Combined effect of CYP2C19 and CYP2D6 genotypes on escitalopram serum concentration and its metabolic ratio in a European patient population.

Autor: Faraj P; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway., Haslemo T; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Life Sciences and Health, Oslo Metropolitan University, Oslo, Norway., Tran JP; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway., Stingl J; Institute of Clinical Pharmacology, University Hospital of RWTH, Aachen, Germany., Molden E; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway., Hole K; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Life Sciences and Health, Oslo Metropolitan University, Oslo, Norway.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2024 Oct; Vol. 90 (10), pp. 2630-2637. Date of Electronic Publication: 2024 Jun 26.

Evidence for solanidine as a dietary CYP2D6 biomarker: Significant correlation with risperidone metabolism.

Autor: Wollmann BM; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway., Smith RL; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Kringen MK; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Life Science and Health, OsloMet - Oslo Metropolitan University, Oslo, Norway., Ingelman-Sundberg M; Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden., Molden E; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Pharmacy, University of Oslo, Oslo, Norway., Størset E; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2024 Mar; Vol. 90 (3), pp. 740-747. Date of Electronic Publication: 2023 Apr 11.

Impact of age, sex and cytochrome P450 genotype on quetiapine and N-desalkylquetiapine serum concentrations: A study based on real-world data from 8118 patients.

Autor: Solhaug V; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway., Tveito M; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway., Waade RB; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway., Høiseth G; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Molden E; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Pharmacy, University of Oslo, Oslo, Norway., Smith RL; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; NORMENT Center, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2023 Dec; Vol. 89 (12), pp. 3503-3511. Date of Electronic Publication: 2023 Jul 29.

How Real-World Data Can Facilitate the Development of Precision Medicine Treatment in Psychiatry.

Autor: Koch E; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: e.m.koch@medisin.uio.no., Pardiñas AF; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., O'Connell KS; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Selvaggi P; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy., Camacho Collados J; CardiffNLP, School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom., Babic A; Det Norske Veritas, Oslo, Norway., Marshall SE; Det Norske Veritas, Oslo, Norway., Van der Eycken E; Global Alliance of Mental Illness Advocacy Networks-Europe, Brussels, Belgium., Angulo C; Global Alliance of Mental Illness Advocacy Networks-Europe, Brussels, Belgium., Lu Y; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden., Sullivan PF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, North Carolina., Dale AM; Multimodal Imaging Laboratory, University of California San Diego, La Jolla, California; Departments of Radiology, Psychiatry, and Neurosciences, University of California, San Diego, La Jolla, California., Molden E; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway., Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., White N; CorTechs Laboratories, Inc., San Diego, California., Schubert A; European College of Neuropsychopharmacology, Utrecht, the Netherlands., Djurovic S; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; The Norwegian Centre for Mental Disorders Research Centre, Department of Clinical Science, University of Bergen, Bergen, Norway., Heimer H; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Nordic Society of Human Genetics and Precision Medicine, Copenhagen, Denmark., Stefánsson H; deCODE Genetics, Reykjavik, Iceland., Stefánsson K; deCODE Genetics, Reykjavik, Iceland., Werge T; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark; Lundbeck Foundation GeoGenetics Centre, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark., Sønderby I; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway., O'Donovan MC; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., Walters JTR; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia; Genetics and Personalized Medicine Clinic, Tartu University Hospital, Tartu, Estonia., Andreassen OA; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway. Electronic address: ole.andreassen@medisin.uio.no.

Publikováno v: Biological psychiatry [Biol Psychiatry] 2024 Oct 01; Vol. 96 (7), pp. 543-551. Date of Electronic Publication: 2024 Jan 05.

Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment.

Autor: Lenk HÇ; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway.; Centre for Precision Psychiatry, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Koch E; Centre for Precision Psychiatry, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., O'Connell KS; Centre for Precision Psychiatry, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Smith RL; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway., Akkouh IA; Centre for Precision Psychiatry, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Djurovic S; Centre for Precision Psychiatry, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway., Andreassen OA; Centre for Precision Psychiatry, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway., Molden E; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway. espen.molden@farmasi.uio.no.; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway. espen.molden@farmasi.uio.no.

Publikováno v: Human genomics [Hum Genomics] 2024 Sep 27; Vol. 18 (1), pp. 108. Date of Electronic Publication: 2024 Sep 27.