Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Mojie Duan"'
Publikováno v:
JACS Au, Vol 4, Iss 4, Pp 1422-1435 (2024)
Externí odkaz:
https://doaj.org/article/52346392d89e4cea926e983c1e2f4b9b
Autor:
Haiyi Chen, Yuxin Zhou, Xinyue Wang, Xin Chai, Zhe Wang, Ercheng Wang, Lei Xu, Tingjun Hou, Dan Li, Mojie Duan
Publikováno v:
Advanced Science, Vol 11, Iss 19, Pp n/a-n/a (2024)
Abstract Androgen receptor (AR) antagonists are widely used for the treatment of prostate cancer (PCa), but their therapeutic efficacy is usually compromised by the rapid emergence of drug resistance. However, the lack of the detailed interaction bet
Externí odkaz:
https://doaj.org/article/ee1187b4c35b4b3a982029d0762d8dd0
Autor:
Shangbo Ning, Hong-Jun Chao, Shuangli Li, Rui Zhou, Lei Zou, Xu Zhang, Jun Liu, Dazhong Yan, Mojie Duan
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1132-1141 (2022)
As the most abundant post-translation modifications (PTMs), the phosphorylation usually occurred on the intrinsically disordered regions (IDRs). The regulation on the structures and interactions of IDRs induced by phosphorylation is critical to the f
Externí odkaz:
https://doaj.org/article/8e795e764e2b4dbbb3f42146b1b78267
Autor:
Xueping Hu, Jinping Pang, Jintu Zhang, Chao Shen, Xin Chai, Ercheng Wang, Haiyi Chen, Xuwen Wang, Mojie Duan, Weitao Fu, Lei Xu, Yu Kang, Dan Li, Hongguang Xia, Tingjun Hou
Publikováno v:
Advanced Science, Vol 9, Iss 3, Pp n/a-n/a (2022)
Abstract Binding of different ligands to glucocorticoid receptor (GR) may induce different conformational changes and even trigger completely opposite biological functions. To understand the allosteric communication within the GR ligand binding domai
Externí odkaz:
https://doaj.org/article/983e9ea946634a7692f9406784185741
Autor:
Wenfang Zhou, Mojie Duan, Weitao Fu, Jinping Pang, Qin Tang, Huiyong Sun, Lei Xu, Shan Chang, Dan Li, Tingjun Hou
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 16, Iss 6, Pp 416-427 (2018)
Androgen receptor (AR) is a ligand-activated transcription factor that plays a pivotal role in the development and progression of many severe diseases such as prostate cancer, muscle atrophy, and osteoporosis. Binding of ligands to AR triggers the co
Externí odkaz:
https://doaj.org/article/aa671940c5c34c26b05f3e2792f75ec6
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The aggregation of human islet amyloid polypeptide (hIAPP) can damage the membrane of the β-cells in the pancreatic islets and induce type 2 diabetes (T2D). Growing evidences indicated that the major toxic species are small oligomers of IAP
Externí odkaz:
https://doaj.org/article/0183a43688614fc2b079b7a9966999ad
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3476 (2019)
As a member of the fatty acids transporter family, the heart fatty acid binding proteins (HFABPs) are responsible for many important biological activities. The binding mechanism of fatty acid with FABP is critical to the understanding of FABP functio
Externí odkaz:
https://doaj.org/article/da51f6a57cf94ae7a704f6b656a2b69f
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e47150 (2012)
The amyloid fibrils formed by islet amyloid polypeptide (IAPP) are associated with type II diabetes. One of the proposed mechanisms of the toxicity of IAPP is that it causes membrane damage. The fatal mutation of S20G human IAPP was reported to lead
Externí odkaz:
https://doaj.org/article/5ac377a6e8e540908c1d53927f326412
Autor:
Huan Tan1,2, Mojie Duan1 mjduan@wipm.ac.cn, Huayong Xie1, Yongxiang Zhao1, Hui Liu1, Minghui Yang1,3, Maili Liu1, Jun Yang1,3,4 yangjun@wipm.ac.cn
Publikováno v:
Science Advances. 5/10/2024, Vol. 10 Issue 19, p1-15. 15p.
Publikováno v:
Journal of Chemical Information and Modeling. 62:3651-3663
Protein kinases intrinsically translate their conformations between active and inactive states, which is key to their enzymatic activities. The conformational flipping of the three-residue conservative motif, Asp-Phe-Gly (DFG), is crucial for many ki