Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mojtaba Samoudi"'
Autor:
Helen O. Masson, Mojtaba Samoudi, Caressa M. Robinson, Chih-Chung Kuo, Linus Weiss, Km Shams Ud Doha, Alex Campos, Vijay Tejwani, Hussain Dahodwala, Patrice Menard, Bjorn G. Voldborg, Susan T. Sharfstein, Nathan E. Lewis
Publikováno v:
bioRxiv
Understanding protein secretion has considerable importance in the biotechnology industry and important implications in a broad range of normal and pathological conditions including development, immunology, and tissue function. While great progress h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53676e5d6c116dc02cf3c9d17fd3b921
https://doi.org/10.1101/2023.05.04.539316
https://doi.org/10.1101/2023.05.04.539316
Autor:
Km Shams-Ud-Doha, Sara Petersen Bjørn, Mojtaba Samoudi, Alexandre Rosa Campos, Caressa M Robinson, Stefan Kol, Chih-Chung Kuo, Nathan E. Lewis, Linus Weiss, Bjørn G. Voldborg, Song-Min Schinn
Publikováno v:
Biotechnology and bioengineering, vol 118, iss 2
Biotechnol Bioeng
Samoudi, M, Chung Kuo, C, Robinson, C M, Shams-Ud-Doha, K, Schinn, S-M, Kol, S, Weiss, L, Petersen Bjørn, S, Voldborg, B G, Rosa Campos, A & Lewis, N E 2021, ' In situ detection of protein interactions for recombinant therapeutic enzymes ', Biotechnology and Bioengineering, vol. 118, no. 2, pp. 890-904 . https://doi.org/10.1002/bit.27621
Biotechnol Bioeng
Samoudi, M, Chung Kuo, C, Robinson, C M, Shams-Ud-Doha, K, Schinn, S-M, Kol, S, Weiss, L, Petersen Bjørn, S, Voldborg, B G, Rosa Campos, A & Lewis, N E 2021, ' In situ detection of protein interactions for recombinant therapeutic enzymes ', Biotechnology and Bioengineering, vol. 118, no. 2, pp. 890-904 . https://doi.org/10.1002/bit.27621
Despite their therapeutic potential, many protein drugs remain inaccessible to patients since they are difficult to secrete. Each recombinant protein has unique physicochemical properties and requires different machinery for proper folding, assembly,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8f0540ae6dd0a70f166b8a5419f2d2
https://doi.org/10.1101/2020.05.06.081885
https://doi.org/10.1101/2020.05.06.081885
Autor:
Shangzhong Li, Oliver Rupp, Kelvin H. Lee, Shawn W. Polson, Madolyn L. MacDonald, Nicole Borth, Sven Griep, Haiping Hao, Kelley M. Heffner, Michael J. Betenbaugh, Mojtaba Samoudi, Nathan E. Lewis, Brewster F. Kingham, Inmaculada Hernandez, Vaibhav Jadhav, Alexander Goesmann, Heena Dhiman, Karina Brinkrolf
Publikováno v:
Biotechnology and bioengineering, vol 115, iss 8
Biotechnology and Bioengineering
Rupp, O; MacDonald, ML; Li, S; Dhiman, H; Polson, S; Griep, S; et al.(2018). A reference genome of the Chinese hamster based on a hybrid assembly strategy. BIOTECHNOLOGY AND BIOENGINEERING, 115(8), 2087-2100. doi: 10.1002/bit.26722. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/27b6z5c8
Biotechnology and Bioengineering
Rupp, O; MacDonald, ML; Li, S; Dhiman, H; Polson, S; Griep, S; et al.(2018). A reference genome of the Chinese hamster based on a hybrid assembly strategy. BIOTECHNOLOGY AND BIOENGINEERING, 115(8), 2087-2100. doi: 10.1002/bit.26722. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/27b6z5c8
Accurate and complete genome sequences are essential in biotechnology to facilitate genome‐based cell engineering efforts. The current genome assemblies for Cricetulus griseus, the Chinese hamster, are fragmented and replete with gap sequences and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e101b76d4a0f74814129b39776e9d91b
https://doi.org/10.1002/bit.26722
https://doi.org/10.1002/bit.26722
Publikováno v:
Current Opinion in Chemical Engineering. 32:100688
Mammalian cells have been used widely as biopharmaceutical cell factories due to their ability to make complex biotherapeutic proteins with human-compatible modifications. However, their application for some products has been hampered by low protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e3503578cb5efb12f9cf349eb8773c9
https://doi.org/10.1016/j.coche.2021.100688
https://doi.org/10.1016/j.coche.2021.100688
Autor:
Mojtaba Samoudi, Philipp Spahn, Chih-Chung Kuo, Nathan E. Lewis, Austin W. T. Chiang, Anne Richelle, Shangzhong Li
Publikováno v:
Chiang, A W T, Li, S, Spahn, P N, Richelle, A, Kuo, C-C, Samoudi, M & Lewis, N E 2016, ' Modulating carbohydrate–protein interactions through glycoengineering of monoclonal antibodies to impact cancer physiology ', Current Opinion in Structural Biology, vol. 40, pp. 104-111 . https://doi.org/10.1016/j.sbi.2016.08.008
Diverse glycans on proteins help impact cell and organism physiology along with drug activity. Since many protein-based biotherapeutics are glycosylated and these glycans have biological activity, there is a desire to engineer glycosylation for recom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457af0941be02bbe02b4b6233ae7cbe4
https://doi.org/10.1016/j.sbi.2016.08.008
https://doi.org/10.1016/j.sbi.2016.08.008
Autor:
Jae Seong Lee, Mojtaba Samoudi, Helene Faustrup Kildegaard, Gyun Min Lee, Tae Kwang Ha, Bernhard O. Palsson, Jin Hyoung Park, Nathan E. Lewis
Publikováno v:
ACS synthetic biology, vol 7, iss 12
Lee, J S, Park, J H, Kwang Ha, T, Samoudi, M, Lewis, N E, Palsson, B O, Kildegaard, H F & Min Lee, G 2018, ' Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing ', A C S Synthetic Biology, vol. 7, no. 12, pp. 2867-2878 . https://doi.org/10.1021/acssynbio.8b00290
Lee, J S, Park, J H, Kwang Ha, T, Samoudi, M, Lewis, N E, Palsson, B O, Kildegaard, H F & Min Lee, G 2018, ' Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing ', A C S Synthetic Biology, vol. 7, no. 12, pp. 2867-2878 . https://doi.org/10.1021/acssynbio.8b00290
Generation of recombinant Chinese hamster ovary (rCHO) cell lines is critical for the production of therapeutic proteins. However, the high degree of phenotypic heterogeneity among generated clones, referred to as clonal variation, makes the rCHO cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349431bd58ba933d67d02cb46964dce0
https://europepmc.org/articles/PMC6535434/
https://europepmc.org/articles/PMC6535434/
Autor:
Isaac Shamie, Chih-Chung Kuo, Nathan E. Lewis, Mojtaba Samoudi, Austin W. T. Chiang, Jahir M. Gutierrez
Publikováno v:
Current opinion in biotechnology. 51
To meet the ever-growing demand for effective, safe, and affordable protein therapeutics, decades of intense efforts have aimed to maximize the quantity and quality of recombinant proteins produced in CHO cells. Bioprocessing innovations and cell eng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c0a3c9faa14bda8b0349caabeb390a
https://pubmed.ncbi.nlm.nih.gov/29223005
https://pubmed.ncbi.nlm.nih.gov/29223005
Autor:
Mahvash Khodabandeh, Zarrin Minuchehr, Fatemeh Tabandeh, Mojtaba Samoudi, N Omid Yeganeh, S W Harcum
Publikováno v:
Protein Engineering, Design & Selection.
Recombinant human interferon-β (rhIFN-β) used clinically has lower efficacy than expected due to protein instabilities such as aggregation. Increasing molecular stability, glycoengineering has been used to improve clinical efficacy for a number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b0579458caedfedc99ad39306d3655d
https://doi.org/10.1093/protein/gzw058
https://doi.org/10.1093/protein/gzw058
Autor:
Mojtaba, Samoudi, Negar, Omid Yeganeh, Hossein, Shahbani Zahiri, Parvin, Shariati, Reza, Hajhosseini
Publikováno v:
Avicenna Journal of Medical Biotechnology
Background: Coenzyme Q 10 (CoQ 10 ) is an isoprenoid component used widely in nutraceutical industries. Farnesyl diphosphate synthase (FPPS) is a responsible enzyme for biosynthesis of farnesyl diphosphate (FPP), a key precursor for CoQs production.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dfd23d12c68d8d4eea84c5e24969f037
https://pubmed.ncbi.nlm.nih.gov/26306151
https://pubmed.ncbi.nlm.nih.gov/26306151
Autor:
Mohammad Sabery Anvar, Mojtaba Samoudi, Mahvash Khodabandeh, Zarrin Minuchehr, Reza Ahangari Cohan, Davoud Nouri Inanlou, Fatemeh Tabandeh
Publikováno v:
Journal of molecular graphicsmodelling. 56
Glycoengineering has been successfully used to improve the physicochemical and pharmaceutical properties of therapeutics. One aspect of glycoengineering is to introduce new N-linked glycosylation consensus sequences (Asn, X, Thr/Ser) into desirable p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94935dcfbef36d5b5fc35ab131e84d17
https://pubmed.ncbi.nlm.nih.gov/25544388
https://pubmed.ncbi.nlm.nih.gov/25544388