Uterine miR-877-3p and let-7a-5p are increased during simulated menstruation in a mouse model

Autor: Marianne Watters, Catherine A Walker, Alison A Murray, Moira Nicol, Jacqueline A Maybin

Publikováno v: Reproduction and Fertility, Vol 3, Iss 1, Pp L3-L5 (2022)

Heavy periods are common and debilitating, but we do not fully understand how they are caused. Increased understanding of menstrual bleeding could result in new treatments for problematic periods. Low oxygen levels are present in the womb lining duri

Externí odkaz: https://doaj.org/article/b3f8f7f634754d3495e0403d475a94c2

Obesity is associated with heavy menstruation that may be due to delayed endometrial repair

Autor: Savita L. Brito-Mutunayagam, Sheona Sweeney, Hilary O. D. Critchley, Moira Nicol, Jacqueline A. Maybin, Alison A. Murray, Ana Cambursano, Catherine A. Walker, Jane J Reavey

Publikováno v: Reavey, J, Walker, C, Murray, A, Brito-Mutunayagam, S, Sweeney, S, Nicol, M, Cambursano, A, Critchley, H O D & Maybin, J 2021, ' Obesity is associated with heavy menstruation that may be due to delayed endometrial repair ', Journal of Endocrinology, vol. 249, no. 2, pp. 71-82 . https://doi.org/10.1530/JOE-20-0446
The Journal of Endocrinology

Heavy menstrual bleeding is common and debilitating but the causes remain ill defined. Rates of obesity in women are increasing and its impact on menstrual blood loss (MBL) is unknown. Therefore, we quantified BMI and MBL in women not taking hormones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a018c74c68035d3b0d800a9e6692f515
https://doi.org/10.1530/joe-20-0446

Promiscuous 3β–Hydroxysteroid Dehydrogenases: Testosterone 17β–Hydroxysteroid Dehydrogenase Activities of mouse Type I and VI 3β–Hydroxysteroid Dehydrogenases

Autor: A. F. Howie, Moira Nicol, B. E.C. Howe, Steven D. Morley, JI Mason, A. H. Payne

Publikováno v: Endocrine Research. 30:709-714

3Beta-hydroxysteroid dehydrogenase (3beta-HSD) activity is essential for the synthesis of all classes of steroid hormones, converting various delta5-3beta-hydroxysteroids into hormonally active delta4-3-ketosteroids in NAD+ -dependent reactions. Cert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aaa57e7cec5fb5f5a624cde5d729785
https://doi.org/10.1081/erc-200044008

Dopaminergic stimulation of cortisol secretion from bovine zfr cells occurs through nonspecific stimulation of adrenergic β-receptors

Autor: Simon W. Walker, Eric R. T. Lightly, Ian M. Bird, Moira Nicol, Brent C. Williams

Publikováno v: Endocrine Research. 24:769-772

Previous reports have suggested a possible dopaminergic inhibition of the actions of AII on aldosterone secretion via adenylate-cyclase inhibitory 'D2' receptors. Others suggest a possible stimulation of aldosterone secretion via a stimulatory 'D1' r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b0761c20fabbc22980146e33f237d9
https://doi.org/10.3109/07435809809032685

Estrogen biosynthesis in human H295 adrenocortical carcinoma cells

Autor: Sarah J. Johnson, Moira Nicol, Georgia Papacleovoulou, Richard Quinton, Trevor M. Penning, Mark W. J. Strachan, Andrew Advani, J. Ian Mason, Dean B. Evans

Publikováno v: Nicol, M R, Papacleovoulou, G, Evans, D B, Penning, T M, Strachan, M W J, Advani, A, Johnson, S J, Quinton, R & Mason, J I 2009, ' Estrogen biosynthesis in human H295 adrenocortical carcinoma cells ', Molecular and Cellular Endocrinology, vol. 300, no. 1-2, pp. 115-20 . https://doi.org/10.1016/j.mce.2008.10.032

Adrenocortical carcinoma is an uncommon malignancy and feminizing symptoms secondary to adrenal estrogen-secretion are extremely rare. The direct secretion of estradiol by adrenocortical tumors requires, in addition to the expression of aromatase (CY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b80ccd8fffd94f7edf931979d542a3
https://pubmed.ncbi.nlm.nih.gov/19026713