Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Molecular Biology of Disease"'
Autor:
Jeroen Korving, Lena Böttinger, Norman Sachs, Peter J. Peters, Willine J. van de Wetering, Jelte van der Vaart, Kèvin Knoops, Kerem Eitan, Harry Begthel, Carmen López-Iglesias, Alex Gileles-Hillel, Hans Clevers, Maarten H. Geurts
Publikováno v:
EMBO Reports
Embo Reports, 22(12):e52058. Wiley
EMBO Reports, 22(12). Nature Publishing Group
Embo Reports, 22(12):e52058. Wiley
EMBO Reports, 22(12). Nature Publishing Group
Patient‐derived human organoids can be used to model a variety of diseases. Recently, we described conditions for long‐term expansion of human airway organoids (AOs) directly from healthy individuals and patients. Here, we first optimize differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd7a3bb097fb776aa98279eded1a78f
https://cris.maastrichtuniversity.nl/en/publications/b9053ec6-b63a-412d-a892-5bb118aba269
https://cris.maastrichtuniversity.nl/en/publications/b9053ec6-b63a-412d-a892-5bb118aba269
Autor:
Gabriella Viero, Sally Salomonsson, Alessandro Provenzani, Vito Giuseppe D'Agostino, Alessandro Quattrone, Angelo Poletti, Riccardo Cristofani, Paola Bellosta, Katherine M. Wilson, Michael Pancher, Nausicaa Valentina Licata, Valentina Adami, Deniz Vaizoglu, Daniele Pollini, Liam Kempthorne, Adrian M. Isaacs, Antonia Ratti, Rosa Loffredo
Publikováno v:
The EMBO Journal
EMBO journal (Online) (2021). doi:10.15252/embj.2020105026
info:cnr-pdr/source/autori:Licata N.V.; Cristofani R.; Salomonsson S.; Wilson K.M.; Kempthorne L.; Vaizoglu D.; D'Agostino V.G.; Pollini D.; Loffredo R.; Pancher M.; Adami V.; Bellosta P.; Ratti A.; Viero G.; Quattrone A.; Isaacs A.M.; Poletti A.; Provenzani A./titolo:C9orf72 ALS%2FFTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation/doi:10.15252%2Fembj.2020105026/rivista:EMBO journal (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
EMBO journal (Online) (2021). doi:10.15252/embj.2020105026
info:cnr-pdr/source/autori:Licata N.V.; Cristofani R.; Salomonsson S.; Wilson K.M.; Kempthorne L.; Vaizoglu D.; D'Agostino V.G.; Pollini D.; Loffredo R.; Pancher M.; Adami V.; Bellosta P.; Ratti A.; Viero G.; Quattrone A.; Isaacs A.M.; Poletti A.; Provenzani A./titolo:C9orf72 ALS%2FFTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation/doi:10.15252%2Fembj.2020105026/rivista:EMBO journal (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Intronic GGGGCC (G4C2) hexanucleotide repeat expansion within the human C9orf72 gene represents the most common cause of familial forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS/FTD). Repeat‐associated non‐AU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5824b02b046e8ef3ed27783335bbc380
http://europepmc.org/articles/PMC8724771
http://europepmc.org/articles/PMC8724771
Autor:
Shirin Doroudgar, Mirko Völkers, Hugo A. Katus, Mathias H. Konstandin, Norbert Frey, Claudia Stroh, C. S. Hofmann, Clara Sandmann, Jennifer Furkel, Ellen Malovrh, Agnieszka A. Gorska, Carsten Sticht, Lonny Jürgensen, Eshita Varma, Christoph Dieterich, Eva Riechert, Vivien Kmietczyk, Verena Kamuf-Schenk, Julie Ölschläger, Etienne Boileau
Publikováno v:
EMBO Reports
The mechanistic target of rapamycin (mTOR) promotes pathological remodeling in the heart by activating ribosomal biogenesis and mRNA translation. Inhibition of mTOR in cardiomyocytes is protective; however, a detailed role of mTOR in translational re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0925b49d2b414b3c173f034bc9c1a623
http://europepmc.org/articles/PMC8647021
http://europepmc.org/articles/PMC8647021
Autor:
Greta Yang, Shou-Hsien Huang, Tzung-Yan Chen, Ming-Guang Huang, Cicero Lee-Tian Chang, Shuo-Wen Hsu, Meng-Ting Yang, Tien-Fen Kuo, Chun-Yen Yang, Si-Tse Jiang, Ching-Shan Feng, Chung-Yu Huang, Keng-Chang Tsai, Tuan-Nan Wen, Wen-Chin Yang, Shu-Huei Kao
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 10, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine
Loss of β‐cell number and function is a hallmark of diabetes. β‐cell preservation is emerging as a promising strategy to treat and reverse diabetes. Here, we first found that Pdia4 was primarily expressed in β‐cells. This expression was up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a422f1979df710f913e95dc786707197
https://doaj.org/article/cdf054b19b8a4d15ad574bedf038d2a8
https://doaj.org/article/cdf054b19b8a4d15ad574bedf038d2a8
Autor:
Barbara Franke, Jennifer R. Fleming, Siegfried Labeit, Julius Bogomolovas, Alexander Gasch, Martin Scheffner, Bruno Manso, Marija Markovic, Bernd Simon, Ju Chen, Christine Peter, Olga Mayans, Ralph Knöll, Thomas Brunner
Publikováno v:
EMBO Reports
Striated muscle undergoes remodelling in response to mechanical and physiological stress, but little is known about the integration of such varied signals in the myofibril. The interaction of the elastic kinase region from sarcomeric titin (A168‐M1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34acee25ab40975dc0388f240b4bb290
https://doi.org/10.15252/embr.201948018
https://doi.org/10.15252/embr.201948018
Autor:
Hassan Jumaa, Timm Amendt
Publikováno v:
The EMBO Journal
The enormous diversity of antibody specificities is generated by random rearrangement of immunoglobulin gene segments and is important for general protection against pathogens. Since random rearrangement harbors the risk of producing self‐destructi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b69cc99628a966013c6cc85c80349d
https://doi.org/10.15252/embj.2020107621
https://doi.org/10.15252/embj.2020107621
Autor:
Katie J. Clowers, Joshua L. Bonkowsky, Ilka Wittig, James E. Cox, Minna Roh-Johnson, Esther Nuebel, Steven P. Gygi, Jordan A. Berg, Catherine Argyriou, Nancy Braverman, J. Alan Maschek, Chelsea U Kidwell, Jeffrey T. Morgan, Jared Rutter, Jacob M. Winter, Sandra Lettlova, Yu-Chan Chen, Lingxiao Chen, Sarah Fogarty
Publikováno v:
EMBO Reports
EMBO Rep
EMBO Rep
Zellweger spectrum disorder (ZSD) is the most severe peroxisomal biogenesis disorder (PBD). Why ZSD patients not only loose functional peroxisomes but also present with severe mitochondrial dysfunction was a long‐standing mystery. In this issue, Nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a6391349720e2952e843d111ddbfc6
https://doi.org/10.15252/embr.202051991
https://doi.org/10.15252/embr.202051991
Autor:
Alexandre Rosa Campos, Coralie Viollet, Ines Kollak, Martina Keck, Karsten Quast, Dagmar Knebel, Victoria Schroeder, James P. Garnett, Huy Quang Le, Jun Li, Benjamin Strobel, Franziska Herrmann, David J. Lamb, M.J. Thomas, Johannes Wirth, Heiko Stahl, Wioletta Skronska-Wasek, Eva Schruf, Matthew A Hill
Publikováno v:
EMBO Reports
Unveiling the molecular mechanisms of tissue remodelling following injury is imperative to elucidate its regenerative capacity and aberrant repair in disease. Using different omics approaches, we identified enhancer of zester homolog 2 (EZH2) as a ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30b077b28f61120a5c3812acdc2da51
https://www.repository.cam.ac.uk/handle/1810/331261
https://www.repository.cam.ac.uk/handle/1810/331261
Autor:
Emyr Lloyd-Evans, Magdalena A. Czubala, Thomas E. Phillips, Michael Sasner, Julie Williams, Neil Evans, Emily Maguire, Emma L Cope, Harriet M. Williams, Philip R. Taylor, Georgina E. Menzies, Rebecca Sims, Nicholas D. Allen, Gareth R. Howell
Publikováno v:
The EMBO Journal
Variants identified in genome‐wide association studies have implicated immune pathways in the development of Alzheimer’s disease (AD). Here, we investigated the mechanistic basis for protection from AD associated with PLCγ2 R522, a rare coding v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12986bb0f4ac7f823046c6231b09205
https://doi.org/10.15252/embj.2020105603
https://doi.org/10.15252/embj.2020105603
Autor:
Michael Ostrovsky, Amir Dori, Romana Weissova, Yarden Opatowsky, Roy Maimon, Sami J. Barmada, Eran Perlson, Gayster Alexandra, Elizabeth M. H. Tank, Topaz Altman, Natalia Shelestovich, Martin Balastik, Ariel Ionescu, Tal Gradus Pery, Lior Ankol
Publikováno v:
The EMBO Journal
Amyotrophic lateral sclerosis (ALS) is a fatal non‐cell‐autonomous neurodegenerative disease characterized by the loss of motor neurons (MNs). Mutations in CRMP4 are associated with ALS in patients, and elevated levels of CRMP4 are suggested to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1032758a11a26b7706bca88c678ab41
https://doi.org/10.15252/embj.2020107586
https://doi.org/10.15252/embj.2020107586