Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Moira L. Bode"'
1
Akademický článek
Synthesis of phenanthridines via a novel photochemically-mediated cyclization and application to the synthesis of triphaeridine
Autor: Songeziwe Ntsimango, Kennedy J. Ngwira, Moira L. Bode, Charles B. de Koning
Publikováno v: Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 2340-2347 (2021)
Readily synthesized biphenyl-2-carbaldehyde O-acetyl oximes were exposed to UV radiation affording phenanthridines. The scope and limitations of this novel reaction were explored. For example, exposure of 2',3'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyd
Externí odkaz: https://doaj.org/article/a119e24540a846ba84887db34c070298
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2
Akademický článek
Total synthesis of ent-pavettamine
Autor: Memory Zimuwandeyi, Manuel A. Fernandes, Amanda L. Rousseau, Moira L. Bode
Publikováno v: Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1440-1446 (2021)
Pavettamine, a plant toxin first isolated from Pavetta harborii in 1995, was previously identified as a polyamine with C2 symmetry and a 1,3-syn-diol moiety on a C10 carbon backbone – one of very few substituted polyamines to be isolated from natur
Externí odkaz: https://doaj.org/article/7fb8ed3933424c8aae879895085a9ced
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3
Akademický článek
Studies towards the Design and Synthesis of Novel 1,5-Diaryl-1H-imidazole-4-carboxylic Acids and 1,5-Diaryl-1H-imidazole-4-carbohydrazides as Host LEDGF/p75 and HIV-1 Integrase Interaction Inhibitors
Autor: Thompho J. Rashamuse, Muhammad Q. Fish, E. Mabel Coyanis, Moira L. Bode
Publikováno v: Molecules, Vol 26, Iss 20, p 6203 (2021)
Two targeted sets of novel 1,5-diaryl-1H-imidazole-4-carboxylic acids 10 and carbohydrazides 11 were designed and synthesized from their corresponding ester intermediates 17, which were prepared via cycloaddition of ethyl isocyanoacetate 16 and diary
Externí odkaz: https://doaj.org/article/d939e3a7d7974ebab75efdfda9cdb7f4
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4
Akademický článek
Synthesis of 6-Membered-Ring Fused Thiazine-Dicarboxylates and Thiazole-Pyrimidines via One-Pot Three-Component Reactions
Autor: Reagan L. Mohlala, Elena Mabel Coyanis, Muhammad Q. Fish, Manuel A. Fernandes, Moira L. Bode
Publikováno v: Molecules, Vol 26, Iss 18, p 5493 (2021)
A facile and efficient one-pot three-component reaction method for the synthesis of thiazine-dicarboxylates is reported. Reaction of an isocyanide and dialkyl acetylenedicarboxylate with 2-amino-4H-1,3-thiazin-4-one derivatives containing both an aci
Externí odkaz: https://doaj.org/article/6c728d11a33b47dd98eafb9c6273b080
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5
Akademický článek
Substrate Profiling of the Cobalt Nitrile Hydratase from Rhodococcus rhodochrous ATCC BAA 870
Autor: Adelaide R. Mashweu, Varsha P. Chhiba-Govindjee, Moira L. Bode, Dean Brady
Publikováno v: Molecules, Vol 25, Iss 1, p 238 (2020)
The aromatic substrate profile of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870 was evaluated against a wide range of nitrile containing compounds (>60). To determine the substrate limits of this enzyme, compounds ranging in
Externí odkaz: https://doaj.org/article/fa2bf4b19f9b47aaa7f7664bb0a199dd
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6
Synthetic and Mechanistic Investigation of an Unexpected ­Intramolecular 1-5 Nitrogen to Carbon Tosyl Migration
Autor: Clinton G. L. Veale, Gciniwe S. Mathenjwa, Matthew P. Akerman, Moira L. Bode
Publikováno v: Synlett. 33:1907-1912
Controlled sulfonyl migration is considered an important transformation for total synthesis and scaffold elaboration. Accordingly, efforts to understand the underlying properties of these often serendipitously identified reactions have important impl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dae813f7f67279d221ec2c04242af57
https://doi.org/10.1055/a-1893-7550
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8
Catalyst-free synthesis of novel 1,5-benzodiazepines and 3,4-dihydroquinoxalines using isocyanide-based one-pot, three- and four-component reactions
Autor: Moira L. Bode, Reagan L. Mohlala, E. Mabel Coyanis, Manuel A. Fernandes
Publikováno v: RSC Advances. 11:24466-24473
Reaction of benzimidazolone derivatives, or their thio- or aza-counterparts, with an isocyanide in the presence of acetone unexpectedly gave rise to novel tricyclic benzodiazepine derivatives in good yield by means of a four-component reaction incorp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c52f1316edd1840aa33f48c6e5884b
https://doi.org/10.1039/d1ra04444c
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9
The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis
Autor: Roger A. Sheldon, Moira L. Bode, Dean Brady
Publikováno v: Chemical Science
Enzymes are excellent catalysts that are increasingly being used in industry and academia. This Perspective provides a general and practical guide to enzymes and their synthetic potential, primarily aimed at synthetic organic chemists.
Enzymes a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10142a5bc997612287dfa1d3e20e326e
http://europepmc.org/articles/PMC7069372
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10
Efficient one-pot synthesis of functionalised imidazo[1,2-a]pyridines and unexpected synthesis of novel tetracyclic derivatives by nucleophilic aromatic substitution
Autor: Charles R. K. Changunda, B. C. Venkatesh, William K. Mokone, Amanda L. Rousseau, Moira L. Bode, Dean Brady, Manuel A. Fernandes
Publikováno v: RSC Advances. 10:8104-8114
Novel tetracyclic imidazo[1,2-a]pyridine derivatives have been prepared by intramolecular nucleophilic aromatic substitution of 5-fluoroimidazo[1,2-a]pyridines under basic conditions. Use of the non-nucleophilic alcoholic solvent tert-butanol, rather
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd71fa3ca520e535c86dc6e8602d6597
https://doi.org/10.1039/c9ra10447j
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