Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Molecular Biology Experimental Approach"'
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110856- (2024)
Summary: The capability of human pluripotent stem cells (hPSCs) to self-renew and differentiate into any cell type has greatly contributed to the advancement of biomedicine. Reporter lines derived from hPSCs have played a crucial role in elucidating
Externí odkaz:
https://doaj.org/article/b2eea1bdea8e47d0959140068e365d11
Autor:
Cheng Ma, Ramin Banan Sadeghian, Ryosuke Negoro, Kazuya Fujimoto, Toshikazu Araoka, Naoki Ishiguro, Minoru Takasato, Ryuji Yokokawa
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110760- (2024)
Summary: Renal transporters play critical roles in predicting potential drug-drug interactions. However, current in vitro models often fail to adequately express these transporters, particularly solute carrier proteins, including organic anion transp
Externí odkaz:
https://doaj.org/article/991f439ff2a947e5acef506476ba01c5
Autor:
Tian-Shu Kang, Yong-Ming Yan, Yuan Tian, Jun Zhang, Minghui Zhang, Yuxin Shu, Jinbo Huang, Jing He, Cheng-Tian Tao, Qian Zhu, Jinke Gu, Xiaopeng Lu, Yong-Xian Cheng, Wei-Guo Zhu
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110014- (2024)
Summary: The NAD+-dependent deacetylase SIRT7 is a pivotal regulator of DNA damage response (DDR) and a promising drug target for developing cancer therapeutics. However, limited progress has been made in SIRT7 modulator discovery. Here, we applied p
Externí odkaz:
https://doaj.org/article/713a4c4ce50a4b0a81c7306164ca42ef
Autor:
Anita Kneppers, Sabrina Ben Larbi, Marine Theret, Audrey Saugues, Carole Dabadie, Linda Gsaier, Arnaud Ferry, Philipp Rhein, Julien Gondin, Kei Sakamoto, Rémi Mounier
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108343- (2023)
Summary: Due to the post-mitotic nature of skeletal muscle fibers, adult muscle maintenance relies on dedicated muscle stem cells (MuSCs). In most physiological contexts, MuSCs support myofiber homeostasis by contributing to myonuclear accretion, whi
Externí odkaz:
https://doaj.org/article/90db3e235ff2447ba82fbd2e203ab358
Autor:
Zhou Yang, Xiyi Wei, Chengjian Ji, Xiaohan Ren, Wei Su, Yichun Wang, Jingwan Zhou, Zheng Zhao, Pengcheng Zhou, Kejie Zhao, Bing Yao, Ninghong Song, Chao Qin
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108148- (2023)
Summary: O-GlcNAc transferase (OGT) acts in the development of various cancers, but its role in clear cell renal cell carcinoma (ccRCC) remains unclear. In this study, we found that OGT was upregulated in ccRCC and this upregulation was associated wi
Externí odkaz:
https://doaj.org/article/16639bd3c1994becb2c88430fbe1a87a
Autor:
Shuai Chen, Peng Song, Yu Wang, Zeng Wang, Jiaming Xue, Yicheng Jiang, Yan Zhou, Jie Zhao, Liming Tang
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107756- (2023)
Summary: Circular RNA (circRNA) is a special category of non-coding RNA that has garnered increasing attention in the exploration of lipid metabolism. However, the functional regulation mechanisms of circRNAs in obesity diseases remain unclear. By wh
Externí odkaz:
https://doaj.org/article/37c05cefe8b64029b2b4066e4887239e
Autor:
Lingwei Peng, Xiaolian Zhang, Yuqin Du, Fan Li, Jiazheng Han, Oujin Liu, Shoulu Dai, Xiang Zhang, George E. Liu, Liguo Yang, Yang Zhou
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107753- (2023)
Summary: We performed direct RNA sequencing (DRS) together with PCR-amplified cDNA long and short read sequencing for cattle adipocyte at different stages. We proved that the DRS was with advantages to avoid artificial transcripts and questionable ex
Externí odkaz:
https://doaj.org/article/560582e163a946a4b3cfcb3874026351
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107379- (2023)
Summary: Arthrofibrosis (AF) is a debilitating complication that occurs after trauma or surgery, leading to functional impairment and surgical failures worldwide. This study aimed to uncover the underlying mechanism of AF. A total of 141 patients wer
Externí odkaz:
https://doaj.org/article/6b3dd2b7503c4647a5ebb37be3496abf
Autor:
JingJing Shang, Zhentang Yu, Chengwei Xiong, Junjie Zhang, Jinhong Gong, Changlin Yu, Yong Huang, Xindie Zhou
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107025- (2023)
Summary: Osteogenic differentiation (OD) of bone marrow mesenchymal stem cells (BMSCs) contributes significantly to the regeneration of bone defects. Resistin, an adipose tissue-specific secretory factor, has been shown to involve many different func
Externí odkaz:
https://doaj.org/article/18c4ed5824e24003b4da87fd308b3841
Autor:
Romain Fevre, Gaëtan Mary, Nadia Vertti-Quintero, Aude Durand, Raphaël F.-X. Tomasi, Elaine Del Nery, Charles N. Baroud
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106651- (2023)
Summary: Culturing and screening cells in microfluidics, particularly in three-dimensional formats, has the potential to impact diverse areas from fundamental biology to cancer precision medicine. Here, we use a platform based on anchored droplets fo
Externí odkaz:
https://doaj.org/article/6643fa5d831946cbbef6bb44e4278d1b