Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Molecular Biology/Translation Mechanisms"'
Publikováno v:
PLoS ONE
Background Tamoxifen is still the most widely used drug in hormone therapy for the treatment of breast cancer. Its benefits in adjuvant treatment are well documented in controlled and randomized clinical studies, which have demonstrated an increase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb56cd5561eea2a831a09b12f9594d05
https://pubmed.ncbi.nlm.nih.gov/18270579
https://pubmed.ncbi.nlm.nih.gov/18270579
Autor:
Birgit Seidelt, Shashi Bhushan, Jens Frauenfeld, Thomas Hoffmann, Thorsten Mielke, Otto Berninghausen, Roland Beckmann, Daniel N. Wilson
Publikováno v:
PLoS Biology, Vol 9, Iss 1, p e1000581 (2011)
PLoS Biology
PLoS Biology
A structure of a ribosome stalled during translation of the SecM peptide provides insight into the mechanism by which the large subunit active site is inactivated.
As nascent polypeptide chains are synthesized, they pass through a tunnel in the
As nascent polypeptide chains are synthesized, they pass through a tunnel in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24be6da517483871896722bc99e337da
http://europepmc.org/articles/PMC3022528?pdf=render
http://europepmc.org/articles/PMC3022528?pdf=render
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 11, p e13924 (2010)
PLoS ONE, Vol 5, Iss 11, p e13924 (2010)
Double subgenomic Sindbis virus (dsSINV) vectors are widely used for the expression of proteins, peptides, and RNA sequences. These recombinant RNA viruses permit high level expression of a heterologous sequence in a wide range of animals, tissues, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d1efaa21bf9dcfc6d43bb94ac8ba30
https://surrey.eprints-hosting.org/184877/
https://surrey.eprints-hosting.org/184877/
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 9, Pp 3307-3314 (2010)
PLoS ONE, Vol 5, Iss 9, Pp 3307-3314 (2010)
BACKGROUND: The multi-subunit eukaryotic initiation factor3 (eIF3) plays a central role in the initiation step of protein synthesis in eukaryotes. One of its large subunits, eIF3b, serves as a scaffold within eIF3 as it interacts with several other s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27bf32faf4ab0aa8bb1276d336f073e
http://europepmc.org/articles/PMC2940854
http://europepmc.org/articles/PMC2940854
Autor:
Philip G. Jones, Daniel P. Kelly, Howard L. McLeod, Amber L. Beitelshees, Sharon Cresci, Gerald W. Dorn, Janice M. Huss, John A. Spertus, Matt R Minton
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 9, p e12584 (2010)
PLoS ONE, Vol 5, Iss 9, p e12584 (2010)
Activation of peroxisome proliferator-activated receptor alpha (PPARα) occurs in animal models of diabetes (DM) and is implicated in pathological responses to myocardial ischemia. Using bioinformatics, we identified a single nucleotide polymorphism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2f6469562196c08828fb1c7f893655
http://europepmc.org/articles/PMC2933242
http://europepmc.org/articles/PMC2933242
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
PLoS ONE
PLoS ONE
Alzheimer's disease (AD) is the main cause of dementia in our increasingly aging population. The debilitating cognitive and behavioral symptoms characteristic of AD make it an extremely distressing illness for patients and carers. Although drugs have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6003ebab15a9de512a9502a0e4769cbd
http://europepmc.org/articles/PMC2946912?pdf=render
http://europepmc.org/articles/PMC2946912?pdf=render
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11466 (2010)
PLoS ONE
PLoS ONE
Several unique biological features of HIV-1 Vpr make it a potentially powerful agent for anti-cancer therapy. First, Vpr inhibits cell proliferation by induction of cell cycle G2 arrest. Second, it induces apoptosis through multiple mechanisms, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58257720b8a75a9bfc4df6cb2d1ee950
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20628645/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20628645/?tool=EBI
Autor:
Catherine L. Worth, Sandra Mueller, Jorge Enrique Hernández González, Ralf Paschke, Gunnar Kleinau, Gerd Krause, Holger Jaeschke
Publikováno v:
PLOS ONE, 5(3): e9745
PLoS ONE
PLoS ONE, Vol 5, Iss 3, p e9745 (2010)
PLoS ONE
PLoS ONE, Vol 5, Iss 3, p e9745 (2010)
In this study we wanted to gain insights into selectivity mechanisms between G-protein-coupled receptors (GPCR) and different subtypes of G-proteins. The thyrotropin receptor (TSHR) binds G-proteins promiscuously and activates both Gs (cAMP) and Gq (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ef93abf7f52f2d1110c230ad4013d7
https://repository.publisso.de/resource/frl:6402705
https://repository.publisso.de/resource/frl:6402705
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 3, p e9488 (2010)
PLoS ONE, Vol 5, Iss 3, p e9488 (2010)
The type of a nucleic acid and the type of the cell to be transfected generally affect the efficiency of electroporation, the versatile method of choice for gene regulation studies or for recombinant protein expression. We here present a combined squ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696e5f1db6930f8dbbbffb30bcb69633
https://pubmed.ncbi.nlm.nih.gov/20209146
https://pubmed.ncbi.nlm.nih.gov/20209146
Publikováno v:
PLoS ONE
PloS one, vol 5, iss 2
PLoS ONE, Vol 5, Iss 2, p e9114 (2010)
PloS one, vol 5, iss 2
PLoS ONE, Vol 5, Iss 2, p e9114 (2010)
Initiation factor eIF4G is a key regulator of eukaryotic protein synthesis, recognizing proteins bound at both ends of an mRNA to help recruit messages to the small (40S) ribosomal subunit. Notably, the genomes of a wide variety of eukaryotes encode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbab514deeff42745574948c5e7fb82
https://pubmed.ncbi.nlm.nih.gov/20161741
https://pubmed.ncbi.nlm.nih.gov/20161741