Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA.

Autor: Cho SI; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea; Department of Pharmacology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea., Lim K; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea., Hong S; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea; Department of Medicine, Korea University College of Medicine, Seoul 02708, Republic of Korea., Lee J; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea., Kim A; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea., Lim CJ; Edgene, Inc., Seoul 08790, Republic of Korea., Ryou S; Edgene, Inc., Seoul 08790, Republic of Korea., Lee JM; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea., Mok YG; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; GreenGene Inc., Seoul 08790, Republic of Korea., Chung E; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea., Kim S; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea; College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea., Han S; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea; Department of Biochemistry, College of Natural Sciences, Chungbuk National University, Cheongju 28644, Republic of Korea., Cho SM; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea., Kim J; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea; Department of Medicine, Korea University College of Medicine, Seoul 02708, Republic of Korea., Kim EK; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea., Nam KH; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea., Oh Y; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea., Choi M; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea., An TH; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Oh KJ; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Lee S; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Edgene, Inc., Seoul 08790, Republic of Korea; Department of MetaBioHealth, Sungkyunkwan University (SKKU), Suwon, Republic of Korea; Department of Precision Medicine, School of Medicine, Sungkyunkwan University (SKKU), Suwon, Republic of Korea. Electronic address: shlee9@skku.edu., Lee H; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea; Department of Medicine, Korea University College of Medicine, Seoul 02708, Republic of Korea. Electronic address: hjlee102@korea.ac.kr., Kim JS; Edgene, Inc., Seoul 08790, Republic of Korea; NUS Synthetic Biology for Clinical & Technological Innovation (SynCTI) and Department of Biochemistry, National University of Singapore, Singapore, Singapore. Electronic address: jskim01@snu.ac.kr.

Publikováno v: Cell [Cell] 2024 Jan 04; Vol. 187 (1), pp. 95-109.e26.

Targeted A-to-G base editing of chloroplast DNA in plants.

Autor: Mok YG; Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea.; GreenGene Inc., Seoul, Republic of Korea., Hong S; Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea.; GreenGene Inc., Seoul, Republic of Korea., Bae SJ; Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea., Cho SI; Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea.; Department of Chemistry, Seoul National University, Seoul, Republic of Korea., Kim JS; Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea. jskim01@snu.ac.kr.; GreenGene Inc., Seoul, Republic of Korea. jskim01@snu.ac.kr.

Publikováno v: Nature plants [Nat Plants] 2022 Dec; Vol. 8 (12), pp. 1378-1384. Date of Electronic Publication: 2022 Dec 01.

Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases.

Autor: Cho SI; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea., Lee S; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea., Mok YG; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea., Lim K; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea., Lee J; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea., Lee JM; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea., Chung E; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea., Kim JS; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea. Electronic address: jskim01@snu.ac.kr.

Publikováno v: Cell [Cell] 2022 May 12; Vol. 185 (10), pp. 1764-1776.e12. Date of Electronic Publication: 2022 Apr 25.

Application of 5-Methylcytosine DNA Glycosylase to the Quantitative Analysis of DNA Methylation.

Autor: Choi WL; Department of Agriculture, Forestry and Bioresources, Seoul National University, Seoul 08826, Korea., Mok YG; Interdisciplinary Program in Agricultural Genomics, Seoul National University, Seoul 08826, Korea., Huh JH; Department of Agriculture, Forestry and Bioresources, Seoul National University, Seoul 08826, Korea.; Interdisciplinary Program in Agricultural Genomics, Seoul National University, Seoul 08826, Korea.; Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.; Plant Genomics and Breeding Institute, Seoul National University, Seoul 08826, Korea.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 22; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 22.

Targeted C•G-to-T•A base editing with TALE-cytosine deaminases in plants.

Autor: Zhang, Dingbo¹ (AUTHOR), Pries, Vanessa¹ (AUTHOR), Boch, Jens¹ (AUTHOR) jens.boch@genetik.uni-hannover.de

Publikováno v: BMC Biology. 4/29/2024, Vol. 22 Issue 1, p1-12. 12p.