Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Mojmír Suchý"'
Autor:
Nicholas D. Calvert, Alexia Kirby, Mojmír Suchý, Peter Pallister, Aidan A. Torrens, Dylan Burger, Gerd Melkus, Nicola Schieda, Adam J. Shuhendler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Chronic kidney disease (CKD) and acute kidney injury (AKI) are ongoing global health burdens. Glomerular filtration rate (GFR) is the gold standard measure of kidney function, with clinical estimates providing a global assessment of kidney h
Externí odkaz:
https://doaj.org/article/f5f7b6f5ee5c42b68d9a9e38d99b75b6
Publikováno v:
New Journal of Chemistry. 45:13185-13195
A new approach to the fluorescent labelling of glycoproteins was developed utilizing the aldehyde-reactive N-amino anthranilic acid (NA3) moiety linked to a dansyl fluorophore. The presented synthetic method is based on the conjugation of isatin as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a176788fc0bbf7176d7983e766f95cf
https://doi.org/10.1039/d1nj02393d
https://doi.org/10.1039/d1nj02393d
Autor:
Nicholas David Calvert, Christina L. Addison, Emilie Marie Sophie Patit-Tha Brun, Alexia M. Kirby, Mojmír Suchý, Adam J. Shuhendler, Ruslan Garipov, Gerd Melkus
Publikováno v:
Chemical Communications. 57:10867-10870
A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5'-phosphate, a key Vitamin B6 metabolite necessary for >140 biotransformations was mapped by CEST-MRI in vitro and in vivo in lung cancer. 2-HYNIC p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ef344b4909acc623132fda06b00c26d
https://doi.org/10.1039/d1cc03704h
https://doi.org/10.1039/d1cc03704h
Autor:
Emilie Marie Sophie Patit-Tha, Brun, Nicholas David, Calvert, Mojmír, Suchý, Alexia, Kirby, Gerd, Melkus, Ruslan, Garipov, Christina L, Addison, Adam J, Shuhendler
Publikováno v:
Chemical communications (Cambridge, England). 57(83)
A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5'-phosphate, a key Vitamin B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7db0fa668bc0007e56fd9a23ea12b95b
https://pubmed.ncbi.nlm.nih.gov/34665184
https://pubmed.ncbi.nlm.nih.gov/34665184
Methyl 5-MeO-N-aminoanthranilate, a minimalist fluorogenic probe for sensing cellular aldehydic load
Publikováno v:
Organic & Biomolecular Chemistry. 17:1843-1853
Methyl 5-MeO-N-aminoanthranilate, a fluorogenic probe comprising a single substituted benzene ring has been applied towards the fluorescence detection of endogenous carbonyls through rapid, catalyst-free complexation of these bio-derived markers of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad1a81faeec568428c1d2c8afd70688
https://doi.org/10.1039/c8ob02255k
https://doi.org/10.1039/c8ob02255k
Publikováno v:
Chemical Communications. 55:5371-5374
A new radiotracer, [18F]NA3BF3, capable of rapid, stable, and catalyst-free complexation of aldehydes in vivo is reported. [18F]NA3BF3 was shown to bind aldehydes in live subjects using locally administered aldehyde-presenting microparticles, and was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99c03e7e32e3fa9d7fce78cf70e1b0cd
https://doi.org/10.1039/c9cc01831j
https://doi.org/10.1039/c9cc01831j
Publikováno v:
Carbohydrate research. 507
A concise, easily scalable synthesis of a rare ketohexose, d-tagatose, was developed, that is compatible with the preparation of d-[UL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cbbd6ab9808677a1d0708bc00b5c518f
https://pubmed.ncbi.nlm.nih.gov/34303197
https://pubmed.ncbi.nlm.nih.gov/34303197
Autor:
Ivana Radonjic, Anne-Gaëlle Rolland-Lagan, Adam J. Shuhendler, George Liu, Mojmír Suchý, Caitlin Lazurko
Publikováno v:
ChemBioChem. 20:543-554
Biogenic carbonyls, especially aldehydes, have previously demonstrated their potential to serve as early diagnostic biomarkers for disease and injury that have not been fully realized owing, in part, to the lack of a rapid and simple point-of-care me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfb40d6a1b94245dc94c7bef98942a8
https://doi.org/10.1002/cbic.201800427
https://doi.org/10.1002/cbic.201800427
Publikováno v:
Carbohydrate Research. 507:108377
A concise, easily scalable synthesis of a rare ketohexose, d -tagatose, was developed, that is compatible with the preparation of d -[UL-13C6]tagatose. Epimerization of the widely available and inexpensive ketohexose d -fructose at the C-4 position v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4b6048644ed20b6a203326e58404860
https://doi.org/10.1016/j.carres.2021.108377
https://doi.org/10.1016/j.carres.2021.108377
Publikováno v:
Chemical communications (Cambridge, England). 55(37)
A new radiotracer, [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88aa22d4ab933b769a19653bde123164
https://pubmed.ncbi.nlm.nih.gov/30994648
https://pubmed.ncbi.nlm.nih.gov/30994648