Understanding the Antiplasmodial Action of Resistance-Refractory Xanthoquinodin A1.

Autor: Collins JE; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States., Jiang T; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California 92093, United States., Lee JW; College of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea., Wendt K; Department of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States., Nardella F; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States., Jeon J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States., Paes R; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States., Santos NM; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States., Rocamora F; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California 92093, United States., Chang M; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California 92093, United States., Schaefer S; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California 92093, United States., Cichewicz RH; Department of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States., Winzeler EA; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California 92093, United States., Chakrabarti D; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2024 Jun 14; Vol. 10 (6), pp. 2276-2287. Date of Electronic Publication: 2024 May 29.

Antiplasmodial peptaibols act through membrane directed mechanisms.

Autor: Collins JE; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA., Lee JW; Department of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, Norman OK 73019, USA., Rocamora F; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Saggu GS; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA., Wendt KL; Department of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, Norman OK 73019, USA., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Smick S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Santos NM; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA., Paes R; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA., Jiang T; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Mittal N; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Luth MR; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Chin T; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Chang H; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., McLellan JL; Department of Molecular Microbiology and Immunology and South Texas Center for Emerging Infectious Diseases, University of Texas San Antonio, San Antonio, TX 78249, USA., Morales-Hernandez B; Department of Molecular Microbiology and Immunology and South Texas Center for Emerging Infectious Diseases, University of Texas San Antonio, San Antonio, TX 78249, USA., Hanson KK; Department of Molecular Microbiology and Immunology and South Texas Center for Emerging Infectious Diseases, University of Texas San Antonio, San Antonio, TX 78249, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Desai SA; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA., Winzeler EA; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: ewinzeler@health.ucsd.edu., Cichewicz RH; Department of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, Norman OK 73019, USA. Electronic address: rhcichewicz@ou.edu., Chakrabarti D; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA. Electronic address: dchak@ucf.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Feb 15; Vol. 31 (2), pp. 312-325.e9. Date of Electronic Publication: 2023 Nov 22.