SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53

Autor: Blagosklonny, Mikhail V., Lynch, Cian J., Shah, Zahid H., Allison, Simon J., Ahmed, Shafiq U., Ford, Jack, Warnock, Lorna J., Li, Han, Serrano, Manuel, Milner, Jo

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 10, p e13502 (2010)

Background\ud The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4753eec1c74cb728a40f6f63e455d17d
http://europepmc.org/articles/PMC2958826

Environmental sex determination in the branchiopod crustacean Daphnia magna: deep conservation of a Doublesex gene in the sex-determining pathway

Autor: Yasuhiko Kato, Taisen Iguchi, Hajime Watanabe, Kaoru Kobayashi

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 7, Iss 3, p e1001345 (2011)

Sex-determining mechanisms are diverse among animal lineages and can be broadly divided into two major categories: genetic and environmental. In contrast to genetic sex determination (GSD), little is known about the molecular mechanisms underlying en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fcb210180b1118c583b11a026c19d0
https://pubmed.ncbi.nlm.nih.gov/21455482

Spliced leader trapping reveals widespread alternative splicing patterns in the highly dynamic transcriptome of Trypanosoma brucei

Autor: Laurent Farinelli, Loïc Baerlocher, Magne Osteras, Daniel Nilsson, Jan Mani, Isabel Roditi, Kapila Gunasekera, Torsten Ochsenreiter

Publikováno v: PLoS Pathogens, Vol 6, Iss 8, p e1001037 (2010)
Nilsson, Daniel; Gunasekera, Kapila; Mani, Jan; Osteras, Magne; Farinelli, Laurent; Baerlocher, Loic; Roditi, Isabel; Ochsenreiter, Torsten (2010). Spliced leader trapping reveals widespread alternative splicing patterns in the highly dynamic transcriptome of Trypanosoma brucei. PLoS pathogens, 6(8), e1001037. San Francisco, Calif.: Public Library of Science 10.1371/journal.ppat.1001037
PLoS Pathogens
PLoS pathogens

Trans-splicing of leader sequences onto the 5′ends of mRNAs is a widespread phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we have developed a method to simultaneously map 5′splice sites and analyze the correspond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31366bad5c7b96743ae01de94d8d07c
http://europepmc.org/articles/PMC2916883?pdf=render

UPF2 is a critical regulator of liver development, function and regeneration

Autor: Inge Damgaard, Bo T. Porse, Lina Thorén, Gitte A. Nørgaard, Anna M. Blom, Rehannah Borup, Frida C Bergstrom, Johannes Waage, Janus S. Jakobsen, Joachim Weischenfeldt, Hanne Cathrine Bisgaard

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11650 (2010)
PLoS ONE

BackgroundNonsense-mediated mRNA decay (NMD) is a post-transcriptional RNA surveillance process that facilitates the recognition and destruction of mRNAs bearing premature terminations codons (PTCs). Such PTC-containing (PTC+) mRNAs may arise from di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1020db4b1cc3918ac3edbfa5ad11766
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20657840/?tool=EBI

Transcriptomics: Throwing light on dark matter

Autor: Louisa, Flintoft

Publikováno v: PLoS Biology

Short-read RNA sequencing in mouse and human tissues shows that most transcripts are encoded within or nearby known genes and that most of the genome is not transcribed.
A series of reports over the last few years have indicated that a much larg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68dc55933982c6bb010f097192269ce9
https://pubmed.ncbi.nlm.nih.gov/20502517