Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Molecular Biology/Histone Modification"'
Publikováno v:
PLoS Biology
Chromatin organizer SATB1 and Wnt transducer β-catenin form a complex and regulate expression of GATA3 and TH2 cytokines in Wnt-dependent manner and orchestrate TH2 lineage commitment.
In vertebrates, the conserved Wnt signalling cascade promot
In vertebrates, the conserved Wnt signalling cascade promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3b62f0f2ce8508e6158ff34ff23a558
https://pubmed.ncbi.nlm.nih.gov/20126258
https://pubmed.ncbi.nlm.nih.gov/20126258
Autor:
Steven Henikoff, Jorja G. Henikoff, Carolyn A. Morrison, Parantu K. Shah, Robert A. H. White, X. Feng, Steven Russell, Christopher D. Brown, Lincoln Stein, Nicolas Nègre, Manolis Kellis, Kami Ahmad, Kevin P. White, Pouya Kheradpour
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 6, Iss 1, p e1000814 (2010)
PLoS Genetics, Vol 6, Iss 1, p e1000814 (2010)
Insulators are DNA sequences that control the interactions among genomic regulatory elements and act as chromatin boundaries. A thorough understanding of their location and function is necessary to address the complexities of metazoan gene regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c9c9831e6bbe247e04d37752bd0d17
Autor:
Gioacchino Natoli, Francesca De Santa, Flore Mietton, Chia-Lin Wei, Iros Barozzi, Betsabeh Khoramian Tusi, Sara Polletti, Heiko Muller, Serena Ghisletti, Jiannis Ragoussis
Publikováno v:
PLoS Biology, Vol 8, Iss 5, p e1000384 (2010)
PLoS Biology
PLoS Biology; Vol 8
PLoS Biology
PLoS Biology; Vol 8
A substantial fraction of extragenic Pol II transcription sites coincides with transcriptional enhancers, which may be relevant for functional annotation of mammalian genomes.
Mammalian genomes are pervasively transcribed outside mapped protein-
Mammalian genomes are pervasively transcribed outside mapped protein-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb5800846abc293902ba1199983024c
https://ora.ox.ac.uk/objects/uuid:35162c05-2208-4028-bf35-d685e2729d16
https://ora.ox.ac.uk/objects/uuid:35162c05-2208-4028-bf35-d685e2729d16
Autor:
Hsiu-Hsu Sophia Lin, Pierre Thibault, Eric Bonneil, Kyoko Hiragami-Hamada, Alain Verreault, Richard Festenstein, Axel Imhof, Harry Armstrong, Paul Drogaris, Benoit Guillemette
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 7, Iss 3, p e1001354 (2011)
PLoS Genetics, Vol 7, Iss 3, p e1001354 (2011)
Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification whose role in the regulation of gene expression has been extensively studied. In contrast, the function of H3K4 acetylation (H3K4ac) has received little attention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e65ae434fbc0eba4e4e081c079b7bc
http://europepmc.org/articles/PMC3069113
http://europepmc.org/articles/PMC3069113
Autor:
Viola Fabian, Peter B. Becker, Catherine Regnard, Tobias Straub, Angelika Mitterweger, Ina K. Dahlsveen
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1001327 (2011)
PLoS Genetics
PLoS Genetics
The ubiquitous tandem kinase JIL-1 is essential for Drosophila development. Its role in defining decondensed domains of larval polytene chromosomes is well established, but its involvement in transcription regulation has remained controversial. For a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec5ef0336d3f00b0d2844d0f4a46f91
http://europepmc.org/articles/PMC3053325?pdf=render
http://europepmc.org/articles/PMC3053325?pdf=render
Autor:
Geneviève Thon, Robert A. Martienssen, Jürg Bähler, Klavs R. Hansen, Janne Verhein-Hansen, Stephen Watt, Amikam Cohen, Idit Hazan, Janet F. Partridge, Sreenath Shanker
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001268 (2011)
Hansen, K R, Hazan, I, Shanker, S, Watt, S, Hansen, J V, Bähler, J, Martienssen, R A, Partridge, J F, Cohen, A & Thon, G 2011, ' H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases ', P L o S Genetics, vol. 7, no. 1 . https://doi.org/10.1371/journal.pgen.1001268
PLOS GENET, 7 (1), Article e1001268. (2011)
PLoS Genetics
Hansen, K R, Hazan, I, Shanker, S, Watt, S, Hansen, J V, Bähler, J, Martienssen, R A, Partridge, J F, Cohen, A & Thon, G 2011, ' H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases ', P L o S Genetics, vol. 7, no. 1 . https://doi.org/10.1371/journal.pgen.1001268
PLOS GENET, 7 (1), Article e1001268. (2011)
PLoS Genetics
Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me) and hypoacetylation have been evolutionarily conserved and are found in both m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a7cc59373e36097b4824b9756e9c44
http://europepmc.org/articles/PMC3017117?pdf=render
http://europepmc.org/articles/PMC3017117?pdf=render
Autor:
Brian A. Lenzmeier, Xiao-Hong Fu, Jin-Qiu Zhou, Wei Dang, Shanshan Wang, Bo O. Zhou, Yang Zhang
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001272 (2011)
PLoS Genetics
PLoS Genetics
Recent studies have established that the highly condensed and transcriptionally silent heterochromatic domains in budding yeast are virtually dynamic structures. The underlying mechanisms for heterochromatin dynamics, however, remain obscure. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fd6941f9b9cf13985892aab8f9d957
http://europepmc.org/articles/PMC3020936?pdf=render
http://europepmc.org/articles/PMC3020936?pdf=render
Autor:
Christine, Vogler, Claudia, Huber, Tanja, Waldmann, Ramona, Ettig, Lora, Braun, Annalisa, Izzo, Sylvain, Daujat, Isabelle, Chassignet, Andres Joaquin, Lopez-Contreras, Oscar, Fernandez-Capetillo, Miroslav, Dundr, Karsten, Rippe, Gernot, Längst, Robert, Schneider
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 6, Iss 12, p e1001234 (2010)
PLoS Genetics, Vol 6, Iss 12, p e1001234 (2010)
The tails of histone proteins are central players for all chromatin-mediated processes. Whereas the N-terminal histone tails have been studied extensively, little is known about the function of the H2A C-terminus. Here, we show that the H2A C-termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9007e0ab8b184d90209f19dd6b5e32f8
Autor:
Kees-Jan Francoijs, Arne H. Smits, Richárd Bártfai, Wieteke A. M. Hoeijmakers, Hendrik G. Stunnenberg, Adriana M. Salcedo-Amaya, Eva M. Janssen-Megens, Moritz Treeck, Anita Kaan, Tim-Wolf Gilberger
Publikováno v:
PLoS Pathogens
PLoS Pathogens; Vol 6
PLoS Pathogens, Vol 6, Iss 12, p e1001223 (2010)
PLoS Pathogens; Vol 6
PLoS Pathogens, Vol 6, Iss 12, p e1001223 (2010)
Epigenetic regulatory mechanisms and their enzymes are promising targets for malaria therapeutic intervention; however, the epigenetic component of gene expression in P. falciparum is poorly understood. Dynamic or stable association of epigenetic mar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cd5c42939c5ffe297acf6ebb6d0d76
http://europepmc.org/articles/PMC3002978
http://europepmc.org/articles/PMC3002978
Autor:
Domenico Parente, Vittorio Colantuoni, Lucia Altucci, Angela Nebbioso, Lina Sabatino, Vincenzo Carafa, Massimo Pancione, Nicola Normanno, Nicola Forte, Antonio Febbraro, Alessandra Fucci, Concetta Ambrosino
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 12, p e14229 (2010)
PLoS ONE, Vol 5, Iss 12, p e14229 (2010)
The relationship between peroxisome proliferator-activated receptor γ (PPARG) expression and epigenetic changes occurring in colorectal-cancer pathogenesis is largely unknown. We investigated whether PPARG is epigenetically regulated in colorectal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5a1deeea42a600655b6ae2f8e90981
http://europepmc.org/articles/PMC2997072
http://europepmc.org/articles/PMC2997072