 38, 7, pp. 1-23
Cell Reports, 38, 1-23
SummaryMesendodermal specification is one of the earliest events in embryogenesis, where cells first acquire distinct identities. Cell differentiation is a highly regulated process that involves the function of numerous transcription factors (TFs) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c724bc6ffdb1da3af7e947d8305c88e
https://escholarship.org/uc/item/1ms272nq
https://escholarship.org/uc/item/1ms272nq