Inhibition of BAK-mediated apoptosis by the BH3-only protein BNIP5.

Autor: Rühl S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.; T3 Pharmaceuticals, Allschwil, Switzerland., Li Z; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Srivastava S; Department of Biochemistry and Molecular Biology, UAMS College of Medicine, Little Rock, AR, 72205, USA., Mari L; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Guy CS; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang M; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Moldoveanu T; Department of Biochemistry and Molecular Biology, UAMS College of Medicine, Little Rock, AR, 72205, USA.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Green DR; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. douglas.green@stjude.org.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15.

Structural basis of BAK activation in mitochondrial apoptosis initiation.

Autor: Singh G; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.; Integrative Biomedical Sciences Program, University of Tennessee Health Sciences Center, Memphis, TN, 38163, USA., Guibao CD; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Seetharaman J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Aggarwal A; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Grace CR; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., McNamara DE; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Vaithiyalingam S; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Waddell MB; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Moldoveanu T; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. tudor.moldoveanu@stjude.org.; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA. tudor.moldoveanu@stjude.org.

Publikováno v: Nature communications [Nat Commun] 2022 Jan 11; Vol. 13 (1), pp. 250. Date of Electronic Publication: 2022 Jan 11.

Alzheimer's disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment.

Autor: Chen PC; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Han X; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Shaw TI; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL 33612, USA., Fu Y; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Sun H; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Niu M; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wang Z; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Jiao Y; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Teubner BJW; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Eddins D; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Beloate LN; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Department of Biomedical Engineering and Electrical Engineering, Penn State University, State College, PA 16801, USA., Bai B; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Department of Laboratory Medicine, Center for Precision Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China., Mertz J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: GlaxoSmithKline, Rockville, MD 20850, USA., Li Y; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Cho JH; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wang X; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA.; Present address: Department of Biology, University of North Dakota, Grand Forks, ND 58202, USA., Wu Z; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Liu D; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Poudel S; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Yuan ZF; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Mancieri A; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Low J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Lee HM; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Patton MH; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Earls LR; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Department of Biological Sciences, Loyola University of New Orleans, LA 70118, USA., Stewart E; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Vogel P; Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Hui Y; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wan S; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Bennett DA; Department of Neurological Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA., Serrano GE; Banner Sun Health Research Institute, Sun City, AZ 85351, USA., Beach TG; Banner Sun Health Research Institute, Sun City, AZ 85351, USA., Dyer MA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Smeyne RJ; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA., Moldoveanu T; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AK 72205, USA., Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wu G; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Zakharenko SS; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Yu G; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Present address: Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Peng J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Publikováno v: Nature aging [Nat Aging] 2022 Oct; Vol. 2 (10), pp. 923-940. Date of Electronic Publication: 2022 Oct 12.

Crystal Structures of Calpain–E64 and –Leupeptin Inhibitor Complexes Reveal Mobile Loops Gating the Active Site

Autor: Moldoveanu, T. ^†, Campbell, R.L., Cuerrier, D., Davies, P.L. ^*

Publikováno v: In Journal of Molecular Biology 2004 343(5):1313-1326

A killer metamorphosis: catching BAK in action at the membrane.

Autor: Ojoawo AM; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Moldoveanu T; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

Publikováno v: The EMBO journal [EMBO J] 2021 Oct 18; Vol. 40 (20), pp. e109529. Date of Electronic Publication: 2021 Sep 20.