Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mojtaba Abdul Roda"'
Autor:
Kuldeep Kumawat, Ruben J. Geerdink, Marije P. Hennus, Mojtaba Abdul Roda, Ingrid van Ark, Thea Leusink-Muis, Gert Folkerts, Anita van Oort-Jansen, Alexandra Mazharian, Steve P. Watson, Frank E. Coenjaerts, Louis Bont, Linde Meyaard
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Neutrophils are crucial to antimicrobial defense, but excessive neutrophilic inflammation induces immune pathology. The mechanisms by which neutrophils are regulated to prevent injury and preserve tissue homeostasis are not completely understood. We
Externí odkaz:
https://doaj.org/article/68d3e6aaec414ebcb1893ff0140bd63d
Autor:
Mojtaba Abdul Roda, Mariam Sadik, Amit Gaggar, Matthew T Hardison, Michael J Jablonsky, Saskia Braber, James Edwin Blalock, Frank A Redegeld, Gert Folkerts, Patricia L Jackson
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97594 (2014)
A novel neutrophil chemoattractant derived from collagen, proline-glycine-proline (PGP), has been recently characterized in chronic obstructive pulmonary disease (COPD). This peptide is derived via the proteolytic activity of matrix metalloproteases
Externí odkaz:
https://doaj.org/article/fa13ee84223e4a499bcd177d2c785bbb
Autor:
Xin Xu, Patricia L Jackson, Scott Tanner, Matthew T Hardison, Mojtaba Abdul Roda, James Edwin Blalock, Amit Gaggar
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15781 (2011)
Chronic neutrophilic inflammation is a poorly understood feature in a variety of diseases with notable worldwide morbidity and mortality. We have recently characterized N-acetyl Pro-Gly-Pro (Ac-PGP) as an important neutrophil (PMN) chemoattractant in
Externí odkaz:
https://doaj.org/article/21259b6e4c3c450bbe5dfc2c0918bc93
Autor:
Xin Xu, Gert Folkerts, Liliana Viera, Mariam Sadik, George M. Solomon, Preston E. Bratcher, Tomasz Szul, J. Edwin Blalock, Amit Gaggar, J. Michael Wells, Mojtaba Abdul Roda, Tarek Abdalla, Carmel M. McNicholas, Frank A. Redegeld
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 61:560-566
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide and is characterized by an excessive airway neutrophilic response. The neutrophil chemoattractant proline-glycine-proline (PGP) and its more potent acetylated form (
Autor:
Morgan L. Locy, Qiang Ding, Patricia L. Jackson, Philip J. O'Reilly, Robert J. Snelgrove, Clare M. Lloyd, Kristopher R. Genschmer, Mojtaba Abdul Roda, Samia Akthar, Dhiren F. Patel, Liliana Viera, Guo-Qiang Cai, J. Edwin Blalock, Ellen A. Bernstein, Kenneth E. Bernstein
Publikováno v:
JCI Insight
The neutrophil chemoattractant proline-glycine-proline (PGP) is generated from collagen by matrix metalloproteinase-8/9 (MMP-8/9) and prolyl endopeptidase (PE), and it is concomitantly degraded by extracellular leukotriene A4 hydrolase (LTA4H) to lim
Autor:
Amit Gaggar, Preston Batcher, Frank A. Redegeld, Patricia L. Jackson, Tarek Abdalla, Xin Xu, Edwin Blalock, Tomasz Szul, Carmel M. McNicholas, Michael Wells, Gert Folkerts, Mojtaba Abdul Roda, George M. Solomon, Liliana Viera, Mariam Sadik, Daniel I. Sullivan
Publikováno v:
3.2 Airway Cell Biology and Immunopathology.
COPD is a major cause of mortality worldwide, mainly caused by cigarette smoking and driven by an excessive neutrophilic response. The matrikine ac-pro-gly-pro (acPGP) is derived from collagen and is chemotactic to neutrophils by acting on CXC recept
Autor:
Arne Lucas, Ten Hoeve, Mojtaba Abdul, Roda, Frank, Redegeld, Gert, Folkerts, James Edwin, Blalock, Amit, Gaggar
Publikováno v:
Tanaffos
The present review discusses the role of tri-peptide Proline –Glycine –Proline (PGP) as a potential player, biomarker and therapeutic target in this process.
Autor:
J. Michael Wells, Guy H. Handley, Philip J. O'Reilly, Mojtaba Abdul Roda, Daniel I. Sullivan, Bruce E. Miller, Tomasz Szul, Patricia L. Jackson, Stephen I. Rennard, Chris Garrett, J. Edwin Blalock, Amit Gaggar, Carmel M. McNicholas, Ruth Tal-Singer
Rationale: Chronic neutrophilic inflammation is a hallmark in the pathogenesis of chronic obstructive pulmonary disease (COPD) and persists after cigarette smoking has stopped. Mechanisms involved in this ongoing inflammatory response have not been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d6f72dc43664ea8c9b06a7ac7f9883
https://europepmc.org/articles/PMC4226028/
https://europepmc.org/articles/PMC4226028/
Autor:
Pim J. Koelink, Simone C. Wolfkamp, Gert Folkerts, Aletta D. Kraneveld, John A. W. Kruijtzer, Johan Garssen, J. Edwin Blalock, Rolf W. Sparidans, Saskia A. Overbeek, Mary E. Morgan, Hein W. Verspaget, Caleb Jones, Mojtaba Abdul Roda, Anje A. te Velde, Paul A.J. Henricks, Patricia L. Jackson, Saskia Braber
Publikováno v:
Gut, 63(4), 578-587. BMJ Publishing Group
Gut
Gut
Objective Proline–glycine–proline (PGP) has been shown to have chemotactic effects on neutrophils via CXCR2 in several lung diseases. PGP is derived from collagen by the combined action of matrix metalloproteinase (MMP) 8 and/or MMP9 and prolyl e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f024ce253900f58a516dc8959da1c87d
https://pure.amc.nl/en/publications/collagen-degradation-and-neutrophilic-infiltration-a-vicious-circle-in-inflammatory-bowel-disease(7b779fb4-3dc2-4b3f-8eb2-f6949e28e722).html
https://pure.amc.nl/en/publications/collagen-degradation-and-neutrophilic-infiltration-a-vicious-circle-in-inflammatory-bowel-disease(7b779fb4-3dc2-4b3f-8eb2-f6949e28e722).html
Autor:
Patricia L. Jackson, Amit Gaggar, Gert Folkerts, J.E. Blalock, Mojtaba Abdul Roda, Matthew T. Hardison, Saskia Braber, Frank A. Redegeld
Publikováno v:
B37. NEW INSIGHTS INTO ASTHMA AND COPD TREATMENT.