CpG Islands: Starting Blocks for Replication and Transcription

Autor: Joana Sequeira-Mendes, Neil Brockdorff, Derek Huntley, Anwyn Apedaile, Ramon Diaz-Uriarte, María Gómez

Publikováno v: PLoS Genetics, Vol 5, Iss 4, p e1000446 (2009)
Biblos-e Archivo. Repositorio Institucional de la UAM
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PLoS Genetics

Genomic mapping of DNA replication origins (ORIs) in mammals provides a powerful means for understanding the regulatory complexity of our genome. Here we combine a genome-wide approach to identify preferential sites of DNA replication initiation at 0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df81c6e3c29e56f4fe510355b93cefbd
https://ora.ox.ac.uk/objects/uuid:eeed55a8-5a1a-4bf1-ac8d-2ec3cc6fc8af

The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress

Autor: Jeff Bachant, Ming-Ta Lee, Abla A. Bakir, Kristen N. Nguyen

Publikováno v: PLoS Genetics, Vol 7, Iss 3, p e1001355 (2011)
PLoS Genetics

SUMO conjugation is a key regulator of the cellular response to DNA replication stress, acting in part to control recombination at stalled DNA replication forks. Here we examine recombination-related phenotypes in yeast mutants defective for the SUMO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3de0802c82873d03554758417eea742
http://europepmc.org/articles/PMC3069114?pdf=render

A Signature Inferred from Drosophila Mitotic Genes Predicts Survival of Breast Cancer Patients

Autor: Maria Patrizia Somma, Ferdinando Di Cunto, Paolo Provero, C. Damasco, Maurizio Gatti, Antonio Lembo

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 2, p e14737 (2011)
PloS one 6 (2011): e14737. doi:10.1371/journal.pone.0014737
info:cnr-pdr/source/autori:Damasco C.; Lembo A.; Somma MP.; Gatti M.; Di Cunto F.; and Provero P./titolo:A signature inferred from Drosophila mitotic genes predicts survival of breast cancer patients/doi:10.1371%2Fjournal.pone.0014737/rivista:PloS one/anno:2011/pagina_da:e14737/pagina_a:/intervallo_pagine:e14737/volume:6

INTRODUCTION: The classification of breast cancer patients into risk groups provides a powerful tool for the identification of patients who will benefit from aggressive systemic therapy. The analysis of microarray data has generated several gene expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5143f99822406e315d5148774e5bfa39
http://europepmc.org/articles/PMC3046113

14-3-3 proteins regulate exonuclease 1-dependent processing of stalled replication forks

Autor: Kim Engels, Massimo Lopes, Marco Muzi-Falconi, Stefano Ferrari, Michele Giannattasio

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 7, Iss 4, p e1001367 (2011)

Replication fork integrity, which is essential for the maintenance of genome stability, is monitored by checkpoint-mediated phosphorylation events. 14-3-3 proteins are able to bind phosphorylated proteins and were shown to play an undefined role unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4dbe8160c5c0e83da9cb432d1b63272
https://doi.org/10.5167/uzh-49461

Mismatch Repair–Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ε

Autor: Igor B. Rogozin, Kirill V. Volkov, Erik Johansson, Jaroslaw Maceluch, Anna Y. Aksenova, Zachary F. Pursell, Youri I. Pavlov, Thomas A. Kunkel

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 6, Iss 11, p e1001209 (2010)

Yeast DNA polymerase ε (Pol ε) is a highly accurate and processive enzyme that participates in nuclear DNA replication of the leading strand template. In addition to a large subunit (Pol2) harboring the polymerase and proofreading exonuclease activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bd6c1cb373633694358ea968447ead
http://europepmc.org/articles/PMC2987839