Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Molecular Bases of Health & Disease"'
Publikováno v:
Biochemical Society Transactions
The BCL-2 protein family govern whether a cell dies or survives by controlling mitochondrial apoptosis. As dysregulation of mitochondrial apoptosis is a common feature of cancer cells, targeting protein–protein interactions within the BCL-2 protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebc3a99c1e09678ff9935b91c650c0e
https://doi.org/10.1042/bst20210753
https://doi.org/10.1042/bst20210753
Autor:
Patrick Lewis
Publikováno v:
Essays in Biochemistry
Cellular control of vesicle biology and trafficking is critical for cell viability, with disruption of these pathways within the cells of the central nervous system resulting in neurodegeneration and disease. The past two decades have provided import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8439e890397fade7ffeba91febd80e
https://doi.org/10.1042/ebc20210034
https://doi.org/10.1042/ebc20210034
Publikováno v:
Essays in Biochemistry
To date, mechanistic treatments targeting the initial cause of Parkinson's disease (PD) are limited due to the underlying biological cause(s) been unclear. Endosomes and their associated cellular homeostasis processes have emerged to have a significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a462cb7e4e7c66dd7778e4bbff42ab
https://doi.org/10.1042/ebc20210023
https://doi.org/10.1042/ebc20210023
Publikováno v:
Essays in Biochemistry
PTEN-induced kinase 1 (PINK1) impacts cell health and human pathology through diverse pathways. The strict processing of full-length PINK1 on the outer mitochondrial membrane populates a cytoplasmic pool of cleaved PINK1 (cPINK1) that is constitutive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c94d73c94e30d403438284e9f53a1f
https://doi.org/10.1042/ebc20210036
https://doi.org/10.1042/ebc20210036
Publikováno v:
Essays in Biochemistry
Parkinson's disease is a prominent and debilitating movement disorder characterized by the death of vulnerable neurons which share a set of structural and physiological properties. Over the recent years, increasing evidence indicates that Rab GTPases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ca671eeab9992b47650dcaee33388f
https://doi.org/10.1042/ebc20210016
https://doi.org/10.1042/ebc20210016
Publikováno v:
Essays in Biochemistry
COVID-19 symptoms and mortality are largely due to its devastating effects in the lungs. The disease is caused by the SARS (Severe Acute Respiratory Syndrome)-CoV-2 coronavirus, which requires host cell proteins such as ACE2 (angiotensin-converting e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0828f172605cdf0d11456b1b0acd76de
https://doi.org/10.1042/ebc20210005
https://doi.org/10.1042/ebc20210005
Publikováno v:
Clinical Science (London, England : 1979)
This review focuses on the most recent advances in the understanding of the electrolyte transport-related mechanisms important for the development of severe inherited renal disorders, autosomal dominant (AD) and recessive (AR) forms of polycystic kid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7b96f4ab345e1f5ec1120fa70518cf
http://europepmc.org/articles/PMC8589009
http://europepmc.org/articles/PMC8589009
Autor:
Shiyi Yin, Alekh Paranjapye, Monali NandyMazumdar, Shih Hsing Leir, James A. Browne, Ann Harris
Publikováno v:
Biochemical Journal
The cystic fibrosis transmembrane conductance regulator (CFTR) gene lies within a topologically associated domain (TAD) in which multiple cis-regulatory elements (CREs) and transcription factors (TFs) regulate its cell-specific expression. The CREs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fdb469750538054a451c59b02c9768
https://doi.org/10.1042/bcj20210252
https://doi.org/10.1042/bcj20210252
Publikováno v:
Biochemical Society Transactions
Altered protein ubiquitination is associated with the pathobiology of numerous diseases; however, its involvement in glycogen metabolism and associated polyglucosan body (PB) disease has not been investigated in depth. In PB disease, excessively long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d0d444d4a72ab54ff426a0cdcfcfca
http://europepmc.org/articles/PMC8589444
http://europepmc.org/articles/PMC8589444
Publikováno v:
Essays in Biochemistry
The non-coding genome, consisting of more than 98% of all genetic information in humans and once judged as ‘Junk DNA’, is increasingly moving into the spotlight in the field of human genetics. Non-coding regulatory elements (NCREs) are crucial to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055999c941c84755985cf2e59eaff1fc
https://doi.org/10.1042/ebc20200121
https://doi.org/10.1042/ebc20200121