Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Moira M. Welch"'
Autor:
Jonathan Y. Hsu, Irene Scarfò, Martin J. Aryee, Moira M. Welch, Benjamin P. Kleinstiver, Jose Malagon-Lopez, Russell T. Walton, Kendell Clement, Y. Esther Tak, Marcela V. Maus, Alexander A. Sousa, Joy E. Horng, J. Keith Joung, Luca Pinello
Publikováno v:
Nature biotechnology
Broad use of CRISPR-Cas12a (formerly Cpf1) nucleases1 has been hindered by the requirement for an extended TTTV protospacer adjacent motif (PAM)2. To address this limitation, we engineered an enhanced Acidaminococcus sp. Cas12a variant (enAsCas12a) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b206a63656f9c96786b756d8eb274305
https://doi.org/10.1038/s41587-018-0011-0
https://doi.org/10.1038/s41587-018-0011-0
Autor:
Samuel H. Sternberg, Benjamin P. Kleinstiver, Ahmet Yildiz, J. Keith Joung, Jennifer A. Doudna, Janice S. Chen, Lucas B. Harrington, Yavuz S. Dagdas, Alexander A. Sousa, Moira M. Welch
Publikováno v:
Nature, vol 550, iss 7676
Nature
Nature
The RNA-guided CRISPR-Cas9 nuclease from Streptococcus pyogenes (SpCas9) has been widely repurposed for genome editing. High-fidelity (SpCas9-HF1) and enhanced specificity (eSpCas9(1.1)) variants exhibit substantially reduced off-target cleavage in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7591187f7d0e1cd6ee825c8ba6c2d5
https://doi.org/10.1038/nature24268
https://doi.org/10.1038/nature24268
Autor:
Martin J. Aryee, Luca Pinello, Russell T. Walton, Jose Malagon-Lopez, Kendell Clement, Marcela V. Maus, Y. Esther Tak, J. Keith Joung, Moira M. Welch, Jonathan Y. Hsu, Alexander A. Sousa, Benjamin P. Kleinstiver, Joy E. Horng, Irene Scarfò
Publikováno v:
Nature Biotechnology. 38:901-901
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::756491e981cac86605e410c7f634a744
https://doi.org/10.1038/s41587-020-0587-z
https://doi.org/10.1038/s41587-020-0587-z
Autor:
Yavuz S. Dagdas, Jennifer A. Doudna, J. Keith Joung, Benjamin P. Kleinstiver, Moira M. Welch, Ahmet Yildiz, Samuel H. Sternberg, Janice S. Chen, Lucas B. Harrington
The RNA-guided CRISPR-Cas9 nuclease from Streptococcus pyogenes (SpCas9) has been widely repurposed for genome editing1-4. High-fidelity (SpCas9-HF1) and enhanced specificity (eSpCas9(1.1)) variants exhibit substantially reduced off-target cleavage i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ce32ae662003fd7d0b44f688c09069
Autor:
Julian Taylor-Parker, Jeffrey D. Parvin, Al Ozonoff, Forest M. White, Ajit Bharti, Vibhu Sachdev, J. Keith Joung, Ravi Salgia, Koji Ando, Ankur K. Shah, Moira M. Welch, Yiheng Hu, Benjamin P. Kleinstiver, Lucia E. Rameh
Publikováno v:
Oncotarget
Impact Journals
Impact Journals
Proteasomal degradation of topoisomerase I (topoI) is one of the most remarkable cellular phenomena observed in response to camptothecin (CPT). Importantly, the rate of topoI degradation is linked to CPT resistance. Formation of the topoI-DNA-CPT cle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2107d094ce59c25b35f5ee105be6b6
https://pubmed.ncbi.nlm.nih.gov/28415827
https://pubmed.ncbi.nlm.nih.gov/28415827
Autor:
J. Keith Joung, Michelle S. Prew, Nhu T. Nguyen, Moira M. Welch, Jose Malagon Lopez, Martin J. Aryee, Zachary R. McCaw, Benjamin P. Kleinstiver, Shengdar Q. Tsai
CRISPR-Cas Cpf1 nucleases have recently been described as an alternative genome-editing platform, yet their activities and genome-wide specificities remain largely undefined. Here we show that two Cpf1 nucleases function robustly in human cells with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0377903297b2a5f255c07a6e1ff22b6b
https://doi.org/10.1101/057802
https://doi.org/10.1101/057802